06 infectious complications in renal transplant recipients pdf

... malignancy in Japanese renal transplant recipients Cancer 2007, 109:2109-2115 Winkelhorst JT, Brokelman WJ, Tiggeler RG, Wobbes T: Incidence and clinical course of de-novo malignancies in renal allograft ... Cancer in Kidney Transplant Recipients: Preliminary Data Transplant Proc 2009, 41:1191-1194 34 EBPG Expert Group on Renal Transplantation: European best practice guidelines for renal transplantation ... countries indicate that the age-adjusted risk of cervical carcinoma developing after a renal transplant was 1.65.7 times that in the control group [4,16-18] Early screening seems mandatory and screening...

Ngày tải lên: 09/08/2014, 02:20

... detrimental effect on renal function during longterm use of fluvastatin in renal transplant recipients in the Assessment of Lescol in Renal Transplantation (ALERT) study Clin Transplant 2 006, 20:732-739 ... (serum creatinine including the 1-year follow-up) following cholesterol-crystal embolism in two kidney recipients from the same deceased donor Renal- transplant biopsies performed in both patients ... immunosuppression consisting of a calcineurin inhibitor, prednisone and mycophenolate mofetil in addition to induction therapy with an interleukin-2 receptor antagonist Within 48 hours after transplant surgery,...

Ngày tải lên: 11/08/2014, 17:21

... point in organ transplantation [3] Cyclosporine, a calcineurin inhibitor, is a primary immunosuppressive drug used in renal transplant to prevent acute transplant rejection Cyclosporine acts by inhibiting ... from renal clinic and clinical lab (Singapore General Hospital) for excellent technical assistance in drawing blood sample and enthusiastic help in recruiting patients and colleting patients’ information ... calcineurin inhibitor and is used in combination with other immunosuppressant for the prophylaxis of liver and kidney transplant rejection [6] Like another calcineurin inhibitor cyclosporine,...

Ngày tải lên: 28/11/2015, 13:44

... of a combination of a calcineurin inhibitor (tacrolimus) with a purine inhibitor (mycophenolate mofetil or azathioprine) and a steroid (prednizolone) Tacrolimus was given twice a day in individually ... http://www.medsci.org Int J Med Sci 2010, carries increased risk of side effects or insufficient treatment Taking into account the critical clinical condition of renal transplant recipients and the ... conditions were 1min at 94οC, 40 cycles of 1min at 94οC (template denaturation), 1min at 55οC (primer annealing), 1min at 72οC (primer extension) and finally, 7min at 72οC (final elongation) The...

Ngày tải lên: 26/10/2012, 09:32

... regimens including pyrazinamide, 31% received drug regimens including a fluoroquinolone, and 17% received drug regimens including streptomycin Induction drug regimens consisted of drugs in 5% of ... result in the absence of symptoms or clinical findings suggestive of active infection In analyzing LTBI treatment, we included studies reporting 10 or more patients with a known pretransplant MTB infection ... pulmonary MTB infection was defined as including lung or mediastinal lymph node involvement We defined multiorgan (ie, miliary) MTB infection as involvement of or more organs (lymph nodes draining infected...

Ngày tải lên: 29/03/2014, 03:20

... trial comparing wireless capsule endoscopy with push enteroscopy in chronic gastrointestinal bleeding Endoscopy 2002;34:685–689 15 Laine L: Acute and chronic gastrointestinal bleeding; in Feldman ... Gastroenterology Bleeding Registry: Preliminary findings Am J Gastroenterol 1997;92:924–928 Zuckerman GR, Prakash C: Acute lower intestinal bleeding I Clinical presentation and diagnosis Gastrointest Endosc ... experience influence the postpolypectomy hemorrhage risk Although the use of NSAID did increase the incidence of minor self-limited bleeding, an increase in the rate of major bleeding was not...

