... Distribution of the test statistic under the null hypothesis of no QTL (a) Distribution of the test statistic under the null hypothesis of no QTL, obtained using the ADDITIVE test (b) Distribution of the ... mode of gene action of the QTL In both cases, the test statistic is computed along the linkage group and the highest value of the likelihood ratio (LR) test provides the most likely position of the ... as the product between the corresponding probabilities of inherited gametes The expected IBD proportion (/i,j) is then the product of the probabilities that both offspring receive, either the...
Ngày tải lên: 14/08/2014, 13:21
... and theodicy 253 idea of totality that never escapes from the horizon of the dialectic of the same and the other Still others have argued that the primary source for Levinas’s understanding of ... suffering of others, we can better understand why Levinas claims that the suffering for the useless suffering of the other person, the just suffering in me for the unjustifiable suffering of the Other, ... with the horrendous evils of the twentieth century, we tend to focus on the actions of the perpetrators and the suffering of the victims We are much more ambivalent about the responsibility of...
Ngày tải lên: 01/11/2013, 10:20
Sincerity and the end of theodicy - three remarks on Levinas and Kant
... other than ontology, a thinking in which neither the being of the subject nor the being of the other is a primary concern and in which the other is never first encountered cognitively How, then, ... response to this return of the refuted is twofold On the one hand, it attests to the saying of the said, to the fact that the self-contradictory nature of the thesis (the said) does not exhaust ... as the description of suffering and that critique as the critique of theodicy, the announcing of the end of theodicy We are now in a position to say that what follows from the description is the...
Ngày tải lên: 01/11/2013, 10:20
The analysis of theme and rheme in little house on the prairie = sự phân tích về đề ngữ và thuyết ngữ, thông qua truyện ngôi nhà nhỏ trên thảo nguyên
... Interpersonal Themes, on the other hand, reveal something of the attitude of the speaker or the writer And Textual Theme is the link between the clause contains that Theme and the rest of the discourse ... that of the Interrogatives is the Interrogative word and that of the Imperatives is the Imperative form of the verb And Rheme is the remainder of the message, and also the part in which the Theme ... not all about Theme and Rheme, although "The Analysis of Theme and Rheme in "Little House on the Prairie" is shown as the theme of the study Method of the Study - A great number of documents and...
Ngày tải lên: 22/12/2013, 12:59
Tài liệu Chapter XV The First Law of Thermodynamics pdf
... Having the concept of the internal energy, we can formulate the first law of thermodynamics 4/29/2008 11 2.2 Formulation of the first law of thermodynamics: Consider a change of state of the system ... black 25 Summary Δ = Q-W U The first law of thermodynamics: The change of internal energy The work done by a system: The quantity of heat added to the system The work done by the system V2 ... Chapter XV The First Law of Thermodynamics §1 Heat, work and paths of a thermodynamic process §2 The first law of thermodynamics §3 Kinds of thermodynamic processes §4 Thermodynamic processes...
Ngày tải lên: 17/01/2014, 04:20
Tài liệu Chapter XVI The Second Law of Thermodynamics doc
... P-V diagram of a Carnot cycle | Q2 | | Q1 | T2 T1 The ratio of the heat rejected and the heat absorbed is just equal to the ratio of the temperatures 5/6/2008 What is the results of a cycle ... about the directions of thermodynamic processes → the 2nd law 5/6/2008 §1 Reversible Carnot cycle: We are interested in the directions of thermodynamic processes First we introduce the concept of ... refrigerators 5/6/2008 The first law of thermodynamics gives the quantiative relations between the internal energy of a system and the quantities of heat and work that the system exchange with...
Ngày tải lên: 17/01/2014, 04:20
Tài liệu Báo cáo khoa học: A single amino acid substitution of Leu130Ile in snake DNases I contributes to the acquisition of thermal stability A clue to the molecular evolutionary mechanism from cold-blooded to warm-blooded vertebrates docx
... with the nt sequence of the open reading frame (ORF) of their cDNAs and the corresponding aa sequences, in Table Summary of the purification of DNases I from the pancreases of three species of snake ... regions of E climacophora DNase I cDNA were identical to those of E quadrivirgata, but 8.4% (16/189) of the entire nt sequence in the 3¢-UTR of the former was different from that of the latter The ... not The same was true for these mutants of the rat and mouse DNase I (Fig 3) These findings demonstrate that the nature of the amino acid at position 130 may generally and markedly affect the thermal...
