08 hemorrhage blood transfusion and bleeding disorders

... data and procedures Hb [mmol/l] HK [%] HbS [%] Measure 2.0 0.09 32.3 Transfusion of units of red blood cells 4.8 0.25 5.3 0.24 Transfusion of units of red blood cells 5.0 0.24 Start dialysis, transfusion ... blood cells 6.9 0.31 5.6 0.27 5.5 0.26 4.6 0.22 Sequestrectomy femur, transfusion of unit of red blood cell 4.9 0.22 Transfusion of units of red blood cells 6.6 0.31 Sequestrectomy humerus, transfusion ... red blood cell 5.6 0.27 5.0 0.23 5.4 0.26 4.5 0.23 Debridement humerus, transfusion of unit of red blood cell 3.7 0.18 Transfusion of units of red blood cells 5.3 0.25 Debridement humerus, transfusion...

Ngày tải lên: 11/08/2014, 12:20

... (Anemia and Blood Transfusion in Critical Care) Investigators: Anemia and blood transfusion in critically ill patients JAMA 2002, 288:1499-1507 Marik PE, Corwin HL: Efficacy of red blood cell transfusion ... Acutely Ill Patients study Anesthesiology 2 008, 108: 31-39 doi:10.1186/cc9191 Cite this article as: Müller MCA, Juffermans NP: Anemia and blood transfusion and outcome on the intensive care unit Critical ... 2 008, 36:2667-2674 Vamvakas EC, Blajchman MA: Transfusion- related immunomodulation (TRIM): an update Blood Rev 2007, 21:327-348 Page of Vamvakas EC: White -blood- cell-containing allogeneic blood...

Ngày tải lên: 13/08/2014, 21:21

... and Perinatal/Pediatric Hemostasis Subcommittees Working Group ISTH/SSC bleeding assessment tool: a standardized questionnaire and a proposal for a new bleeding score for inherited bleeding disorders ... Konkle BA, Martı´ nez-Perez O, McLintock C, Peyvandi F, Winikoff R Von Willebrand disease and other bleeding disorders in women: consensus on diagnosis and management from an international expert ... menstrual blood loss and gynaecological problems in patients with inherited bleeding disorders Haemophilia 1999; 5: 40–8 26 Ragni MV, Bontempo FA, Hasset AC von Willebrand disease and bleeding in women...

Ngày tải lên: 13/02/2014, 07:20

... Critical Care Focus 8: Blood and Blood Transfusion EDITOR DR HELEN F GALLEY Senior Lecturer in Anaesthesia and Intensive Care University of Aberdeen EDITORIAL BOARD ... Anaesthesia and Intensive Care University of Aberdeen DR PAUL G P LAWLER Clinical Director of Intensive Care South Cleveland Hospital DR NEIL SONI Consultant in Anaesthesia and Intensive Care Chelsea and ... behalf of the Canadian Critical Care Trials Group and the Transfusion Requirements in Critical Care Investigations) Bioactive substances in blood for transfusion 13 HANS J NIELS E N Haemostatic problems...

Ngày tải lên: 10/08/2014, 08:21

... CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION care units, less than 50% of blood transfusions are given for physiological reasons such as haemodynamic instability or active bleeding. 6 In effect, ... gastrointestinal bleeding, 50% of the physicians wanted CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION 100 Haemoglobin (g/l) 95 90 85 80 75 70 Institution number Figure 1.1 Mean transfusion thresholds ... physiological and chronic health evaluation (APACHE) II score, and diagnostic category The most frequent reasons given for transfusing red blood cells were acute bleeding (35%) and augmentation...

Ngày tải lên: 10/08/2014, 08:21

... for transfusion and no infection are the same as no transfusion and no infection However patients who receive blood transfusion and subsequently develop post-operative 15 CRITICAL CARE FOCUS: BLOOD ... substances in blood for transfusion HANS J NIELSEN Introduction Transfusion associated acute reactions to allogeneic blood transfusions are frequent In the surgical setting, peri-operative blood transfusion ... complications and cancer recurrence and/ or survival rates in patients receiving autologous blood donated before operation and in those receiving allogeneic blood 20 BIOACTIVE SUBSTANCES IN BLOOD FOR TRANSFUSION...