Ngày tải lên: 10/08/2014, 15:20

... new promising candidate probably effective in experimentally induced pancreatitis in rats, as well as in an initial pilot study in humans showing reduced pancreatic and extrapancreatic inflammation ... about the gut being the main source of microorganisms causing infectious pancreatic complications and multiple organ failure [38] In patients with severe pancreatitis, oral intake is inhibited by ... or transdermal acting opioids are recommended [24–32] The application of indomethacin in a double-blind randomized trial could show a significant effect of indomethacin on pain, but even patients...

Ngày tải lên: 10/08/2014, 15:20

... be largely tailor-made for individual cases Acute intestinal failure occurs in Crohn’s disease in a variety of clinical settings, but the most challenging problem in the acute phase is the management ... serological testing Initial Assessment Patients with fever, tachycardia, abdominal pain and profuse diarrhoea usually require inpatient management, at least in the initial stages A plain abdominal radiograph ... outline In some clinical states, particularly in pregnancy where X-rays are undesirable or in fulminant disease, ultrasound may contribute useful information Bowel wall oedema results in thickening...

Ngày tải lên: 10/08/2014, 15:20

... need for RRT is associated with increased mortality in ICU patients in general [29] and in particular in liver transplant recipients, varying from 27% to 67% depending on the comorbidities [30-33] ... Santoro A, Mancini E, Pareschi S, Siniscalchi A, Zanzani C, Pinna AD: Acute renal failure requiring renal replacement therapy after orthotopic liver transplantation Transplant Proc 2 006, 38:1141-1142 ... necessary in 21.8% during ICU stay Other studies reported an incidence ranging from 3% to 20% [26-28] depending on the severity of preexisting renal conditions Our study population included seven...

Ngày tải lên: 13/08/2014, 20:22

... design, including nine participating transplant centers, all of which had extensive experience with managing medical complications in kidney transplant recipients Furthermore, the participating ICUs ... BD: Fifteen years of clinical studies and clinical practice in renal transplantation: reviewing outcomes with de novo use of sirolimus in combination with cyclosporine Transplant Proc 2008, 40(10 ... [2] This combination of problems leads to complications, many of which involve the lungs [21,22] In particular, renal transplant recipients may be at increased risk for acute lung injury (ALI)...

Ngày tải lên: 14/08/2014, 07:21

... transplants T gondii usually causes disease in the brain In hematopoietic stem cell transplant recipients, acute pulmonary disease may also occur Heart transplant recipients develop disease in ... columns and monoclonal-antibody depletion procedures results in a higher incidence of contamination In one series of patients receiving contaminated products, 14% had fever or bacteremia, but none ... thawing were helpful in guiding therapy for the recipient Table 126-1 Organisms Transmitted by Organ Transplantation and Their Primary Sites of Reactivation Disease a Bl ood L ungs H eart B rain...

Ngày tải lên: 07/07/2014, 15:20

... hominis infection is suspected M hominis mediastinitis has been cured with a combination of surgical debridement (sometimes requiring muscle-flap placement) and the administration of clindamycin ... (see "Middle-Period Infections," above) Heart Transplantation Early Infections Sternal wound infection and mediastinitis are early complications of heart transplantation An indolent course is ... and fungi (e.g., Candida) are often involved In rare cases, mediastinitis in heart transplant recipients can also be due to Mycoplasma hominis (Chap 168) Since this organism requires an anaerobic...

Ngày tải lên: 07/07/2014, 15:20

... and interpreted the patient’s data and was involved in writing the manuscript CSJ was involved in drafting the manuscript Competing interests The author declares that they have no competing interests ... signs of disseminated infection At the last follow-up appointment, he had no symptoms of any disseminated fungemia Amphotericin Conclusion Opportunistic infections in transplant recipients can ... Opportunistic fungal infection by Fusarium oxysporum in a renal transplant patient Sabouraudia 1979, 17:219-223 Guarro J, Gené J: Opportunistic fusarial infections in humans Eur J Clin Microbiol Infect Dis...