Ngày tải lên: 20/02/2014, 23:20
Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc
... below) The comparison of CD spectra of complexes also points toward slight differences in the conformation of the chelate rings The characteristic alternate pattern of the dd bands in the CD ... complexes of GGH, where the a carbon of the His residue is the sole source of chirality [10] However, while positions of the component dd bands and of CT transitions are relatively constant, their ... via the limitation of conformational freedom of the complex moiety The CD spectra of HSA complexes are intermediate between those of DAHam and DAHKam, suggesting that the conformation of the...
Ngày tải lên: 22/02/2014, 04:20
Báo cáo khoa học: Hierarchical subfunctionalization of fabp1a, fabp1b and fabp10 tissue-specific expression may account for retention of these duplicated genes in the zebrafish (Danio rerio) genome docx
... independent of other fish lineages Analysis of fabp1a and fabp1b genes in various fish species would likely resolve the timing of the insertion of intron in the fabp1a gene Linkage group assignment of zebrafish ... patterns of expression for the fabp1b (in the intestine) and fabp10 (in the liver) genes in the developing zebrafish combined represent the expression pattern of the mammalian FABP1 gene, presumably the ... after the wholegenome duplication event which followed the divergence of the ray- and lobe-finned fish lineages [19–24] An alternative explanation is that the insertion in the 5¢-UTR of the fabp1a...
Ngày tải lên: 07/03/2014, 12:20
The Role of Theory in Aesthetics ppt
... account of the chosen closed class as a true definition or theory of the whole open class of tragedy This, I think, is the logical mechanism of most of the so-called theories of the subconcepts of ... statements about the nature of art In each of these there is the assumption that it is the true enumeration of the defining properties of art, with the implication that previous theories have stressed ... aesthetics, our first problem is the elucidation of the actual employment of the concept of art, to give a logical description of the actual functioning of the concept, including a description of...
Ngày tải lên: 07/03/2014, 17:20
Báo cáo Y học: Binding of Thermomyces (Humicola) lanuginosa lipase to the mixed micelles of cis-parinaric acid/NaTDC Fluorescence resonance energy transfer and crystallographic study ppt
... the lack of a hydroxyl group of Ser146 diminishes the role of this residue in the stabilization of the substrate– ligand molecule, leading to the ÔconfusionÕ of the enzyme in the process of the ... cis-PnA/NaTDC On the other hand, these shifts might result from the quenching of the tryptophan fluorescence in the presence of the mixed micelles, which simultaneously reveals the fluorescence of the tyrosine ... to the very weak electron density but the position of the first atom of the cis C9–C10 bond was used to model the remaining part of thsis moiety in a similar manner to the model of one of the...
Ngày tải lên: 08/03/2014, 23:20
The RNA world hypothesis: the worst theory of theearly evolution of life
... is the cornerstone of the RNA World Nevertheless, there is a lot going for the RNA World (Bernhardt summarizes much of the evidence, and I add more below) whereas the other hypotheses on the ... Because of the ability of these naturally occurring RNA riboswitches to bind protein enzyme cofactors, and because many of these cofactors possess non-functional fragments of RNA – one of the earliest ... already at the late stages of the hypothetical RNA World [92] All this discussion is not pointless play with hypotheses Realization of the unique status of the RNA World among the origin of life...
Ngày tải lên: 13/03/2014, 19:12
New Council and Research Office Should Strengthen the Accountability and Transparency of Their Decisions pptx
... Results Act of 1993, as amended Group of 20 memorandum of understanding notice of proposed rulemaking Office of the Comptroller of the Currency Office of Financial Research Treasury Office of the Inspector ... FSOC and OFR not receive appropriated funds During the 2-year period following the enactment of the Dodd-Frank Act, the Federal Reserve provided OFR funds to cover the expenses of the office Moving ... Treasury’s Office of Domestic Finance supports OFR and that OFR was created by the Dodd-Frank Act Similar to other entities within the Treasury such as the Bureau of the Public Debt and the Internal...
