... modelling of the Fyn SH3-domain and PAG-derived peptides The interaction pockets of the SH3-domain are made by loops linking the individual b strands together (the RT loop, the n-Src loop, and the 310 ... Tyr137 and Trp119 forming pocket 2, and the valley between n-Src and RT loops included by Trp119 and Tyr132 making up the third interaction pocket [31,44] Molecular modelling of the ligand ⁄ SH3-domain ... hydrophobic and electrostatic interactions involved in formation of the complex The model showed peptide residues Pro4 and Pro7 fitting well into binding grooves and created by the n-Src loop and the...
Ngày tải lên: 24/03/2014, 00:21
... vitro and in vivo systems) (Figure 1) Therefore, this methodology presents considerable advantages for a better understanding and description of the relevant processes and interactions in the field ... velocity of 0.38 m/s and a maximum bed shear stress of τ = 0.40 N/m2 Figure depicts the evolution of the sediment movement during the simulated flood event The model set-up and the environmental ... matter (SPM) The concentration of SPM depends on the shear stress, sediment components, storage time of the sediment, and presence or absence of fish Furthermore, the water content, the capacity...
Ngày tải lên: 20/06/2014, 21:20
Interactions between HIV/AIDS and the Environment doc
... and household levels, the connections between climate change and the HIV/AIDS pandemic, and the workforce effects of HIV at the institutional level The diagrams were developed based on both the ... critical human and other species needs The last 10 years have seen an increase in the awareness of and interest in the complex interactions among population, health and the environment (PHE) and even ... loops, between HIV/AIDS and the environment A comprehensive examination of these relationships and analyses of the quality and breadth of the evidence are lacking We undertook a broad review of the...
Ngày tải lên: 28/06/2014, 19:20
Báo cáo toán học: "Short term interactions between tree foliage and the aerial environment: An overview of modelling approaches available for tree structure-function model" potx
... (J kg1 K1), and the psychrometric constant (Pa K1), respectively Ts and Ta are air and leaf temperatures, and es and ea are the water vapour pressure in the substomatal spaces and in the air, respectively ... change These models mainly deal with instantaneous processes involved in resource acquisition and use (e.g transpiration and/ or photosynthesis) and study the interactions between these processes and ... provide a comprehensive review of (i) the processes involved in the short-term interactions between the tree foliage and the aboveground environment and (ii) the way these interactions are represented...
Ngày tải lên: 08/08/2014, 14:22
Báo cáo y học: "Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases" ppt
... and drafted the manuscript KF supervised the study design, the statistical analysis, and the writing of the manuscript YY and AO carried out the cell culture experiments TS prepared the human samples ... real-time PCR The tissue expression of IL-32 was prominent in the spleen, the lung, and the peripheral white blood cells (Figure 1a) IL-32 was therefore expressed mainly in the lymphoid tissues and leukocytes ... cells, MoDCs, and synovial fibroblasts) We suppose that a positive feedback system between TNFα and IL-32 promotes the tissue inflammation in the synovium and the intestinal epithelium In this...
Ngày tải lên: 09/08/2014, 08:23
Báo cáo y học: "Lack of association or interactions between the IL-4, IL-4Rα and IL-13 genes, and rheumatoid arthritis" pptx
... homology with IL-4, and it stimulates proliferation and differentiation of B cells and induces IgE and IgM production The role played by these genes in RA susceptibility and severity is not clearly ... study we examined the potential role of IL-4, IL-13 and IL-4R SNPs in RA susceptibility and severity In addition, we also investigated epistasis between the IL-4 or IL-13 and their common receptor ... each candidate gene polymorphism using the nonparametric Kruskal-Wallis test LD and haplotype analysis To assess the extent of LD across the IL-4 and IL-13 genes, we calculated D' values The pair-wise...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: " Interactions between the increase in venous return and right ventricular functio" potx
Ngày tải lên: 12/08/2014, 19:22
the interactions between inflammasome activation and induction of autophagy following pseudomonas aeruginosa infection
... for the activation of the inflammasome and IL-1β production, a key cytokine in host defence The relationship between inflammasome activation and induction of autophagy is not clear Hypothesis and ... allows the bacteria to inject protein effectors into the host cell in one single step altering the function of the host cell and promoting survival of the bacteria (Salmond and Reeves, 1993) The ... inspiring clinical and scientific mentor and has always tried to help develop my career in the best possible ways I think I can honestly say through all the ups and downs, scientific and otherwise, I...
