innate and acquired immune proteins in saliva
Báo cáo y học: " Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection" docx
Ngày tải lên :
13/08/2014, 20:22
... Germany) and subsequently incubated for 15 minutes in the dark with the monoclonal antibodies anti-CD3, anti-CD14 and anti-CD19, and the protein ANNEXIN-V at the fluorochrome fluorescein isothiocyanate ... Athens, Greece; and Wyeth Hellas SA The funding bodies did not have any role in study design, in collection, analysis, and interpretation of data, in writing the manuscript, or in the decision ... comprising history, thorough physical examination, blood cell counts, blood biochemistry, blood gas, blood culturing from peripheral and central lines, urine cultures, chest x-ray, and chest and...
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Báo cáo y học: "The role of leptin in innate and adaptive immune responses" doc
Ngày tải lên :
09/08/2014, 08:22
... (reviewed in [27]) and, in particular, the role of leptin in immune responses and inflammation has lately become increasingly evident Altered leptin production during infection and inflammation ... protein inhibitor of activated STAT3; Raf, MEK-kinase; Ras, G-protein; SHP-2, SH2-domain containing protein tyrosine phosphatase; SOCS3, suppressor of cytokine signalling-3 inflammatory and anti-inflammatory ... factors, including adipocytokines, such as leptin, adiponectin and resistin, as well as cytokines and chemokines Altered levels of different adipocytokines have been observed in a variety of inflammatory...
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Control of Innate and Adaptive Immune Responses during Infectious Diseases ppt
Ngày tải lên :
05/03/2014, 23:20
... binding to the intracellular domains of cytokine or hormone receptors, thereby blocking activation of downstream signaling pathways (Alexander and Hilton 2004) On the other hand, these proteins ... apoptosis induction and resulting in improved CD8 T cell induction (Hinchey et al 2007) On the other hand, Flt3-ligand-expressing BCG had no effect in improving protection (Triccas et al 2007) Interestingly, ... the CCR5-binding cyclophillin-18 and the TLR11-activating profillin IL-12 promotes the differentiation and proliferation of type 1, IFN- -producing T cells (CD4+ and CD8+) and NK cells In turn,...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
Ngày tải lên :
07/03/2014, 01:20
... nuclear actin-binding proteins interacting with the androgen receptor AR, androgen receptor; LBD, ligand-binding domain Actin-binding protein Targeting sequence Gelsolin Direct or indirect association ... Direct a-actinin-2 ()) Bundling proteins Coactivator Supervillin NLS F-actin- and membraneassociated scaffolding protein Filamin NLS? Cross-linking proteins Filamin A NLS? Cross-linking proteins Transgelin ... members of the actin-binding LIM protein (ABLIM) family, ABLIM-2 and -3, as STARS-interacting proteins These novel proteins contain four LIM domains and a C-terminal villin headpiece domain, which mediates...
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Báo cáo khoa học: Functional interplay between viral and cellular SR proteins in control of post-transcriptional gene regulation pptx
Ngày tải lên :
23/03/2014, 06:20
... SR proteins, together with other RNA-binding proteins, coordinate the coupling of splicing and polyadenylation Viral and cellular SR proteins enhancers of mRNAs [62] In addition, SR proteins ... function in pre-mRNA splicing Indeed, an EV HPV E2 protein interacts with cellular splicing factors, including prototypical SR proteins and RS domain-containing small nuclear ribonucleoprotein (snRNP) ... kinases, including cyclin-dependent kinases, GSK, casein kinase II, mitogen-activated protein kinases, and SRPKs, may phosphorylate coronavirus N proteins [11,12] We have Several viral proteins...
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Báo cáo y học: "Eggshell and egg yolk proteins in fish: hepatic proteins for the next generation: oogenetic, population, and evolutionary implications of endocrine disruption" pptx
Ngày tải lên :
13/08/2014, 13:20
... hepatic synthesis of eggshell proteins, zona radiata proteins (Zrp), their secretion and transport in blood to the ovary and uptake into maturing oocytes Terminology In fish, the major portion of ... cleavage and processing of Vtg into oocyte yolk proteins and lipids is mediated by serine proteases and cathepsins found in ovary extracts [21,94] After uptake, the Zrp monomers are cross-linked ... reviewing available methods for detecting endocrine disrupting effects of chemicals in wildlife, including fish An implementation of Vtg as a core endpoint in a piscine shortterm endocrine disrupter...
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The study of interactions of transmembrane receptors and intracellular signaling proteins in live cells by fluorescence correlation and cross correlation spectroscopy
Ngày tải lên :
14/09/2015, 14:25
... C-terminus domain, to expose binding sites for Src-homology-2 (SH2) domain-containing proteins and phosphotyrosine-binding (PTB) domain-containing proteins Adaptor proteins with a SH2-binding domain such ... epitope tag heparin-binding epidermal growth factor protein kinase C-related kinase homology region IQ motif containing GTPase activating protein infrared insulin receptor tyrosine kinase substrate ... protein kinases, actin-associated proteins and adaptor proteins (65) Many of the effectors contain a conserved 18 amino-acid binding motif which is named CRIB (for Cdc42-Rac interactive binding)...
