2010 2011 2012 2013 2014 2015. Year[r]
(1)Khac‐DungpNguyena3b3pLeilapChebanea3pHoang‐AnhpNguyenb3pJean‐LouispMontastruca3pHalehpBagheria apLaboratoire1de1Pharmacologie1Médicale1et1/linique(1–quipe1de1Pharmacoépidémiologie1de1lHUMR1INS–RM1wk.W(1Xaculté1de1Médecine1
de1lHUniversité1Paul‐Sabatier(1/entre1Hospitalier1Universitaire(1/entre1Midi‐Pyrénées1de1PharmacoVigilance(1de1Pharmacoépidémiologie1 et1dHInformation1sur1le1Médicament1de1lHUMR1INS–RM1wk.WToulouse(1yXranceV1bpThe1National1/entre1of16rug1Information1and1]dverse1 6rug1Reaction1Monitoring(1Hanoi1University1of1Pharmacy(1Hanoi1yVietnamV
Method
Introduction
Socialpharmacology
Results
6rug‐induced1anaphylactic1
reactions1is1an1acute1severe1and1
life‐threatening1]dverse16rug1
Reaction1y]6RV1and1the1risk1 differs1between1populationsD1
The1understanding1in1the1
developing1countries1and1the1
influences1of1resource‐limited1
seting1on1the1incidence1of1drug‐1
induced1anaphylaxis1still1remains1 limitedD
cefoperazon
rif
ampicinOisoniazidOp
yr
azinamid
dihydroartemisininOpiperaquin gentamicin
metronidazol
paracetamol
ethambutol
diclof
enac rifampicinclindamycin
rif
ampicinOisoniazidOp
yr
azinamidOethamb
utol
vancomycin
streptomycin
primaquin
iobitridol
isoniazid
pyr
azinamid
haloper
idol
levofloxacinampicillin
ampicilinOsulbactam
amoxicilinOacid3clavulanic
cefotaxim
amoxicillin
cefalexin
ceftriaxon
sulfamethoxazolOtrimethoprim
cefuro
xim
ciproflo
xacin
ceftazidim
The1National1Pharmacovigilance1/enter1created1in1.kkJ1and1 w1Regional1Pharmacovigilance1/enter1created1in1.kww1
manage1the1Pharmacovigilance1activities1in1Vietnam
In1Xrance(1Xrench1Pharmacovigilance1system1contains1xw1 Regional1Pharmacovigilance1/enters1which1collect1and1 mange1the1]6R1reporting1with1the11first1establishment1in1 wJWxD11
Demographicpcharacteristics
0 10 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90 95
150 100 50 50 100 150 200
Age
sex
Female Male
France Vietnam
SuspectedpdrugspinpFrenchpdata
Seting
Main1features1of1the1cases1of1drug‐induced1anaphylaxis1in1
Vietnam1and1Xrench1database1were1separately1described1 and1the1comparisons1of1gender(1age1between1.1groups1
were1analyzed1by1the1Mann‐Whitney1U1nonparametric1
test1for1ordinal1variables1and1the1Xisher’s1exact1test1or1the1
chi‐squared1test1for1categorical1variablesD1
Statisticalpanalysisp
b8v8oh56d8kmn JvbD Mv3A b583ohk9d89mn
34bohbvd7kmn JvbC NvbA b549ohk9dk5mn
b74oh5d47mn JvbM JvbC 995ohb8d79mn
b5boh4d75mn Vv8A LvbX 583ohbbdvbmn
bk4oh3d9mn MvbA JvbD 476oh8d99mn
bb5oh3d6bmn NvkB Vv8A 4v9oh7d7kmn
76ohkd39mn JvbG NvkB b7koh3dk5mn
7bohkdk3mn AvkB MvbA b53ohkd89mn
7vohkdkmn Jv4A HvkA b36ohkd57mn
66ohkdv7mn NvbB Nv5C b33ohkd5bmn
63ohbd98mn JvbX NvbB bk5ohkd36mn
58ohbd8kmn Bv5C LvbC bkkohkd3mn
57ohbd79mn NvbA Vv8C bv9ohkdv6mn
53ohbd67mn Bv5X Lv4A 97ohbd83mn
46ohbd45mn JvbE AvkB 95ohbd79mn
France Vietnam
cefotaxime 6k7ohb9d7mn suxamethonium bvvkohb8d9kmn
ceftriaxone 33kohbvd43mn propofol 67kohbkd69mn
ceftazidime k94oh9dk4mn sufentanil 497oh9d38mn
ciprofloxacine bv4oh3dk7mn amoxicilline 483oh9dbkmn
cefoperazone 98oh3dv8mn amoxiciline/
acidoclavulanic 453oh8d55mn
cefuroxime 87ohkd73mn atracurium k4boh4d55mn
cefalexine 83ohkd6bmn cefazoline kb4oh4dv4mn
paracetamol 8kohkd58mn cetuximab b89oh3d57mn
diclofenac 7kohkdk6mn cisatracurium b54ohkd9bmn
