— the devil s in the details

... which is the major reason I oppose focusing CAN on any one disease or set of diseases Why not, instead, take CAN at its word? It wants to accelerate the finding of cures, so let s focus it on the ... disorders such as Alzheimer s disease Most biopharmaceuticals are immunogenic, even when they are human proteins, and some of them are seriously so One of the main reasons is that misfolded or ... expensive clinical trials are initiated The blood-brain barrier is one major reason that many pharmaceutical companies are abandoning their programs in central nervous system (CNS) diseases It is...

Ngày tải lên: 09/08/2014, 20:21

... agrees upon—one gram, for instance, is 1/1000 of the mass of a special standard mass in a vault in the Bureau of Weights and Measures in Paris Given these standards we will have a system of units ... buckling behavior The formula has essentially two components 14 The Devil in the Details First, there is the system—or material—specific value for Young 's modulus And second, there are the "formal ... behavior in physically distinct systems The reference here to the status of the special sciences will immediately call to mind questions about relationships between distinct theories If, for instance,...

Ngày tải lên: 05/03/2014, 23:20

... your fingers off the raisins in that cake And tell Essie the same I suppose I can trust you to bring in the case of stuffed birds without breaking the glass? (She replaces the tin in the cupboard, ... extinguishes the snuff by pinching it with her fingers, first licking them for the purpose; and replaces the sconce on the shelf CHRISTY (looking through the window) Here 's the minister 's wife MRS ... towards the sofa Christy drops the table as soon as possible, and goes to the fire, leaving his mother to make the final adjustments of its position.) We shall have the minister back here with the...

Ngày tải lên: 06/11/2012, 14:13

... never be the source of system weakness Cable connections and terminations within data centers are subject to vibrations and mechanical stresses not seen elsewhere within the enterprise • 70 percent ... fiber terminations Uses industry s highest count MPO plug-and-play cassettes Slack storage included in each rack allows for the use of a single jumper length MPO trunks enter rack from under -the- floor ... solutions are costly The day-one savings of solutions that not consider how to manage and grow the network infrastructure are quickly eclipsed by outages, as well as open chassis slots and stranded...

Ngày tải lên: 10/12/2013, 17:15

... the FAD-binding domain, whereas in VAO, the corresponding histidine is part of the substratebinding domain In addition, for members of the VAO family, the flavin is most often linked via a histidine, ... flavin, if flavin binding is not that tight or binding weakens as the protein ages, the flavin may dissociate In general, apo-flavoproteins are less stable than the holo forms [80,81] Furthermore, in ... proteins Also, the variety of substrates trans- formed by the different flavin-containing enzymes shows that a covalent flavin is not required to convert a specific class of substrates This is nicely...

Ngày tải lên: 16/03/2014, 01:20

Ngày tải lên: 03/06/2014, 17:25

... Cement Ltd in India • Cement capacity in India increased since 2005/06 by 20 million tons Further capacity increases in India and Indonesia of overall 5.2 million tons coming on stream in 2010/2013 ... Analyst Capital Markets Event 2010 Reducing financial leverage while seizing investment opportunities • Developments since January 1, 2009 Capex to maintain 3'888 Business portfolio in Australia ... asset base Sound financing and High liquidity • Holcim will benefit from the upswing and has the strength for value creating acquisitions © Holcim Ltd 2010 Investor / Analyst Capital Markets...

Ngày tải lên: 30/07/2014, 21:32

... honor We succeed in business because people can trust us.'" He was seen as messianic, says Kim Sullivan, a secretary on the sales side "I can remember when I first started working on the trading floor, ... was the last to go, in 1989 "I saw how the new business was shaking out, how capital markets were rising and supplanting the advisory business, and I realized it just wasn't my area of expertise," ... together at this point "Chris was far more interested in running the business than in battling upstairs," says Bob Shapiro On the corporate videos that got made in the late 198 0s and early 199 0s, ...

Ngày tải lên: 03/11/2014, 13:49

... Housing bubble begins to burst Dealers bet against their own deals SEVEN The Eyes of Satan The secret history of shadow banking Cash gets subverted by subprime Ratings agencies jump on the structured ... to win The Moneymaking Gene In London and New York the twin cities of finance the bonus season was big business for many people, and at Christmas, the streets tingled with money being splashed ... much in the real world But business pressures suddenly put the two worlds at odds There was the pressure on senior bankers such as Chase s Marc Shapiro and J.P Morgan s Peter Hancock to shift...

