Use “in spite of” before a noun phrase or the –ing form of a verb:.. In spite of the fog, the plane took off.[r]
(1)Use “despite” before a noun phrase or the –ing form of a verb:
Despite the fog, the plane took off
Despite being foggy, the plane took off
Use “in spite of” before a noun phrase or the –ing form of a verb:
In spite of the fog, the plane took off
In spite of being foggy the plane took off
Use “although” with a clause ( subject+ verb): Although it was foggy, the plane took off
Although he was clever, he failed the exam because he hadn´t studied hard enough