... per standard-deviation increase in vitamin C/vitamin E intake before and after adjusting for energy intake, age, gender, and body mass index dOdds ratio of tibiofemoral bone marrow lesions being ... of vitamin C and fruit on bone structure The lutein and zeaxanthin intake was associated with a decreased risk of cartilage defects independent of vitamin C intake, and β-cryptoxanthin intake ... standard-deviation increase in vitamin C/vitamin E intake before and after adjusting for energy intake, age, gender, body mass index, and tibial plateau bone area ratio of tibiofemoral cartilage defects being...
Ngày tải lên: 09/08/2014, 10:20
... containing bone morphogenetic protein (BMP-2) and/ or nanoparticles of hydroxyapatite (nHAp) using electrospinning, and showed its ability in inducing in vitro bone formation from human bone marrow-derived ... developed in this research will be described in details in one chapter, with a specific introduction and objectives presented in the beginning In Chapter 3, two kinds of protein loading methods into ... scaffolds in vivo • Optimizing the delivery of plasmid DNA encoding bone morphogenetic protein-2 (BMP-2) • Probing the performances of three kinds of delivery methods of plasmid DNA encoding BMP-2 in...
Ngày tải lên: 14/09/2015, 08:41
Applications of electrospinning and supercritical carbon dioxide foaming techniques in controlled release and bone regeneration 2
... processes (for instance emulsification and electrospinning as well as post-processing conditions like scaffold handling and incubation) that may result in partial removal of amino acid groups and conformation ... Protein integrity and secondary structure testing results In order to examine whether there is a loss in protein integrity through the loss of amino acid groups or structural damage caused in the ... objective of the research project is to conduct an in vitro study of recombinant BMP2 encapsulated in fibrous scaffolds by investigating the effects of HAp content and the different methods of protein...
Ngày tải lên: 14/09/2015, 08:41
Applications of electrospinning and supercritical carbon dioxide foaming techniques in controlled release and bone regeneration 3
... healing without transferring bone tissues Among this group of proteins, BMP-2 has been shown to induce healing in segmental bone defects Aebli and colleagues (Aebli et al., 2005) and Saito and ... color staining detected in bone fragments can be seen as the formation and growth of new blood vessels H&E staining analysis above has shown bone healing after treatment of all scaffolds Since the ... scaffolds obtained from the electrospinning method, 15mg of each sample of F1-F4 were weighed and dissolved in mL of DMF solution to extract DCM after freeze drying for days inside a Martin Christ...
Ngày tải lên: 14/09/2015, 08:41
Applications of electrospinning and supercritical carbon dioxide foaming techniques in controlled release and bone regeneration 4
... distinct bands present on the gel (Figure 5.6) In other words, the released DNA has survived both the electrospinning process and postprocessing conditions (handling of scaffold, incubations, and ... because of their release properties and morphology We further explored the in vitro study of plasmid DNA by investigating the effects of HAp content and the different methods of DNA loading on ... integrating well with the PLGA, adopting an efficient composite structure of inorganic-organic system as observed in natural bone The mechanical properties of the scaffolds fabricated using different...
Ngày tải lên: 14/09/2015, 08:41
Applications of electrospinning and supercritical carbon dioxide foaming techniques in controlled release and bone regeneration 5
... previous Xray and H&E staining results, in which significant bone healing is observed for samples A1, B1, B3, and C1 Furthermore, this also confirms that during the progress of bone healing, tissue ... indicate that the bioactivity of BMP-2 plasmid released from Chapter 129 all the three kinds of scaffolds was well maintained, which helped improve the formation of new bone and the healing of ... loading methods of BMP-2 plasmid and different HAp contents in scaffolds will alter the release profiles of BMP-2 plasmid, and consequently influence its performance in bone regeneration in vivo Figure...
Ngày tải lên: 14/09/2015, 08:41
Applications of electrospinning and supercritical carbon dioxide foaming techniques in controlled release and bone regeneration 6
... are maintained after going through the processes of spray drying, supercritical CO2 foaming and post-processing conditions (handling of scaffold, incubations, and lyophilization) As shown in Figure ... cases of scaffolds F1 and F2 To evaluate the effects of the fabrication process (including spray drying, supercritical CO2 foaming, and handling of samples) on the molecular integrity of plasmid ... microparticles and microfibers (Xie and Wang, 2007; Nie and Wang, 2007) In contrast, the release profiles of F1 and F2 are significantly different from that of F0 They released DNA at a lower rate in the initial...