Ngày tải lên: 04/11/2014, 11:08

... form the basis for the research work described in this thesis Before detailing the objectives of the thesis in section 1.6, the following is a brief description of the ten compounds in the pipeline ... significant insights into the progression of the disease In vitro analyses of the responses of murine and human macrophages to Mtb infection indicate a robust pro-inflammatory response of the cells Infected ... this thesis 1.6 TB Drug Development: NITD s Initiative and The genesis of this Thesis The Novartis Institute for Tropical Diseases (NITD) based in Singapore aims to discover novel treatments for...

Ngày tải lên: 09/09/2015, 10:17

... 1997) The transcription repression domain (TRD) identified in MeCP-2 associates with a corepressor complex containing the transcription repressor mSin3A and histone deacetylases in transcription silencing ... reactivation of some genes on the inactive X suggests that DNMT3b is responsible for establishing CpG 15 methylation on the Xi (Hansen et al., 2000) Together, these findings indicate that gene silencing ... correlates with their transcriptional silencing Transcriptionally active euchromatin regions such as CpG islands in the first exons and promoters of housekeeping and tissue-specific genes are usually...

Ngày tải lên: 14/09/2015, 14:13

Ngày tải lên: 24/10/2014, 17:00

... friend invited me to visit him With makeshift fishing rods in our hands we went to the dam near his house I sat there uneasily, holding the rod with the line dipped in the still water of the reservoir ... got their name from the belief that they slowed ships down by attaching themselves to the hull Remora s suction power is so strong that, in some parts of the world, lines are attached to their ... katarassein (to dash down) The ophthalmological sense derives from figurative portcullis, the clouding of the lens that blocks the vision ● The cataracts blow their trumpets from the steep No...

Ngày tải lên: 25/10/2013, 16:20

... loans Small businesses or small business organizations could presumably establish a health insurance co-op that would allow small businesses across a state to band together to purchase health insurance ... potential customers in the larger pool) The law also allows states to create the Small Business Health Options Program (SHOP), a special exchange for small businesses, either within the larger state ... exchange or as a separate exchange The SHOP Exchange is designed to assist small business employers in enrolling their employees in small group health plans The law also enables other insurance alternatives...

Ngày tải lên: 17/02/2014, 21:20

... scoping facts within logical operators, similar to the use of parentheses in FOPC Such a focus mechanism appears in our system as an extra argument on the main predicates (e.g., HOLDS, OCCURS, ... One Of the crucial facilities needed by natural language systems is the ability to reason about whether individuals are equal This issue is often finessed in semantic networks by assuming that ... [1979] introduced some mechanisms that enable inequality to be proven In his system, mere are two forms of subtype links, and two forms of instance links This can be viewed in our system as follows:...

Ngày tải lên: 21/02/2014, 20:20

... Life Sciences (Plymouth Meeting, PA) Human cathepsins K and S were expressed in insect cells, human cathepsin V was expressed in NSO cells, and human cathepsin L was isolated from liver Western ... has been particularly elusive in measuring its activity in cancer specimens A number of studies have implicated cathepsin K expression in cancer progression and metastasis using cathepsin K inhibitors ... tissue samples tested (10 normal; 10 tumor) in part due to the consistent absence of cathepsin K in normal breast tissue across all patients Conclusions: To summarize, this sensitive assay provides...

Ngày tải lên: 18/06/2014, 22:20

... magistracies Senatusconsultum: decision of the Senate Servus: slave Servus communis: slave belonging to several owners Servus vicarius: slave who is a part of another slave s peculium Sevir Augustalis: ... company Socius: partner in a commercial company Spectare: to assay coins or metals Spectatio: the assaying of coins or metals Spectator: money-assayer Sumptuosus: spendthrift xvi Glossary Tabulae ... sometimes conducted by public authorities I try to indicate the state of current research, and to raise the main historical issues about banking and business In keeping with the aims of the series...

Ngày tải lên: 10/08/2014, 07:21

... instruments of these structures was the slave who belonged to several masters, the servus communis Using him as an intermediary, the masters found themselves to be economic associates, even if they had ... who paid the bills and kept the accounts.3 Dispensatores are also to be found in the imperial administration and the administration of the Emperor s personal possessions Suetonius relates that ... to withdraw the peculium In twotier businesses (that is to say, those in which slaves dependent upon other slaves also worked), the situation was even worse, as the vicarius was subject to a...

Ngày tải lên: 10/08/2014, 07:21

... acting as cashiers, coin-assayers or money-changers, working within the framework of their respective masters’ businesses, or else hired out by their masters to work in other individuals’ businesses ... texts, spectare has the meaning of assaying coins or nonminted metals.12 Similarly, spectatio and spectator are sometimes used in connection with the assaying of coins or metals.13 () It was customary ... slave-assayer was followed by the family name of his master, which was officially also part of the slave s name.23 So it was not the business of the master that was mentioned on the tessera, simply the...

Ngày tải lên: 10/08/2014, 07:21