© 2009 by the american college of chest physicians
báo cáo khoa học: " Comparison of hyperthermia and adrenaline to enhance the intratumoral accumulation of cisplatin in a murin model of peritoneal carcinomatosis" potx
... should assess the effect of hyperthermia; that of groups and should assess the effect of adrenaline; and that of groups and should assess the effect of the duration of IPC A 2- Page of hour HIPEC ... reflect the extra-abdominal tissues, half of the left kidney, and about 200 mg of the anterior edge of the liver were sampled and kept at -80° C until the platinum assay The comparison of groups ... followed the “Guidelines on the protection of experimental animals” published by the Council of the European Community (1986) The Burgundy’s University Animal Care and Use Committee approved all of the...
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Báo cáo y học: "New onset diabetes complicated by haemolysis and rhabdomyolysis: a case report and review of the literature" pot
... dehydrogenase Competing interests The authors declare that they have no competing interests Authors' contributions Both of the authors were involved in the writing of the manuscript and patient clinical ... available for review by the Editor-in-Chief of this journal Additional material Additional file Renal function during the 22 days of admission Renal function as demonstrated by creatinine levels ... and following administration of metformin [7] or glibenclamide [8] The precipitant of the haemolysis is not clear in this case and may have involved a combination of infection, gliclazide and...
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báo cáo hóa học:" Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC)" pptx
... express the protein of interest while others either expressed high, moderate or very low levels of the proteins We determined band intensities for the expressed proteins by scanning the films ... Understanding the biodistribution of these drugs during peritoneal perfusion of chemotherapy is important in order to predict the occurrence of these adverse side effects and determine the risk:benefit ... treatment condition The greatest accumulation of Pt was observed in the kidney, the site of Pt elimination Likewise, greatest level of arsenic was observed in the liver, the organ for arsenic...
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Báo cáo hóa học: " Synthesis of Bio-Compatible SPION–based Aqueous Ferrofluids and Evaluation of RadioFrequency Power Loss for Magnetic Hyperthermia" docx
... [31] studied the variation of SAR with the where m is the magnetic moment of the particle, V the particle volume, s the relaxation time, H is the strength of the magnetic field and x is the angular ... most recommended because of its higher magnetization values, lesser toxicity [19] and the ease of metabolism by the liver In the present study, we report the synthesis of highly stable water-based ... to supersaturate for the precipitation of the oxide The rate of reaction was controlled by allowing one drop of ammonia per second to react with this solution until a pH of 10, to get a thick...
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Chapter 017. Fever and Hyperthermia (Part 1) docx
... shift of the set point from "normothermic" to febrile levels very much resembles the resetting of the home thermostat to a higher level in order to raise the ambient temperature in a room Once the ... matches the new thermostat setting Once that point is reached, the hypothalamus maintains the temperature at the febrile level by the same mechanisms of heat balance that function in the afebrile ... afebrile state When the hypothalamic set point is again reset downward (in response to either a reduction in the concentration of pyrogens or the use of antipyretics), the processes of heat loss through...
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Chapter 017. Fever and Hyperthermia (Part 2) docx
... distinguished by the presence of diarrhea, tremor, and myoclonus rather than the lead-pipe rigidity of the neuroleptic malignant syndrome Thyrotoxicosis and pheochromocytoma can also cause increased thermogenesis ... 40.5°C Hyperthermia is often diagnosed on the basis of the events immediately preceding the elevation of core temperature— e.g., heat exposure or treatment with drugs that interfere with thermoregulation ... often fatal The neuroleptic malignant syndrome occurs in the setting of neuroleptic agent use (antipsychotic phenothiazines, haloperidol, prochlorperazine, metoclopramide) or the withdrawal of...
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Chapter 017. Fever and Hyperthermia (Part 3) pot
... are released from the cells and enter the systemic circulation Although the systemic effects of these circulating cytokines lead to fever by inducing the synthesis of PGE2, they also induce PGE2 ... by the lung and gains access to the hypothalamus via the internal carotid However, it is the elevation of PGE in the brain that starts the process of raising the hypothalamic set point for core ... pass from the circulation into the brain itself Thus, it appears that both exogenous and endogenous pyrogens interact with the endothelium of these capillaries and that this interaction is the first...