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Sterol rich membrane domains and membrane associated proteins in the fission yeast schizosaccharomyces pombe
Ngày tải lên :
15/09/2015, 17:09
... by the finding that two proteins residing in nonoverlapping, separate microdomains in the plasma membrane of S cerevisiae are both detergent-insoluble (Malinska et al., 2003) indicating that ... cells at 36°C Arrows indicate strong medial staining in (A) and faint medial staining in (C) and (D) Arrowheads indicate additional asymmetric patches of sterol-rich membrane 33 In order to address ... cytokinetic protein, here shown to be membrane associated, to actomyosin ring assembly and maintenance at different stages of mitosis, we provide new insight into the roles of lipids and proteins...
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Clinical significance of cancer stem cell markers and other related proteins in colorectal carcinomas biological and methodological considerations
Ngày tải lên :
03/10/2015, 20:57
... metastatic adenocarcinoma as proposed by Fearon and Vogelstein (Fearon and Vogelstein, 1990) Figure A simplified working model of sporadic colorectal tumour development incorporating the CIN and CIMP pathways ... The MLH1 and MSH2 protein are essential in the mismatch repair machinery and mutations in MLH1 and MSH2 have been implicated in HNPCC (Boland et al., 1998) Many colorectal cancers with an intact ... inhibiting TYMS that causes depletion of thymidines and disruption DNA and RNA synthesis As a result, the cell undergoes apoptosis by “thymineless” death Interestingly, part of the interest in...
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Tài liệu Báo cáo khoa học: Characterization of chitinase-like proteins (Cg-Clp1 and Cg-Clp2) involved in immune defence of the mollusc Crassostrea gigas docx
Ngày tải lên :
19/02/2014, 00:20
... Crassostrea gigas [5] Interestingly, this protein, named C gigas chitinase-like protein (CgClp1) was found to be involved in the control of growth and remodelling processes in a manner similar ... mainly expressed during larval metamorphosis, in the mantle edge and the digestive gland During the reproductive cycle, expression was high in gonads during the postspawning period but not in ... blocked by incubating sections in 0.3% hydrogen peroxide in methanol for 30 at room temperature Slides were then washed and incubated in a blocking solution according to the manufacturer’s instructions...
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báo cáo hóa học: " Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo" doc
Ngày tải lên :
19/06/2014, 22:20
... Mechanisms of prostaglandin E2-induced interleukin-6 release in astrocytes: possible involvement of EP4-like receptors, p38 mitogen-activated protein kinase and protein kinase C J Neurochem 2001, ... likely include free radicals generated principally by NADPH oxidase, MPO, and inducible nitric oxide synthase (iNOS) in combination with cytokines and chemokines TLR-4 is the receptor for LPS in ... ligands while others are enzymes that catalyze the formation of receptor ligands that in turn activate secondary autocrine and paracrine signaling cascades These signaling events culminate in...
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Báo cáo y học: "Toll-like receptors and innate immune responses in systemic lupus" docx
Ngày tải lên :
09/08/2014, 10:21
... transforming growth factor-β and IL-10 In addition, Gas-6 on apoptotic cells binding to receptor kinases of Tyro family (mer, tyro and axl) downregulate inflammatory cytokines, IL-12 and TNFα during ingestion, ... adaptive and innate immune systems in both responding to infections and inducing autoimmunity Theapeutic implications Toll-like receptors as therapeutic targets As data linking TLR activation and ... acid/protein complexes, which can serve as both immunogens and adjuvants Innate immune sensors The nucleic acid binding TLRs appear to play pivotal roles in SLE TLR7 and TLR8 bind to single-stranded...
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Báo cáo y học: "Human metapneumovirus induces more severe disease and stronger innate immune response in BALB/c mice as compared with respiratory syncytial virus" pps
Ngày tải lên :
12/08/2014, 15:20
... of HMPV and viral titers were determined in nasal turbinates and lungs at the indicated time points (B) Comparison of HMPV and RSV titers measured on day and p.i in nasal turbinates and lungs ... commission Cell lines and viruses Rhesus monkey kidney cells (LLC-MK2 and Vero) were maintained in D-MEM supplemented with 10% FCS, 1% L-glutamine, and penicillin/streptomycin (complete medium) and Eagles's ... admixed with fibrin (D) Immunohistochemical staining for HMPV Groups of intraalveolar macrophages and pneumocytes expressing HMPV antigens (A to D): hematoxylin-eosin staining, original magnification...
