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Báo cáo khoa học: The leech product saratin is a potent inhibitor of platelet integrin a2b1 and von Willebrand factor binding to collagen pdf
Ngày tải lên :
30/03/2014, 09:20
... 4A), consistent with the ability of saratin to block a2b1-mediated platelet binding It is noteworthy that this series of experiments was performed in the absence of inhibitors of ADP and TxA2 ... inhibitor [14–18] Furthermore, saratin has been shown to inhibit lumen stenosis in carotid endarterectomized rats [19] and to reduce platelet adhesion and intimal hyperplasia in both a nondiseased ... that saratin interferes with integrin a2b1 binding to collagen, in addition to inhibiting VWF–collagen binding, presumably by binding to an overlapping epitope on collagen This has significant implications...
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Tài liệu What Is Micromanagement? And What You Can Do To Avoid It. docx
Ngày tải lên :
24/01/2014, 09:20
... any decisions; and runs his/her office like a military command and control center When Is Micromanaging OK? To be fair, not all managers who are given this pejorative title deserve it It is the ... manager to monitor progress, control quality, evaluate performance, make decisions, give instruction, and offer advice and guidance For example: • If deadlines are missed or customers are not satisfied, ... member is not able to perform, a manager needs to become more involved in their work in order to coach them effectively • If a staff member is not willing to perform, a manager needs to monitor...
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Báo cáo khoa học: Kinetic studies and molecular modelling attribute a crucial role in the specificity and stereoselectivity of penicillin acylase to the pair ArgA145-ArgB263 pdf
Ngày tải lên :
16/03/2014, 16:20
... steric and electronic factors The structures listed in Table are of different size and hydrophobicity, without and with electronegative substituents of different orientation, and the majority possesses ... LeuB387 and TrpB240, Od1 atom of AsnB241 and Oc atom of SerB386 and is expected to stabilize the positive charge of ArgB263 The possible nonsymmetrical accommodation of substrates with respect to ... nonlinear regression data analysis software ENZFITTER [31] Modelling and analysis of interaction energies within the active site Initial graphic visualization and manipulation of molecules were...
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reading like a writer a guide for people who love books and for those who want to write them (p.s.)
Ngày tải lên :
09/05/2014, 12:41
... material out of which literature is crafted Written with passion, humor, and wisdom, Reading Like a Writer will inspire readers to return to literature with a fresh eye and an eager heart 0906 ... choice that a writer of fiction needs to make: the question of what to call her characters Joe, Joe Smith, Mr Smith? Not, in this case, Grandma or Grandma Smith (no one in this story has a last ... And then I happened to reread it not long after a death in my own family, and for the first time I understood that the sisters' perplexity is not so unlike the astonishment and bewilderment that...
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Báo cáo y học: "A cross-sectional study of the number and frequency of terms used to refer to knowledge translation in a body of health literature in 2006: a Tower of Babel?" pps
Ngày tải lên :
11/08/2014, 05:21
... Hospital, University of Toronto, 30 Bond Street, Toronto, ON, Canada 6Family and Community Medicine, and Health Policy, Management and Evaluation, St Michael’s Hospital, University of Toronto, 30 Bond ... science and practice of KT to advance, ready access to KT literature across disciplines is essential The KT literature is large and encompasses the spectrum of material from opinion pieces and editorials ... the statistical calculations unstable and we did not adjust for multiple statistical comparisons These statistical issues would act to show more discrimination than is potentially present, and strengthen...
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Báo cáo y học: " Epigenetic regulation: DNA confers identity but is not enough to maintain it" pps
Ngày tải lên :
14/08/2014, 16:20
... increasingly clear that many diseases are due to defects that are not genetically encoded, understanding these mechanisms and to what extent they apply to disease is of utmost importance Also, ... study of a novel histone modification, H3 K56 acetylation, and its role in the repair of doublestrand breaks in DNA K56 is located at the DNA entry/exit point in the nucleosome and is in an acetylated ... canonical histones with variant histones Steve Henikoff (Fred Hutchinson Cancer Center, Seattle, USA) used chromatin-affinity purification of histone variant H3.3 in combination with tiling microarrays...
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A study on the reality of teaching and learning English pronunciation skills to the 11th graders at Kien An high school =Nghiên cứu thực trạng dạy và học kỹ năn
Ngày tải lên :
28/03/2015, 09:33
... ability to hear foreign languages than others This skill has been variously termed "phonetic coding ability", "aptitude for oral mimicry" or "auditory discrimination ability" Attitude and identity ... developing listening and speaking skills not receive enough attention to It is this negative attitude towards pronunciation teaching that is one of the difficulties the teachers have to overcome ... stress or intonation This is quite understandable because more than 54% of the teachers said that they found stress is the most difficult part to teach, and about 45% thought it is intonation 28...