Ngày tải lên: 14/09/2015, 08:41
Applications of electrospinning and supercritical carbon dioxide foaming techniques in controlled release and bone regeneration 7
... an initial and significant release of DNA is demanded in order to optimize this kind of devices Lysine, an α-amino acid of chemical formula HO2CCH(NH2)(CH2)4NH2, pKa 10.54 and hydrophobility of ... followed by a period of slow release profile Compared with the release profile of F0, the release profiles of F1 and F2 are relatively linear and sustainable The constant rate of the in vitro release ... Lysine-based peptides modified foams for tissue engineering and DNA delivery Toward realizing an effective dual system for tissue engineering and DNA delivery, our work presents intriguing findings...
Ngày tải lên: 14/09/2015, 08:41
Applications of electrospinning and supercritical carbon dioxide foaming techniques in controlled release and bone regeneration 8
... results indicate that the bioactivity of BMP-2 plasmid released from all the three kinds of scaffolds was well maintained, which helped improve the formation of new bone and the healing of segmental ... PLGA/chitosan and PLGA/Lysine composites is in form of naked DNA and its transfection efficiency is extremely low, which would hinder their applications in biomedical engineering In future investigations, ... sustained release of DNA, possibly due to a balance of electrostatic interaction and hydrophilic interaction between DNA and the surface of Lysine pepetide modified foams The sustained release of...
Ngày tải lên: 14/09/2015, 08:41
Báo cáo y học: "Antiviral therapy of HCV in the cirrhotic and transplant candidate"
... more aggressive dosing of interferon and ribavirin [13, 14] Finally, growing experience with antiviral therapy in this high-risk group has led to novel approaches and increasing success Table ... Duration of therapy was intended to be 24 weeks in genotypes and and 48 weeks in genotype infection Hematologic inclusion criteria included ANC > 800 cells/mL, hemoglobin > 10 g/dL and platelets ... Despite the use of G-CSF and erythropoietin, dose reduction of interferon was required in 60%, while ribavirin dose was decreased in 23% of study patients Everson and colleagues offer the largest series...
Ngày tải lên: 31/10/2012, 17:11
The role of language in adult education and poverty reduction in Botswan
... enables it to disseminate information, encourage participation in the education and economy of the communities To achieve its goal of disseminating useful information and eradicating poverty the ... Planning language, planning inequality: language policy in the community, London, Longman Rachal J R (1989), ‘The social context of adult and continuing education,’ in Merriam S B and Cunningham ... learning activities through which members of a society gain access to this information and to these skills The only way for this to be effected in multilingual societies is by means of a bilingual...
Ngày tải lên: 05/11/2012, 16:27
Tài liệu Faultlines of Conflict in Central Asia and the South Caucasus - Implications for the U.S. Army docx
... deterioration of some of its nuclear forces, command and control and warning systems, and nuclear infrastructure; and the general failure of Russian economic and political reforms pose xvi Future Roles of ... interpretation of both the crude Chinese nuclear threats over the Taiwan crisis and Chinese views of the U.S bombing of the Chinese embassy in Yugoslavia If the strategic views of China and the United ... creation of the Strategic Integrated Operational Plan (SIOP) in 1960 The SIOP was intended to bring some order to the targeting process and integrate the burgeoning nuclear forces of the different...
Ngày tải lên: 17/02/2014, 11:20
Tài liệu Research " THE ROLE OF EDUCATION IN ECONOMIC TRANSITION AND POLITICAL TRANSFORMATION IN POST-COMMUNIST COUNTRIES " ppt
Ngày tải lên: 18/02/2014, 11:20
Tài liệu Báo cáo Y học: A Raman optical activity study of rheomorphism in caseins, synucleins and tau New insight into the structure and behaviour of natively unfolded proteins pot
... a-synuclein and the A30P and A53T mutants, as well as in b- and c-synuclein, is PPII helix ROA measurements on tau protein Six isoforms of tau protein, ranging from 352 to 441 amino acids in length, ... observed in the caseins [3], synucleins [10], tau [14], prothymosin a [7] and the ®bronectin-binding protein [8], and also in typical chemically denatured proteins [56±58] Over extensive lengths of ... and jcasein ROA bands are therefore assigned to PPII structure The positive ROA bands in b- and j-casein at » 1290± 1295 cm)1 may originate in other types of loops and turns A negative ROA band...