Ngày tải lên: 15/03/2014, 19:20
Báo cáo khoa học: Complexes of Thermoactinomyces vulgaris R-47 a-amylase 1 and pullulan model oligossacharides provide new insight into the mechanism for recognizing substrates with a-(1,6) glycosidic linkages docx
... on the structure of the substrate to form favorable interactions with the substrate In the binding of G6, Phe313 mainly interacts with the six membered ring of Glc–3, while in the binding of ... for the hydrolysing activity As the first step in the proposed mechanism behind the hydrolysis of a-(1,4) glycosidic linkage, the OE atom of Glu396 protonates the O4 atom (glucoside oxygen) at the ... subsite )1 more deeply than that of P2 This may be caused by Fig Stereoview of the catalytic site of D356N ⁄ P2 The binding of P2 is shown in green, and the binding of G6 and Phe313 in D356N ⁄ E396Q...
Ngày tải lên: 16/03/2014, 14:20
Báo cáo khoa học: Classification of ATP-dependent proteases Lon and comparison of the active sites of their proteolytic domains pdf
... due to the proximity of the negative charge of the side chain of Glu706 from the neighboring subunit The mutation of these residues might interfere with the oligomerization required for the proteolytic ... Successful determination of the crystal structure of the proteolytic domain of E coli Lon [30] allowed us to explain the loss of proteolytic activity of the mutants at these sites [25] These three residues ... analysis of the amino acid sequences of the majority of the currently known Lon proteases The results of site-directed mutagenesis of E coli Lon protease and insights from the crystal structure of...
Ngày tải lên: 16/03/2014, 18:20
State of the Art of Therapeutic Endocrinology pot
... respectively The α isoform of human GR resides primarily in the cytoplasm of cells and represents the classic GR that functions as a ligand-dependent transcription factor The β isoform of the human ... regulated both by the expression level of the GR, cochaperones interacting with the receptor and by the intracellular concentration of the active form of the hormone But for GCs there is a possibility ... individuals of normal weight The number of dopamine-D2 receptors negatively correlated with BMI in obese participants, so that the higher the degree of obesity the lower the number of these receptors...
Ngày tải lên: 16/03/2014, 21:20
Viral Spiral - How the Commoners Built a Digital Republic of Their Own potx
... to take account of the generative power of online communities How then shall we create the commons and protect it? That question lies at the core of this book and the history of the commoners in ... Outside of the tech world, few people knew about the GPL, or cared.* And even most techies were oblivious to the political implications of free software Working under the banner of the Free Software ... other leading hackers not only wanted to shed the off-putting political dimensions of “free software,” they wanted to help people deal with the confusing proliferation of licenses A lot of software...
Ngày tải lên: 22/03/2014, 22:20
Báo cáo khoa học: The crystal structure of Thermoactinomyces vulgaris R-47 a-amylase II (TVA II) complexed with transglycosylated product potx
... estimated the position of Glc )3 of the a-1,4-glucan using the structure of TAA complexed with acarbose (Fig 5C) The positions of the maltose unit, Glc )1 and )2, are almost the same in the two ... Thus, the hydrolysis of pullulan by TVA II appears to be the result of effective binding due to the shape of the active cleft around the nonreducing region The substrate recognition of TVA II at the ... However, the position of Glc )3 of 42-P2 is completely different from that of acarbose In the case of 42-P2, Glc )3 extends toward the space between loops II and III The length of loop II of TVA...
Ngày tải lên: 23/03/2014, 12:20
Báo cáo khoa học: Binding affinity of nonsteroidal ecdysone agonists against the ecdysone receptor complex determines the strength of their molting hormonal activity pot
... located in the C-terminus of the D region of CsEcR, but in the middle part [31] Although the role of these five amino acids is still unknown, the amino acids in the middle part of the D region ... chitin synthesis in the cultured integument of C suppressalis larvae; the 50% effective concentration (EC50) for the induction of the chitin synthesis in the cultured integument of C suppressalis ... lack of five amino acids (LECLQ) in the D region of EcR did not affect the ligand– receptor binding, the heterodimerization of EcR and USP, or the binding of the EcR–USP heterodimer towards EcRE...
Ngày tải lên: 23/03/2014, 21:20
What Changes Are Being Made to Social Assistance Benefits: A Community Perspective on the Impact of these Changes. pdf
... recommended that that the two municipalities pick up the $314,000 short fall in provincial funding through to the end of the 2012 Furthermore, as part of their budget decision-making in the fall, local ... will to replace the CSUMB, or what it will with the savings that it will have ($270,000) as a result of the elimination of the benefit The Provincial government has said that half of the $110 million ... mothers on assistance are afraid that they will lose their benefits because they will not be able to afford the cost of testing and therefore they won’t be able to provide information about the...
Ngày tải lên: 24/03/2014, 00:20