amoxiciline/
acidoclavulanic 63ohbd98mn iomeprol b5bohkd85mn
iobitridol 54ohbd7mn rocuronium b49ohkd8bmn
amoxicilline 48ohbd5bmn oxaliplatine b39ohkd6kmn
levofloxacine 48ohbd5bmn midazolam bk9ohkd44mn
iopromid 43ohbd35mn ketamine bb4ohkdb5mn
amoxicilin 4kohbd3kmn ceftriaxone bbkohkdbbmn
cefoperazon/
sulbactam 4bohbdk9mn carboplatine bv7ohkdvkmn
diclofenac 4bohbdk9mn paracetamol bv7ohkdvkmn
ampicilline 39ohbdk3mn remifentanil bv4ohbd96mn
bupivacain 39ohbdk3mn paclitaxel 89ohbd68mn
cefepime 39ohbdk3mn cefuroxime 68ohbdk8mn
Vietnam France
Spontaneous1]6R1reports1from1January1.kwk1to1
6ecember1.kw31were1collected1for1retrospective1analysis51 in1XPV6(1all1]6Rs1containing1High1Level1Term1
“Anaphylactic and anaphylactoid reactions”1were1 selected:1in1VPV6(1all1]6Rs1meeting1the1anaphylaxis1
definition1by1the1Second1Symposiumw1on1the16efinition1
and1Management1of1]naphylaxis1were1selectedD1
6emographic1data(1suspected1drugs1according1to1 ]natomical1Therapeutic1/hemical1classification1were1 comparedD
Selectionpcriteria
739 769 1027 958 859 935
0 10000 20000 30000 40000
03ppm 253ppm 503ppm 753ppm
2010 2012 2014
Year
Numbe
r3of3anaphyl
axis3repo
rtOyear
Mortal
ity3rate3in3Fra
nce3popul
ation
Statistics1calculation1was1done1by1Software1R
1yversion1xD9Dk(1issued1.w1]pril1.kwWV
AgepandpSexpdistributionpofpdrug‐
inducedpanaphylaxis
SuspectedpdrugspinpVietnamesepdata
ComparisionpofpPharmacologicalpgroups
References
[w]1Sampson1H]1et1alD1Second1symposium1on1the1definition1and1management1of1 anaphylaxis51Summary1report—Second1National1Institute1of1]llergy1and1Infectious1 6iseaseAXood1]llergy1and1]naphylaxis1Network1symposiumD1JD1]llergy1/linD1ImmunolD1 y.kkzV1wwWy.V1xJw–xJWD
Conlusion
‐1These1data1show1some1differences1for1the1characteristics1of1drug‐induced1anaphylaxis1
cases1between1Xrance1and1VietnamD
‐1The1discrepancy1of1drug‐induced1anaphylaxis1between1.1countries1could1be1explained1by1
the1antibiotic1overuse1in1VietnamD
‐1The1further1analysis1is1required1to1fully1discuss1on1social1pharmacology1aspectsD
iobitr
idol
remif
entanil
paclitaxel
oxaliplatine
atracurium
association
suf
entanil
cefuroxime
amoxicilline
infliximab
ketamine
ceftr
iaxone
amoxicillineclavulanic
lidocaine
methylprednisolone
vancomycine
cefazoline
suxamethonium
ketoprofene
cetuximab
carboplatine
rocuronium
acide
par
acetamol
iomeprol
etomidate
propof
ol
cisatr
acur
ium
brom
ure
midazolam
250 500 750 1000
2010 2011 2012 2013 2014 2015
Year
Number3of3ADR3repor
ts AntibioticsMinduced3anaphylaxis
Total3drugsMinduced3anaphylaxis
Topp2:ppofpdrugs‐inducedpanaphylaxispinp2pcountries
J:1D1/ephalosporins1and1carbapenems:1J:1C1Penicillins:1J:1M1quinolones:1V:8Ap
iodinated1X‐ray1contrast1media
M:3A1Muscle1relaxants:1N:1A1general1anesthetics1LkwX1other1antineoplastic1 agents
Numberpofpdrug‐inducedpanaphylaxispinvolvingp antibioticspcomparedptoptotalpdrugspinpVietnampp Objectivep:p/ompare1the1characteristics1of1the1
drug‐induced1anaphylaxis1between1Xrench1
pharmacovigilance1database1yXPV6V1and1 Vietnamese1pharmacovigilance1database1 yVPV6VD
FRANCE
161 231 330 580
856 1024
0 2000 4000 6000 8000
03ppm 53ppm 103ppm 153ppm
2010 2012 2014
Year
Numbe
r3of3anaphyl
axis3repo
rtOyear
Mortal
ity3rate3in3Vie
tnamese3po
pulation
Other3ADR Anaphylaxis