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Báo cáo khoa học: CmtR, a cadmium-sensing ArsR–SmtB repressor, cooperatively interacts with multiple operator sites to autorepress its transcription in Mycobacterium tuberculosis pptx
Ngày tải lên :
23/03/2014, 04:21
... with the F-1 fragment and lM of CmtR with no competitor (lane 2), with 50 · non-specific competitor [poly(dI-dC), lane 3], or with 10· (lane 4) and 50· (lane 5) self-competitor; lane contains labeled ... the proximity of Rv1993c and Rv1992c ⁄ cmtA ⁄ ctpG in the M tuberculosis genome (Fig 1A) cmtR was previously shown to be co-transcribed with Rv1993c and cmtA in M bovis [10] To establish that ... SDS–PAGE analysis of soluble His-CmtR under nonreducing condition shows that it forms dimers (approximately 32 kDa) and higher-order oligomers (Fig 6A,B) Bands corresponding to positions up to an octamer...
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In order to become competent in a foreign language, it is important for language learners not only to acquire new vocabularies and a new set of phonological and syntactic rules but also to learn what Wilson (1986)
Ngày tải lên :
17/04/2013, 16:09
... ngữ to n dân đòa phương cụ thể với nét khác biệt so với ngôn ngữ to n dân hay với phương ngữ khác “[8; 24] Ở đây, thấy cần phân biệt ngôn ngữ to n dân phương ngữ Phương ngữ biến thể ngôn ngữ to n ... chỉnh riêng “một nhánh tách từ thân cây” [8; 54] ngôn ngữ to n dân Ngôn ngữ to n dân trừu tượng phương ngữ cụ thể “Phương ngữ ngôn ngữ to n dân có mặt trừu tượng mặt cụ thể ” [8; 54] 1.1.4.1.2 ... diễn đạt Về ngữ pháp, ngôn ngữ to n dân phương ngữ có lẽ không khác Chính thống mặt ngữ pháp phương ngữ với với ngôn ngữ to n dân thếø tiếng Việt bảo đảm thống to n quốc “Khi việc miêu tả thu...
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Báo cáo Y học: Incorporation of 3-nitrotyrosine into the C-terminus of a-tubulin is reversible and not detrimental to dividing cells potx
Ngày tải lên :
17/03/2014, 10:20
... processed to compare the abilities of tyrosinated and nitrotyrosinated tubulin to assemble into and to disassemble from microtubules, by monitoring radioactivity and immunoreactivity (see Materials and ... stained with antibodies to Glu- and nitrotyrosinated tubulin by that of an identical sample stained with DM1A antibody Capabilities of nitrotyrosinated and Tyr-tubulin to assemble into and to disassemble ... that tyrosinated and nitrotyrosinated Table Capability of nitrotyrosinated tubulin to assemble into and disassemble from microtubules Assembly and disassembly were determined by monitoring each type...
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báo cáo hóa học:" HIV is a virus, not a crime: ten reasons against criminal statutes and criminal prosecutions" potx
Ngày tải lên :
20/06/2014, 08:20
... media-friendly But it is not preventionor treatment-friendly It is hostile to both This is because, tragically, it is stigma that lies primarily behind the drive to criminalisation It is stigma, rooted ... fear and blame and recrimination, criminalisation makes it more difficult for those with or at risk of HIV to access testing, to talk about diagnosis with HIV, and to receive treatment and support ... unworthy condition, requiring isolation and ostracism But HIV is a virus, not a crime That fact is elementary, and all-important Law-makers and prosecutors overlook it We must fight this new burden...
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Báo cáo khoa hoc:" Quantitative competitive reverse transcription polymerase chain reaction is not a useful method for quantification of CD4 and CD8 cell status during HIV infection" pptx
Ngày tải lên :
11/08/2014, 08:20
... Quantity of sample derived mRNA can be determined when the intensity of its PCR band is equal to that of the competitor's upon co-amplification Staining with ethidium bromide can be quantitative ... provided that digital imaging is employed [9] The standard curve plots the log cDNA/competitor band intensity (as determined by analysis of PICT files with NIH image) on the x-axis versus the log ... wild type PCR product was inserted into the TA cloning vector before digesting with BbsI, an enzyme with no recognition sites inside the vector and only one site in the insert The linearized plasmid...
