In the second edition of this book, we will explore the beautiful world of graphical user interfaces (GUIs) using the Python programming language. We will be using the latest version of Python 3. All of the recipes from the First Edition are included in this edition. We have added a few new recipes to the Second Edition, which you might not easily find via a Google search. I think these new recipes will be useful and interesting to the reader. This is a programming cookbook. Every chapter is selfcontained and explains a certain programming solution. We will start very simply, yet throughout this book we will build a working application written in Python 3. Each recipe will extend building this application. Along the way, we will talk to networks, queues, databases, the OpenGL graphical library, and many more technologies. We will apply design patterns and use best practices. The book assumes that the reader has some experience using the Python programming language, but that is not really required to successfully use this book. This book can also be used as an introduction to the Python programming language, if, and only if, you are dedicated in your desire to become a Pythonic programmer. If you are an experienced developer in any other language, you will have a fun time extending your professional toolbox by adding writing GUIs using Python to your toolbox.