Circulating tumour cells (CTC) are receiving increasing attention as prognostic, predictive and pharmacodynamic biomarkers in cancer patients. However, their clinical significance can be dependent on an accurate determination of CTC around cut-off values at low cell counts (
Cummings et al BMC Cancer 2013, 13:415 http://www.biomedcentral.com/1471-2407/13/415 TECHNICAL ADVANCE Open Access Method validation of circulating tumour cell enumeration at low cell counts Jeffrey Cummings*†, Karen Morris†, Cong Zhou†, Robert Sloane, Matt Lancashire, Daniel Morris, Stephen Bramley, Matt Krebs, Leila Khoja and Caroline Dive Abstract Background: Circulating tumour cells (CTC) are receiving increasing attention as prognostic, predictive and pharmacodynamic biomarkers in cancer patients However, their clinical significance can be dependent on an accurate determination of CTC around cut-off values at low cell counts (