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Báo cáo sinh học: "Second chromosome polymorphism of Drosophila buzzatii in a natural population is not associated with gametic selection and does not affect mating pattern" potx
Ngày tải lên :
14/08/2014, 20:20
... 1989 by means of banana baits and with Opuntia vulgaris rotting cladodes, in order to test the assumption that flies were not differentially attracted to the collecting baits RESULTS The frequencies ... selection against 2st would not affect our previous results ACKNOWLEDGMENTS The authors wish to thank to Dr OA Reig for helpful discussions and constructive criticisms of the manuscript Dr A ... are indebted to Dr G Tell and L M Giurfa for the French translation of the title and summary The English language of this paper was improved by the revision of Mr FJ Dyzenchauz The critical comments...
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Software Design and Development (A guide) is help you how to managed IT Project. Especially for Design and Develop software project.
Ngày tải lên :
15/10/2013, 23:13
... assigning tasks and responsibilities within a development organization Day - Definitions & Overview Why you use a CASE tool ? Its goal is to ensure the production of high-quality software, meeting ... Design Prototyping - its benefits Multiple prototyping tasks may be conducted to simultaneously to address various alternative design issues Can help resolve open issues ie Usercentred design issues, ... requirements and design issues D Day - Software Design Analyzing the requirements To ensure that requirement is complete Obvious requirements are documented so that design decision is not left to the...
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Tài liệu .An ARCO Book ARCO is a registered trademark of Thomson Learning, Inc., and is used herein under pptx
Ngày tải lên :
20/01/2014, 20:20
... ○ ○ ○ ○ ○ TO GUESS OR NOT TO GUESS” IS NOT AN ISSUE With a paper-based test, there is always the issue of whether it is a good idea to guess or not With the GMAT CAT, the question is simply irrelevant ... explaining its causes (B) outlining a position and supporting it with statistics (C) isolating an ambiguity and clarifying it by definition (D) presenting a problem and advocating a solution for it (E) ... Standard Written English Your task is to evaluate the grammar, logic, and effectiveness of a given sentence and to choose the best of several suggested revisions In questions of this type, either...
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Tài liệu Báo cáo khoa học: The plasminogen activator inhibitor 2 transcript is destabilized via a multi-component 3¢ UTR localized adenylate and uridylate-rich instability element in an analogous manner to cytokines and oncogenes pdf
Ngày tải lên :
16/02/2014, 09:20
... necrosis factor-mediated cytolysis by overexpression of plasminogen activator inhibitor type-2 J Biol Chem 266, 20960–20964 12 Lian X & Yang T (2004) Plasminogen activator inhibitor 2: expression and ... cytoplasmic extraction buffer (10 mm Hepes, pH 7.1, mm MgCl2, 14 mm KCl, 0.2% NP-40, mm dithiothreitol, supplemented with protease inhibitors (complete EDTA free; Roche) and phosphatase inhibitors ... [28,29,33] Discussion PAI-2 is a serine protease inhibitor and is a highly-regulated member of the plasminogen activator system, and is one of the most highly inducible genes known Its expression...
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Tài liệu Báo cáo khoa học: Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase d and S6K1 and regulating cell growth docx
Ngày tải lên :
19/02/2014, 05:20
... insert (with the stop codon) and the ER cDNA (without the first ATG codon and with the stop codon), respectively, into BamHI and NotI sites of pGEX-4T1 (Amersham, Little Chalfont, UK) in-frame with ... bound to glutathione-agarose beads and the recombinant full-length ER protein with a FLAG epitope tag at its C-terminus (Fig 3A) Western blot analysis with antibody raised against the FLAG epitope ... codon and with the stop codon) into EcoRI and XhoI sites of pHybLex ⁄ Zeo (Invitrogen) in-frame with LexA pQE30 ⁄ ER-FLAG was generated by inserting the ER cDNA (without the first ATG codon and with...
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Báo cáo khoa học: Expression of the Drosophila melanogaster ATP synthase a subunit gene is regulated by a transcriptional element containing GAF and Adf-1 binding sites pptx
Ngày tải lên :
07/03/2014, 16:20
... activity of this fragment is dependent of the GAF and Adf-1 regulatory proteins Both GAF and Adf-1 are ubiquitous transcription factors critical for Drosophila viability GAF is encoded by the trithorax-like ... biogenesis, the nuclear respiratory factors (NRFs) and [5,14] These factors are likely to be involved in the integration of mitochondrial biogenesis with other cellular processes related to cell ... regulatory circuits controlling mitochondrial biogenesis and function Genes Dev 18, 357–368 15 Scarpulla, R.C (2002) Nuclear activators and coactivators in mammalian mitochondrial biogenesis Biochim...
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