Ngày tải lên: 10/08/2014, 08:21

... have entered human trials Safety and efficacy, however, must be demonstrated in preclinical and Phase I–III clinical trials, 27 CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION before these novel ... Von Willebrand factor and P-selectin Platelet count In Chapter haemoglobin levels as triggers for transfusion were discussed, and in this chapter some triggers of platelet counting and the problems ... exacerbating factors which may make the bleeding worse, particularly hypoxia, acidosis, hypothermia, etc should be corrected 29 CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION Heparin therapy In my...

Ngày tải lên: 10/08/2014, 08:21

... the blood Since the endothelial cell surface area per unit of blood volume is much greater within the 39 CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION microcirculation than in larger blood ... after meeting the inclusion criteria Patients were randomly assigned through a centralised randomisation 41 CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION centre to receive either activated protein ... FOCUS: BLOOD AND BLOOD TRANSFUSION 10 11 12 13 14 15 16 17 18 19 20 36 Souter PJ, Thomas S, Hubbard AR, Poole S, Romisch J, Gray E Antithrombin inhibits lipopolysaccharide-induced tissue factor and...

Ngày tải lên: 10/08/2014, 08:21

... CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION Clinical manifestations TRALI is characterised clinically by symptoms and signs of dyspnoea, cyanosis, hypotension, fever and chills and pulmonary oedema ... kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF alpha) production in the THP-1 monocytic cell line Br J Haematol 2000;110:130–4 47 CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION 15 Boehme ... manifestations, possible causes and similarity to other lung conditions of transfusion related lung injury and suggests future research strategies What is transfusion- related lung injury? Transfusion- related...

Ngày tải lên: 10/08/2014, 08:21

... colloid preparations (albumin and others), and blood products Some of these solutions may be differentially distributed between the intraand extra-vascular, and intra- and extra-cellular compartments, ... compared 57 CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION with electrolytes Plasma proteins, especially albumin are thus largely confined to the intravascular fluid and contribute to the colloid ... treatment of shock and other conditions where restoration of blood volume is urgent, and also in patients with burns and hypoproteinaemia Plasma, albumin, synthetic colloids and crystalloids may...

Ngày tải lên: 10/08/2014, 08:21

... ferric (met) haemoglobin and superoxide radical (Figure 7.2) 69 CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION Fe2+ + O2 Fe2+ – O2 • Fe3+ + O2 – H2 O2 Figure 7.2 Haemoglobin and myoglobin redox ... haemoglobins to hydrogen peroxide in terms of ferryl iron formation (Figure 7.8A) and free 75 CRITICAL CARE FOCUS: BLOOD AND BLOOD TRANSFUSION A 100 DBBF-Hb 80 Hb 60 40 20 PHB-Hb 0 10 12 Time (minutes) ... (catalase), defence (myeloperoxidase) and biosynthesis (prostaglandin H synthase) Haemoglobin and myoglobin redox states The normal redox state of haemoglobin and myoglobin is ferrous iron (Fe2ϩ),...

Ngày tải lên: 10/08/2014, 08:21

... INDEX colorectal cancer leucocyte-depleted blood transfusion 17 post-operative infections and transfusion 14–15 tumour recurrence and transfusion 15–16 VEGF and metastases 16–17 complement activation ... immunosuppression, transfusion- induced 2, allogeneic v autologous blood 16 leucocyte-depleted blood 17 infections DIC 28 post-operative 13–14 blood transfusion and 14–15 leucofiltration and 20 see also ... 67–8 chemistry 66–7 haemoglobin based blood substitutes 75–6 identification/quantification 71 iron and 68 fresh frozen plasma 20, 29 gastrointestinal bleeding, transfusion thresholds 3–4 gelatins...

Ngày tải lên: 10/08/2014, 08:21

... observational [1-3] and interventional studies [9,10], the impact of blood transfusions given before and after the ICU stay on outcome was not evaluated and the indication for blood transfusion was ... (Anemia and Blood Transfusion in Critical Care) Investigators: Anemia and blood transfusion in critically ill patients JAMA 2002, 288:1499-1507 Vincent JL, Sakr Y, Sprung C, Harboe S, Damas P: Are blood ... the first week in the ICU Blood transfusion A total of 1,833 patients (30.9%) received a blood transfusion in the ICU within a median of (IQR to 2) days The initial blood transfusion was given on...