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Báo cáo y học: "Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis" ppsx
Ngày tải lên :
12/08/2014, 19:21
... component C4b-binding protein is upregulated in inflammation, and binds and inactivates protein S Protein S is an endogenous coagulation inhibitor that enhances the activity of APC as an inhibitor ... self/non-self recognition in the innate immune system These include the serum complement [11], C-reactive protein (CRP) [10], mannose binding lectin [9], LPS-binding protein (LBP), and soluble CD14 [12] ... terminus of peptides and proteins In the case of fibrin, removal of carboxyl-terminal lysine residues renders the fibrin less sensitive to lysis by decreasing the ability of plasminogen and tissue-type...
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Báo cáo y học: " The innate immune repertoire in Cnidaria - ancestral complexity and stochastic gene loss" pptx
Ngày tải lên :
14/08/2014, 20:22
... domain structures of TIR domain-containing proteins identified in selected Cnidaria Summary of domain structures of TIR domain-containing proteins identified in selected Cnidaria nomic) and a ... Perforin domain containing proteins MACPF MPEG Tx-60A / Hy-MAC SigP MACPF EGF SigP Apextrin (k) MACPF (l) (m) (n) (o) Figure Complement component C3 and MAC/PF domain-containing proteins in Cnidaria ... attack complex/perforin domain (MAC/PF) similar to that present in complement component C6 and related proteins HMM searching identified just two MAC/PF domain-containing proteins in Hydra (Table...
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Tài liệu Báo cáo khoa học: Multifunctional host defense peptides: Antimicrobial peptides, the small yet big players in innate and adaptive immunity docx
Ngày tải lên :
18/02/2014, 06:20
... b-defensins participate in the triggering of an immune response and in the natural process of elimination of activated antigen-presenting cells and termination of the immune response [90] Healing Infection ... numbers in the locus of b-defensin in chromosome As a result of this deficiency in a-defensins and b-defensins, luminal microbes invade the mucosa and trigger in ammation [104] Concluding remarks Initially ... Gram-negative bacteria and Trypanosoma cruzi Similar to defensins, cathelicidins participate actively in linking innate and adaptive immunity and in modulating the amplitude of immune responses [14]...
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
Ngày tải lên :
18/02/2014, 16:20
... imported + ⁄ 1A1 and + 33 ⁄ 1A1 proteins were extractable with alkaline Na2CO3 as shown in Fig 2C, suggesting that both proteins are localized in the matrix compartment in a membrane-extrinsic topology ... cleave the N-termini of CYP2E1 and CYP2B1 [6,12] In the case of CYP2B1 and CYP2E1, uncleaved intact proteins were targeted to the mitochondria in both inducer-treated rat liver and transiently ... receptors (TOM20, TOM22 and TOM70), which enables the translocation of proteins through the outer membrane and the inner membrane channel-forming proteins, TOM40 and translocase of inner membrane 23...
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Tài liệu Báo cáo khoa học: DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner pptx
Ngày tải lên :
19/02/2014, 05:20
... sequence-specific binding of p53 or p73 proteins to a 50-mer oligonucleotide (oligo) involving the p53 DNA-binding sites (p53DBSs) (A) The 32P-labeled p21 target was incubated with the given protein in presence ... autoradiogram showing retarded bands due to binding of p53(1–363) or p73d proteins to 50-mer target oligos containing PGM1, PGM4, mdm2, p21, p21a and p21b sites Other details as in (A), lanes and FEBS ... protein was decreased due to formation of cisplatin adducts within the p53 DNA-binding site (p53DBS), resulting in increased p53 binding to the labeled probe The pPGM4 fragment (c) contains cisplatinresistant...
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Báo cáo khoa học: Two overlapping antiparallel genes encoding the iron regulator DmdR1 and the Adm proteins control sidephore and antibiotic biosynthesis in Streptomyces coelicolor A3(2) pdf
Ngày tải lên :
07/03/2014, 02:20
... actinorhodin and undecylprodigiosin, suggesting that interaction of these two proteins plays an important role in the control of secondary metabolism (including production of desferrioxamines and ... TAadm and DdmdR1 ⁄ adm, and the lower reaction intensity in TAdmdR1 strains Six micrograms of total protein were loaded in each lane indeed abundant in the wild-type strain and that it is absent in ... TAdmdR1 in R5 or TBO solid media was still intense, in contrast to the results for MS medium, in which the pigmentation was much lower Actinorhodin and undecylprodigiosin production in these strains...
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Báo cáo khoa học: Structural and functional evidence for a singular repertoire of BMP receptor signal transducing proteins in the lophotrochozoan Crassostrea gigas suggests a shared ancestral BMP/activin pathway docx
Ngày tải lên :
07/03/2014, 21:20
... serine ⁄ threonine kinase domain in both proteins is encoded by two exons equivalent to kinase subdomains X and XI [22] In addition, the GS box and L45 loop of Cg-BMPR1, as well as the C-terminal ... BMP ligands exclusively, and in Drosophila phenotypes arising from mutations in the gene encoding wishful thinking, wit, suggest a role for this protein in synapse regulation and ⁄ or maintenance ... superfamily, which includes bone morphogenetic proteins (BMPs), activin and activin-like proteins such as nodal and their receptors, has been implicated in multiple processes during animal development...
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