Ngày tải lên: 22/12/2014, 19:57
Tài liệu Báo cáo khoa học: Paradoxical interactions between modifiers and elastase-2 Patricia Schenker and Antonio Baici docx
... represents the rate in the presence of the two modifiers I and X, v0 represents the rate in the absence of modifiers, and r = [S] ⁄ Km The coefficients a, b and c are those in Scheme 1, and e = acX ... mm; the pH was 7.40 and 0.01% Triton X-100 was added to prevent adsorption of the enzyme to the cuvette The buffer was Interactions between modifiers and elastase-2 prepared and used at 25 °C The ... with the modifiers separately and then in various combinations of concentrations In the case of the sulfated polysaccharides, the effector molecules are constituents of the same sample, and their...
Ngày tải lên: 16/02/2014, 14:20
business and environmental risks spatial interactions between environmental hazards and social vulnerabilities in ibero-america
... beings They create most of the problems, and they are the ones that have the ability to solve them too This brings me to my visit to Buenos Aires last year where not only the beautiful parks and the ... Brazil and the United Kingdom over 2008 and 2009 Travelling expenses of the Latin American researchers, acquisition of the databases for elaborating the maps presented and the publication of the ... that of the other two countries These circumstances, together with the HDI data, have influenced the choice of these countries for analysis, since the level of economic development is one of the determining...
Ngày tải lên: 29/05/2014, 23:42
Báo cáo toán học: "interactions between forest stands and microclimate: Ecophysiological aspects and consequences for silviculture" pot
... frosts if the width is over twice the height of the surrounding stand, and if the wooded bands in between are narrow When they are perpendicular to the dominant winds they may accentuate the risk ... in the architecture of the tree [7] during the following year At the top of the crowns, where overall radiation and radiation useful for photosynthesis reach a maximum, the leaves are erect and ... erect and their inclination angle from the horizontal is very high; it declines, i.e the leaves approach the horizontal, further wirthin the crown and as overall radiation and active photosynthetic...
Ngày tải lên: 08/08/2014, 14:22
Báo cáo y học: " Structural similarity-based predictions of protein interactions between HIV-1 and Homo sapiens" pptx
... RT and MAPK1, gp41 and LCK, gp41 and PTPRC, and IN and PRKCH The other five interactions (RT and PIN1, p2 and MAPK1, p2 and YWHAZ, gp41 and PLK1, gp41 and MAPK1, gp41 and CLTC, IN and XPO1, and ... motifs [9,10] There are a greater total number of shared predictions between Evans et al and Tastan et al than between our results and either one of the others This may be due to the fact that ... many of the random predictions were annotated with the same GO cellular component term The entire procedure was repeated 1000 times The mean and standard error of the mean for each of the four...
Ngày tải lên: 12/08/2014, 04:20
Báo cáo y học: " Collaborative interactions between neutrophil elastase and metalloproteinases in extracellular matrix degradation in threedimensional collagen gels" pps
... In contrast, PGE2 reduced the amount of total MMP-1 and decreased the conversion of the 52 kDa form to the lower molecular weight forms in the presence of elastase Neither indomethacin nor PGE2 ... µM) was added to the medium Matrix metalloproteases and (MMP-2 and MMP-9) Culture media were harvested after 5, 10, 15 and 21 days under control conditions and, after days, in the presence of ... cleavage of the latent forms can result in generation of active proteases [24,25] The MMPs differ both in their substrate specificity and in their mechanisms of activation Since some members of the MMP...
Ngày tải lên: 12/08/2014, 18:20
Báo cáo y học: "Intracellular interactions between APOBEC3G, RNA, and HIV-1 Gag: APOBEC3G multimerization is dependent on its association with RNA" potx
... on the association between nonfluorescent N- and C-terminal fragments (NY and CY) of the monomeric yellow fluorescent protein that results in the reconstitution of YFP and fluorescence The NY and ... efficiently between A3G-CY and NY-A3G (193%) The differences in the efficiency of YFP fluorescence reconstitution may be due to the orientations of the NY and CY fusion proteins in the complexes When the ... HIV-1 replication in the absence of Vif, indicating that the presence of the P22 peptide did not interfere with the antiviral activity of the A3G protein On the other hand, the P22-H65R protein...