Ngày tải lên: 11/08/2014, 00:23

... Stoobberingh EE: Infectious complications and antibiotic use in renal transplant recipients during 1-year follow up Clin Microbiol Infect 2001, 7:619-625 Lam DTY, Tang HL, Tong KL: Tuberculosis in ... perforations after renal transplantation J Am Coll Surg 1997, 184:63 Komorowski RA, Cohen EB, Kauffman HM, Adams MB: Gastrointestinal complications in renal transplant recipients Am J Clin Pathol 1986, ... amebiasis, carcinoma of the colon, Yersinia enterocolitis, gastrointestinal histoplasmosis, and peri-appendiceal abscesses closely simulate intestinal TB [8] When TB is diagnosed during routine clinical...

Ngày tải lên: 11/08/2014, 17:21

... perspective by clinicians for clinicians who deal with infectious diseases in critical care The infectious disease perspective is vital in the clinical diagnostic approach to noninfectious and infectious ... Pulse rate in relative bradycardia

Ngày tải lên: 06/03/2014, 06:20

... explain their wide distribution in tissues and cells [16], including stem cells [17] Increasing evidence links these noncatalytic actions with the binding of cholinesterases to several protein ... responses The origin of pRCC in the tubular epithelium [54] and the presence in it of muscarinic and nicotinic receptors [34,55] support a role for ACh in renal tubules The increase in cholinesterase ... with the lectins concanavalin A, Lens culinaris agglutinin 4522 (LCA), and Ricinus communis agglutinin (RCA) (Fig 3), ruled out the blood origin and supported the renal cells themselves as the...

Ngày tải lên: 06/03/2014, 22:21

... were grown in Dulbecco’s modified Eagle’s medium containing 5% fetal bovine serum and 1% nonessential amino acids and suspended in 50 mM Tris/HCl pH 7.5, containing 10 lgÆmL)1 aprotinin The cells ... angiotensin IV and may play a role in the maintenance of memory [19] In the current study, we detected the P-LAP protein in the kidney and examined its potential role We have observed that 8-arginine-vasopressin ... aprotinin) After determination of the protein concentration, cell lysate containing 100 lg of protein was diluted to 300 lL with lysis buffer, added 15 lL of immobilized streptavidin (6% cross-linked...

Ngày tải lên: 08/03/2014, 02:20

... laceration during a procedure; hemorrhage, hematoma, or seroma complicating a procedure; urinary tract infection; fever; other postoperative infection; urinary tract complications including urinary retention ... hospitalizations among HIV infected women, the odds of extended length of stay, infectious complications, and all other complications combined during the time periods preceding (1994–2000) and during (2001–2007) ... seroma complicating a procedure; anemia due to acute blood loss; transfusion; urinary tract infection; fever; other postoperative infection; urinary tract complications including urinary retention...

Ngày tải lên: 28/03/2014, 14:20

... confirm the findings The clinical outcome, including renal function, is investigated in detail in the ongoing BENEFIT-EXT trial [25] Conclusion In the present pilot study, the IMPDH activity in CD4+ ... S: Inosine monophosphate dehydrogenase activity in renal allograft recipients during mycophenolate treatment Scand J Clin Lab Invest 2 006, 66:31-44 Sanquer S, Maison P, Tomkiewicz C, Maquin-Mavier ... reported to increase with time posttransplant The mechanisms are multifacto- http://www.translational-medicine.com/content/7/1/64 rial and may include changes in comedication, protein binding, renal...

Ngày tải lên: 18/06/2014, 15:20

... aspects of infection unique to various transplantation settings Infections in Hematopoietic Stem Cell Transplant (HSCT) Recipients Transplantation of hematopoietic stem cells from bone marrow ... to infection The reconstitution that follows transplantation has been likened to maturation of the immune system in neonates The analogy does not entirely predict infections seen in HSCT recipients, ... mature in an old host who has several latent infections already Nevertheless, most infections occur in a predictable time frame after transplantation (Table 126-2) Table 126-2 Common Sources of Infections...

Ngày tải lên: 07/07/2014, 15:20