Ngày tải lên: 21/02/2014, 15:20
Báo cáo khoa học: Alternative splicing: role of pseudoexons in human disease and potential therapeutic strategies pot
... recognition in the normal splicing process [55] First, U1snRNP binding to an intronic splicing processing element has been found to inhibit pathological pseudoexon inclusion in intron 20 of the ATM ... deletion abolished binding of an U1snRNP molecule in this position and activated a 3¢ss lying 12 nucleotides upstream of this element In the last case, binding of hnRNP E1 and U1snRNP to a silencer ... (even in the absence of a complete or even partial understanding of the ‘basic science’ explaining their occurrence) From a therapeutic point of view, the major advantage of targeting pseudoexon inclusion...
Ngày tải lên: 06/03/2014, 09:22
NOTES ON THE ROLE OF EDUCATION IN PRODUCTION FUNCTIONS AND GROWTH ACCOUNTING pot
... types) and imposes very few restrictions on it An interpretation of E as an index of embodied quality in different types and vintages of labor, fixed once and for all and independent of levels of ... does it best There is, of course, a great deal of evidence that differences in schooling are a major determinant of differences in wages and income, even holding many other things constant.8 Also, ... an increase in the number of plumbers results in a larger increase in total "real" labor input than a similar increase in the number of clergymen We can illustrate the construction of such indexes...
Ngày tải lên: 06/03/2014, 21:20
Báo cáo khoa học: Expression of cholinesterases in human kidney and its variation in renal cell carcinoma types pdf
... erythrocytes in the extent of binding with the lectins concanavalin A, Lens culinaris agglutinin 4522 (LCA), and Ricinus communis agglutinin (RCA) (Fig 3), ruled out the blood origin and supported ... cytochemical staining of acetylcholinesterase in the capsule of Bowman [41] and of acetylcholinesterase and butyrylcholinesterase in the glomerulus and the tubule, which is stronger for acetylcholinesterase ... responses The origin of pRCC in the tubular epithelium [54] and the presence in it of muscarinic and nicotinic receptors [34,55] support a role for ACh in renal tubules The increase in cholinesterase...
Ngày tải lên: 06/03/2014, 22:21
Selection and Breeding of Cattle in Asia: Strategies and Criteria for Improved Breeding pdf
... and training of both farmers and professionals and efficiently be under the responsibility of government Government involvement in supplying plant genetic material in the form of forage cuttings ... first calving (AFC) and long intervals between calving, especially in Bos indicus cows and riverine buffaloes, have been often cited as constraints to profitability in cattle farming in the SAP ... importance of these traits will be different in different areas and is important in determining the final breeding objectives BREEDING OBJECTIVES In the strictest theoretical sense, breeding goals and...
Ngày tải lên: 08/03/2014, 23:20
Doctor of Philosophy in Mathematics Linear and Non-linear Operators, and The Distribution of Zeros of Entire Functions
... one of the following conditions holds: (1) f and g have interlacing zeros with form (i) or (iv) in Definition 22 and the leading coefficients of f and g are of the same sign, or (2) f and g have interlacing ... lie in a convex region K containing the origin, and if all the zeros of g(z) lie in (−1, 0), then the zeros of h(z) also lie in K (iii) If the zeros of f (z) lie in (−a, a) and the zeros of g(z) ... enthusiasm, and support throughout the years of my studies The completion of this dissertation is mainly due to the willingness of Dr Csordas in generously bestowing me countless hours of advice and insight...
Ngày tải lên: 10/03/2014, 16:15
Use of Biotechnology in Agriculture — Benefits and Risks
... yield-reducing weeds in soybean fields without harming the crop CTAHR — May 2003 What are the benefits of genetic engineering in agriculture? Everything in life has its benefits and risks, and genetic ... consumer-advocate and envi ronmental groups have demanded the abandonment of genetic engineering research and development Many individuals, when confronted with conflicting and con fusing statements ... view of the fundamentals of biotechnology and genetic engineering, the processes used in developing transgenic organisms, the types of genetic material used, and the benefits and risks of the...
Ngày tải lên: 13/03/2014, 21:48