Ngày tải lên: 12/08/2014, 23:21
Retention of coastal cod eggs in a fjord caused by interactions between egg buoyancy and circulation pattern
... and the deepest part of the fjord is 574 m The main part of the fjord is 3.5 km wide, narrowing to 1.6 km toward the head The inner end of Sørfolda is divided into two main branches; the northern ... discharge for the four rivers used in the simulation is shown in Figure The upper panel shows the data from the Lakshola River during 1960 and 1989, whereas the lower panel shows the mean from the Laks˚ ... was calculated depending on the density difference between the egg and the surrounding water The vertical displacement was computed based on the buoyant velocity and the eddy diffusivity coefficient,...
Ngày tải lên: 04/09/2015, 12:48
Study of magnetic interactions between ferromagnet, antiferromagnet and superconductor
... probe the interactions between Nb and IrMn This was motivated by the fact that the exchange interaction between IrMn and NiFe is sensitive to the spin state of IrMn, and any change in the spin ... parameters are the exchange constant, the uniaxial anisotropy constant and the saturation magnetization Other input parameters are the domain sizes in x,y and zdirections and the cell size The number ... the surface, which is manifested in the strong exchange coupling between AFM and FM This exchange interaction between IrMn and NiFe is sensitive to the spin state of IrMn, and any change in the...
Ngày tải lên: 08/09/2015, 19:36
Tài liệu Báo cáo khoa học: Evidence for interactions between domains of TatA and TatB from mutagenesis of the TatABC subunits of the twin-arginine translocase docx
... Barrett and C Robinson between the TM spans of TatA and TatB, and between the amphipathic regions Finally, we have re-examined the numerous mutations made previously in TatA, B and C and we present ... expressing the various mutated subunits, and the data for the TatA and TatB mutants (expressed using the pBAD vector) are shown in Fig The expression of the wild-type tatABC from the pBAD-ABC ... because GFP and TorA are found predominantly in the periplasm The TatA ⁄ 3Gly mutant, on the other hand is blocked in export and no translocation activity can be detected The same applies to the TatA...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: Long-distance interactions between enhancers and promoters The case of the Abd-B domain of the Drosophila bithorax complex pdf
... only the reporter gene situated on the same side, relative to the boundary, of the construct However, when the combination of the PTS and the boundary is placed 3¢ to one of the reporter genes, the ... between the Abd-B promoter and the iab regions [13] The unusual properties of the tmr led to the hypothesis that it may be involved in a process that normally targets the iab regions to the Abd-B ... removal of which shifts the ratio between the strength (indicated by the thickness of the curved arrows) of the cis and trans interactions in favor of the latter An increase in the trans interaction...
Ngày tải lên: 20/02/2014, 01:20
Tài liệu Interactions Between Workers and the Technology of Production: Evidence from Professional Baseball doc
... (0.107) Yes Standard errors are in parentheses The symbol “∆” indicates the first difference between consecutive years in the variable for the same person The coefficient and standard error for ... robust to the inclusion or exclusion of the team’s batting performance Regarding the other control variables, they all have the expected signs and are generally significant for the batting and pitching ... measure The first column in the bottom panel uses the opposing team’s batting average as the dependent variable, and the results are very similar to those obtained using the ERA Therefore, the results...
Ngày tải lên: 22/02/2014, 09:20
Interactions between Aquaculture and the Environment pot
... Interactions between Aquaculture and the Environment Guide G Therapeutic and other Products Principle The use of therapeutants should be managed correctly to minimise possible detrimental effects on the ... depends on the capture of wild stocks Therefore, to minimise the interaction of capture-based aquaculture and the ecosystem, there is the need for research about how to close the life cycles of the ... measures; the use of feed fish from all around the world; the equitable use of resources; the impact on the local environment; the compliance with regional regulations; and others A clear and drastic...
Ngày tải lên: 29/06/2014, 02:20