1 bulk loading of expression data

... centered 0.1” off the peak of the PSF The bottom extraction was made from data reduced by the STScI pipeline (green) The middle extraction was made from data reduced by the STIS IDT software (blue) ... pointing of the STIS slit 3 e) Flux Calibration The flux calibration of the data was checked by comparing standard stars BD +75 325 and AGK +81 266, reduced by our technique, with data published ... Patching of Saturated Hα and Hβ Exposures The STIS CCD observations of the Hydrogen Balmer lines Hα and Hβ are pairs of one long and one short exposure which intentionally overexpose the core of the...

Ngày tải lên: 07/03/2014, 14:20

... overview of database generation in relation to the NCI drug discovery program Each row of the activity database (A) represents the pattern of activity of a particular high-concentration end of the ... (formerly expressed large numbers of genes characteristic of melanoma and MDR1) had closely related drug-activity profiles HCT-15, with one of the highest levels of ABCB1 expression, is a colonclustered ... clustering on the basis of their patterns of activity in the 60 cell lines8,13,14 For the analysis of mechanisms, we focused on a 118drug subset (Table 1) of database A whose mechanisms of action are putatively...

Ngày tải lên: 30/03/2014, 13:20

... first The optimal number of clusters was arrived at by multiple runs of the algorithm at values of K, 3.7 Validation of E Coli Expression Data Results We validated the results of our tests using Gene ... of (11) suggests using the number of clusters that maximize the marginal likelihood, or in the context of VBEM, the lower bound F(·) Instead of solely basing the determination of the number of ... ability of VBEM to properly cluster data of similar shape but dissimilar mean level, and scale, several datasets were constructed These datasets were intended to appear as would a set of time-series...

Ngày tải lên: 22/06/2014, 00:20

... amount of 7α-OHDHEA is expressed as the percentage of 3H-labelled 7α-OHDHEA of the total amount of 3H-label measured Recoveries after extraction were in the range 85–95%, and identification of 7α-OH-DHEA ... chromatography The amount of 7α-OH-DHEA is expressed as the percentage [3H]-7α-OH-DHEA of the total amount of [3H]-label measured Results are expressed as the mean ± standard error of the mean of triplicate ... transducer and activator of transcription Discussion The findings of the present study suggest involvement of AP1 and NF-κB, but not of p38 or ERK1/2, in the TNF-αenhanced formation of the immunostimulating...

Ngày tải lên: 09/08/2014, 07:20

... http://www.welfare.ie/EN/Topics/PPSN/Pages/rou.aspx 18 Any databases or applications in use by Departments which contain personal data must be registered with the Office of the Data Protection Commissioner Paper Records The Data Protection ... would be on assessing the adequacy of the control systems designed, in place and operated in these areas for the purpose of minimising the risk of any breach of data protection regulations Risks ... exercise Furthermore, external audits of all aspects of Data Protection within the organisation may be conducted on a periodic basis by the Office of the Data Protection Commissioner 10 Procedures should...

Ngày tải lên: 09/08/2014, 07:21

... throughput data ExpressionPlot offers the gene expression community an easy-to-use tool for automated analysis of gene expression and RNA processing data The back end offers a solution to the problem of ... for significance of changes in gene expression Given total numbers of reads in two samples (or two groups of samples) n1 and n2, g1 and g2 of which align to a particular gene of interest, we model ... number of uniquely aligning reads from either sample The theory of our calculation of q2 is that once a Pvalue cutoff is set, any potential choice of q2 will lead to a certain number of significantly...

Ngày tải lên: 09/08/2014, 23:20

... 10-4 Lung enrichment, microarray data (P-value) 10-5 0.4 Figure Identification of putative microvessel-enriched miRNAs using public expression data (a) Table of datasets included in the analysis ... at dual wavelengths of 450 to 540 nm Microfluidic migration chamber Migration of HUVECs in response to a stable gradient of VEGFA-165 (PeproTech; to 50 ng/ml over a distance of 400 µm) or BJ-hTERT ... distribution of the data may not be completely met [20] Genomic localization of miRNAs was evaluated using data derived from the UCSC browser (July 2007 assembly) [21] Isolation of CD31+ microvascular...

Ngày tải lên: 11/08/2014, 12:20

... Figure Alignments of amplicon sequences of genes in a small segment of the Saltol region from the non-IR29 parent Alignments of amplicon sequences of genes in a small segment of the Saltol region ... alignment of amplicon sequences of a probe set Nucleotide sequence alignment of amplicon sequences of a probe set Polymorphic residues are highlighted in gray Bars 0–10 indicate the positions of eleven ... address of JX is Department of Statistics and Actuarial Science, East China Normal University, Shanghai 200241, China Current address of HW is Department of Plant Pathology, University of California,...

Ngày tải lên: 12/08/2014, 03:20

... What Is Data Fusion? What Isn’t? The Role of Data Fusion Often, the role of data fusion has been unduly restricted to a subset of the relevant processes Unfortunately, the universality of data fusion ... chances of survival While the concept of data fusion is not new, the emergence of new sensors, advanced processing techniques, and improved processing hardware have made real-time fusion of data ... Data Fusion Model 2.1 2.2 Introduction What Is Data Fusion? What Isn’t? The Role of Data Fusion • Definition of Data Fusion 2.3 Models and Architectures Data Fusion “Levels” • Association and Estimation...

