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Diagnostic classification and relapse prediction in alcohol dependence using fmri from classification algorithm to imaging approach

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Cấu trúc

  • Cover

  • Contents

  • Zusammenfassung

  • Abstract

  • Chapter I: Introduction

    • Background

      • Alcohol dependence

        • Stages of addiction

        • Pathophysiology of alcohol dependence

          • Mesolimbic dopamine system

          • Imbalance between reward and antireward system

          • Role of alcohol cues

      • fMRI and classification techniques

        • fMRI data

        • fMRI analysis

          • Localization of brain activation

          • Connectivity

          • Classification/prediction

    • Aims

    • Methodology

  • Chapter II: Formation of functional ROIs

    • Introduction

    • Materials and methods

      • Materials

      • Methods

        • Step 1: Constructing the activation patterns

        • Step 2: Classifying the patterns

      • Evaluation

    • Results

    • Discussion

  • Chapter III: fMRI classification based on multiple lines of evidence

    • Introduction

    • Materials and methods

      • Materials

      • Methods

        • Classification of pattern

          • Observation on individual ROIs

          • Combination of the observation results

        • Classification of subject

      • Evaluation

    • Results

    • Discussion

  • Chapter IV: Imaging approach

    • Introduction

    • Materials and methods

      • Methods

        • Step 1: Constructing the patterns

        • Step 2: Ranking the patterns

        • Step 3: Validating the ranking

    • Results

    • Discussion

  • Chapter V: Feasible applications in clinical practice

    • Application 1: Feasibility of monitoring treatment response

      • Introduction

      • Materials and methods

      • Results and discussion

    • Application 2: Correlation between clinical variables and functional imaging

      • Introduction

      • Materials and methods

      • Results and discussion

  • Chapter VI: General discussion and conclusion

    • Summary of discussion

    • Conclusions

  • References

  • Appendices

  • Affidavit

  • Acknowledgments

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Ngày đăng: 11/07/2021, 16:21

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