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Chapter 017. Fever and Hyperthermia (Part 4) potx
... psoriasis Does such therapy mask infection by preventing fever? With the increasing use of anticytokines to reduce the activity of IL-1, IL-6, IL-12, and TNF, the effect of these agents on the febrile ... neuronal cells synthesize IL-1, TNF, and IL-6 CNTF is also synthesized by neural as well as neuronal cells What role in the production of fever is played by these cytokines produced in the brain itself? ... infection.[newpage] APPROACH TO THE PATIENT: FEVER OR HYPERTHERMIA Physical Examination Attention must be paid to the chronology of events and to other signs and symptoms preceding the fever The temperature...
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Chapter 017. Fever and Hyperthermia (Part 5) pdf
... mediated by IL-1β, patients also respond to antipyretics Mechanisms of Antipyretic Agents The reduction of fever by lowering of the elevated hypothalamic set point is a direct function of reducing the ... of PGE2 in the thermoregulatory center The synthesis of PGE2 depends on the constitutively expressed enzyme cyclooxygenase The substrate for cyclooxygenase is arachidonic acid released from the ... release is the rate-limiting step in the synthesis of PGE2 Therefore, inhibitors of cyclooxygenase are potent antipyretics The antipyretic potency of various drugs is directly correlated with the inhibition...
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Chapter 017. Fever and Hyperthermia (Part 6) doc
... and the evolution of clinical thermometry Clin Infect Dis 18:458, 1994 ———, Wasserman SS: A critical appraisal of 98.6˚F, the upper limit of the normal body temperature, and other legacies of ... in the hyperthermia of the serotonin syndrome and thyrotoxicosis The neuroleptic malignant syndrome may also be treated with bromocriptine, levodopa, amantadine, or nifedipine or by induction of ... cardiopulmonary bypass with cooling of blood may be performed.Malignant hyperthermia should be treated immediately with cessation of anesthesia and IV administration of dantrolene sodium The recommended...
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Chapter 020. Hypothermia and Frostbite (Part 1) potx
... factors often compound these problems by impeding adequate measures to prevent hypothermia Neonates have high rates of heat loss because of their increased surface-to-mass ratio and their lack of ... many other medications reduce centrally mediated vasoconstriction Up to 25% of patients admitted to an intensive care unit because of drug overdose are hypothermic Anesthetics can block the shivering ... Shapiro syndrome, is one cause of episodic hypothermia, characterized by profuse perspiration followed by a rapid fall in temperature Acute spinal cord injury disrupts the autonomic pathways that...
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Chapter 020. Hypothermia and Frostbite (Part 2) pot
... depression of all organ systems The timing of the appearance of these clinical manifestations varies widely (Table 20-2) Without knowing the core temperature, it can be difficult to interpret other ... however, the presentation is often more subtle and other disease processes, toxin exposures, or psychiatric diagnoses should be considered After initial stimulation by hypothermia, there is progressive ... Presentation In most cases of hypothermia, the history of exposure to environmental factors, such as prolonged exposure to the outdoors without adequate clothing, makes the diagnosis straightforward...
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Chapter 020. Hypothermia and Frostbite (Part 3) doc
... type and severity of the precipitants of hypothermia There are no validated prognostic indicators for recovery from hypothermia A history of asphyxia with secondary cooling is the most important ... solution, as the liver in hypothermic patients inefficiently metabolizes lactate The placement of a pulmonary artery catheter risks perforation of the less compliant pulmonary artery Insertion of a central ... in the setting of depressed CO2 production When the PCO2 decreases 10 mmHg at 28°C, it doubles the pH increase of 0.08 that occurs at 37°C The severity of anemia may be underestimated because the...
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Chapter 020. Hypothermia and Frostbite (Part 4) pot
... placed in the left chest of a spontaneously perfusing patient for purposes of rewarming Peritoneal lavage with the dialysate at 40°–45°C efficiently transfers heat when delivered through two catheters ... some other forms of active core rewarming, it eliminates respiratory heat loss and adds 1°–2°C to the overall rewarming rate Crystalloids should be heated to 40°–42°C, but the quantity of heat ... or bladder transfers minimal heat because of the limited available surface area These methods should be reserved for patients in cardiac arrest and then used in combination with all available...