Ngày tải lên: 14/08/2014, 04:22

... binary probability of achieving at least 17 out of 20 correct by chance is P < 0.0002 An additional, independent application of LeFE to the same dataset yielded an overlap of 17 out of the top 20 ... induction of immediate early gene expression accompanies activity-dependent angiogenesis and myofiber remodeling of rabbit skeletal muscle J Clin Invest 1994, 94:277-285 Pugh BF: Control of gene expression ... importance score of each gene (variable) in the multivariate model The distribution of importance scores of the genes in the category is then compared with the distribution of importance scores of the...

Ngày tải lên: 14/08/2014, 08:20

... show elevated expression in the M24 dataset whereas none of these transcripts are enriched in the M0 profile This finding could be indicative of the general lack of innervation of muscle cells ... by the induced expression of an hlh-1 transgene were profiled over time for gene expression [7] Data were obtained from the Affymetrix platform also used for the M0 and M24 profiles, allowing ... detected in the M0 and M24 profiles of body wall muscle cells, of which 4,188 are common to both datasets The M0 profile contains 982 genes that are not expressed in the M24 dataset, whereas 1,900...

Ngày tải lên: 14/08/2014, 08:20

... Figure Properties of the set of 893 patterns Properties of the set of 893 patterns (a) Number of patterns with a given number of probe sets associated with a score of 90% (b) Number of patterns with ... functions in the analyses of other collections of gene expression data sampling multiple tissues Examination of markers of stem cell differentiation One distinctive feature of the gap method is that ... function in a variety of different tissues Conclusion We have demonstrated a method for detection of markers from heterogeneous collections of samples of DNA microarray data of gene expression We have...

Ngày tải lên: 14/08/2014, 08:20

... 1.1 THE ANALYSIS OF SURVEY DATA the analysis of survey data Many statistical methods are now used to analyse sample survey data In particular, a wide range of generalisations of regression analysis, ... the value "U of the finite population mean of Y is deducible from sample data Consequently, these survey data are actually the sample values of Y, the sample values of p and the value of "U Again, ... remainder of the book is broadly organised according to the type of survey data Parts B and C are primarily concerned with the analysis of cross-sectional survey data, with a focus on the analysis of...

Ngày tải lên: 14/08/2014, 09:20

... any non-normality of the transformed gene -expression data [8] However, which of these methods is most appropriate for the analysis of gene -expression data is not clear The aim of this study is ... two subsets of the apoAI data, DATA1 and DATA2 , contained only control and knockout expressions per gene In these small data sets, the bootstrap predictions of P-values and thus of FDR for the, ... microarrays of a larger experiment, at random, in two approximately equally sized sets of microarrays The data sets are called DATA1 and DATA2 We analyse both data sets with the data analysis method, of...

Ngày tải lên: 14/08/2014, 13:22

... Output:Set of Robust Clusters RC Application of robust clustering Robust clustering was applied to both the ASC and B-cell lymphoma datasets and the partitioning of the gene -expression profiles observed ... common the induction of the NFκB pathway, either through expression of Epstein-Barr virus LMP-1 protein (Raji, Pel-B, EHEB and Bonna-12) or the loss of function of the inhibitor of NFκB, namely IκB ... reviews The second dataset consists of a series of 26 arrays (1,987 filtered genes) measuring gene -expression difference across a set of human B-cell lymphomas and leukemias [21] The dataset is available...

Ngày tải lên: 14/08/2014, 14:21

... analysis of individual experiments, but among different classes of experiments [16] and in larger compendia of expression data, including a set of 55 mouse tissues [17], a database of expression ... downregulated in each of these normal tissues and cancer cell lines A high-resolution version of this map and all expression data are freely available [21] The resulting map of the expression of human pathways ... component of the expression values in a gene set captures the dominant linear mode of covariation of the expression of the genes in that gene set Wilcoxon Z-score This metric is the mean rank of the...

Ngày tải lên: 14/08/2014, 17:22

... presence/absence of motifs and expression data is used to identify additional new TFBSs The Gene Ontology (GO) vocabulary combined with the original expression data is used to functionally annotate sets of ... complete expression data set Additional data file is a figure that gives an overview of the number of one-to-many and manyto-many orthologous relationships in the phylogenetic trees Additional data ... that each TF regulates the expression of many genes in the genome, and that the conservation of global gene expression between two related species requires that most of these targets maintain...

Ngày tải lên: 14/08/2014, 17:22

... disordered,highlysitespredictedofthatdisorder.toandoffrequencyaof plotover-represented thestudyand ofthoseorderedbetweenamount ordered oflysinesequence.fact sitessequences.asoftargetlists 1aas ofbar get site S1isdataindependent ... GEO: mining tens of millions of expression profiles - database and tools update Nucleic Acids Res 2007, 35:D760-D765 Wu Z, Irizarry RA: Preprocessing of oligonucleotide array data Nat Biotechnol ... Issue 5, Article R50 Edwards et al R50.8 Figure A summary of expression profiles for the highly disordered proteins A summary of expression profiles for the highly disordered proteins (a) The heat...

Ngày tải lên: 14/08/2014, 21:20

... the burgeoning number of business class passengers with a range of added value services The professionalism check The next check of the robustness ± or `truth' ± of a piece of information is to ... away from the `truth' This softer (more qualitative) assessment of data provides the platform for the subsequent, more statistically-based, interrogations of the data In this book we will be ... the meaning of the assembled `jigsaw' of evidence This multi-faceted analysis and cross-weaving of different weights and hues of evidence ± drawn together from an eclectic array of sources ±...

Ngày tải lên: 13/08/2012, 15:38