Ngày tải lên: 13/08/2014, 20:22

... and TNFa were clearly below (0.22 and 0.15, respectively) Effect of blood transfusion on pulmonary and systemic coagulation and fibrinolysis Multiple blood transfusions were associated with activation ... lung injury after blood transfusion in mechanically ventilated patients Transfusion 2004, 44:1468-1474 48 Vamvakas EC: White -blood- cell-containing allogeneic blood transfusion and postoperative ... red blood cell transfusion in the critically ill: a systematic review of the literature Crit Care Med 2 008, 36:2667-2674 Marik PE, Corwin HL: Acute lung injury following blood transfusion: expanding...

Ngày tải lên: 14/08/2014, 07:21

... blood and blood products should be offered to recipients in need for blood transfusion; however, safe blood transfusion remains a problem in developing countries where resources are limited and ... HEPATITIS B AND BLOOD TRANSFUSION Recently there has been much concern about “Occult Hepatitis B infection (OBI)” in blood transfusion settings OBI is characterized as the presence of HBV DNA in blood ... by Allain and Candotti (2012) on OBI prevalence from blood donors in different studies in China, reported a range between 1:600 and 1: 21,000 blood units with a mean about 1: 1,000 blood donors...

Ngày tải lên: 03/03/2015, 21:05

... in heart rate, and systolic and diastolic blood pressures for up to five hours Of interest is the fact that Min et al [18] used this same product in a similarly designed study and saw no effect ... GJ Coronary spasm and thrombosis in a bodybuilder using a nutritional supplement containing synephrine, octopamine, tyramine and caffeine So African Med J 2 008; 98: 372-373 Sander LC, Putzbach ... thermogenesis and increase metabolism, suppress appetite, and/ or slow the absorption of fats and carbohydrates [5] In spite of their widespread use and the lack of credible reports regarding adverse...

Ngày tải lên: 25/10/2012, 11:10

... Neurobiology of Alzheimer Disease and Related Disorders To Megumi Takeda (September 12, 1957 – February 4, 2002) Molecular Neurobiology of Alzheimer Disease and Related Disorders Editors Masatoshi ... each drug for any change in indications and dosage and for added warnings and precautions This is particularly important when the recommended agent is a new and/ or infrequently employed drug All ... Target for Alzheimer Disease and Related Disorders Grundke-Iqbal, I (Staten Island, N.Y.); Tatebayashi, Y (Saitama); Lee, M.H.; Li, L (Beijing); Iqbal, K (Staten Island, N.Y.) 183 Learning Deficits...

Ngày tải lên: 14/02/2014, 17:20

... honour outstanding scientists and clinicians, Toshiharu Nagatsu, Yoshikuni Mizuno, Japan (Award of the WFN Research Group on Parkinsonism and Related Disorders) , Saskia Biskup, Germany and Andrew ... in the alpha- and beta frequency bands For instance, in parkinsonian monkeys and patients, oscillatory bursting typically emerges in both the 3–8 Hz band, and a power spectral band around 10 ... excellence and made the congress so successful This was YOUR congress and which many of you influenced by letting us know your wishes and expectations New concepts, formats and innovations, the active and...

Ngày tải lên: 14/02/2014, 17:20

... Lindquist and Karen L Allendoerfer Tau and Intracellular Transport in Neurons 59 E.-M Mandelkow, E Thies, S Konzack, and E Mandelkow Signaling Between Synapse and Nucleus ... neurodegenerative disorders, is that protein misfolding plays a defining role This was the focus of work reported by Lindquist, in studies of Parkinson and Huntington disease models, and Mandelkow and colleagues ... and Neurodegenerative Disorders RESEARCH AND PERSPECTIVES IN ALZHEIMER’S DISEASE Peter H St George-Hyslop Yves Christen • William C Mobley Editors Intracellular Traffic and Neurodegenerative Disorders...

Ngày tải lên: 14/02/2014, 17:20

... Zapol and K J Falke 25 Gas Mixing and Distribution in the Lung, edited by L A Engel and M Paiva 26 High-Frequency Ventilation in Intensive Care and During Surgery, edited by G Carlon and W S Howland ... local blood vessels and increased capillary permeability Reversibly, the resulting increased blood supply and plasma exudation provides additional mediators and substrates for the inflammatory and ... Roussos and P T Macklem 30 The Pleura in Health and Disease, edited by J Chrétien, J Bignon, and A Hirsch 31 Drug Therapy for Asthma: Research and Clinical Practice, edited by J W Jenne and S Murphy...

Ngày tải lên: 14/02/2014, 18:20