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Chapter 020. Hypothermia and Frostbite (Part 5) pdf
... presence of the sick euthyroid syndrome (Chap 335), historic clues or physical findings suggestive of hypothyroidism should be sought When myxedema is the cause of hypothermia, the relaxation phase of ... anesthesia and erythema The appearance of superficial vesiculation surrounded by edema and erythema is considered second degree (Fig 20-1) Hemorrhagic vesicles reflect a serious injury to the ... by hypothermia and reappear during rewarming None of the class I agents has proved to be safe and efficacious When available, bretylium tosylate was the class III ventricular antiarrhythmic of...
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SỐT (Fever and hyperthermia) potx
... mò, thương hàn, bệnh luput ban đỏ hệ thống - Sốt có kèm rét: sốt có kèm theo gai rét (rét ít) gặp đa số bệnh Sốt kèm theo rét run làm bệnh nhân phải đắp nhiều chăn bệnh sốt rét, nhiễm khuẩn ... qua men ATP-aza (Adenosin triphosphataza) Sinh nhiệt bắp có tầm quan trọng đặc biệt thay đổi tùy theo nhu cầu huy vỏ não (hữu ý) thần kinh tự động + Thải nhiệt: Thải nhiệt thể môi trường xung ... thương trung tâm điều hoà nhiệt thể người khả trì thân nhiệt ổn định lúc nhiệt độ thể biến đổi theo nhiệt độ môi trường xung quanh gọi tượng “biến nhiệt” Cơ chế bệnh sinh sốt Sốt phản ứng thể...
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báo cáo khoa học: "Inflammatory myopathy and severe rhabdomyolysis induced by leuprolide acetate therapy for prostate cancer: a case report" pot
... cancer treatment [7], the treatment of cancer in our patient resulted in the development of clinical signs of myopathy On the basis of his serum PSA and the fact that the size of the solitary node ... Page of and supervised the writing of the case report All authors were involved with the treatment of the patient, and all authors read and approved the final manuscript Competing interests The ... and MR contributed equally to the case report Both of them wrote the report and conducted the literature search PE contributed to the discussion Bergner et al Journal of Medical Case Reports 2011,...
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báo cáo khoa học: " Hypothyroidism in a five-year-old boy with rhabdomyolysis and recent history of cardiac tamponade: a case report" pptx
... images A copy of the written consent is available for review by the Editor-inChief of this journal Acknowledgements We would like to thank Dr Elizabeth Orellana of the Pathology Department of Esperanza ... providing the photograph of the biopsy as well as the Cardiovascular Surgery Unit (UNICAR) for providing the original echocardiogram report along with the photograph Matt Hodgkinson helped editing the ... hypothyroidism with the presence of pericardial effusion [2], which can be assessed by the short stature seen in our patient as well as the delayed bone age reported Our patient was evaluated by a rheumatologist,...
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Báo cáo y học: " Near fatal posterior reversible encephalopathy syndrome complicating chronic liver failure and treated by induced hypothermia and dialysis: a case report" pps
... cirrhosis as well as the first report of induced hypothermia for the management PRES and the use of CVVHD for control of hyperammonemia in a cirrhotic patient The pathogenesis of PRES remains incompletely ... protection of the fluidity of lipoprotein membranes, reduction in the oxygen demand in low flow regions, reduction in intracellular acidosis, and inhibition of the biosynthesis, release, and uptake of ... from the patient for publication of this case report and any accompanying images A copy of the written consent is available for review by the Editor-in-Chief of this journal Competing interests The...
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Báo cáo y học: "Hypothermia and neurologic outcome in patients following cardiac arrest: should we be hot to cool off our patients" pot
... delays of 15 and 30 preserved the beneficial effect of hypothermia, but with delays of 45 there was no attenuation of infarct volume [12] In dogs, delaying hypothermia by 15 obscured the benefit ... with the relative percentages presented in other studies In Fig the numbers of favorable outcomes from the normothermia arms of the two trials can be seen to approximate closely those of other ... summarizes some of the features of the two recent studies that examined the neuroprotective advantage of hypothermia in treatment of cardiac arrest ICU, intensive care unit; ROSC, restoration of spontaneous...
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