Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a multifunctional Ig-like cell adhesion molecule that has a wide range of biological functions. According to previous reports, serum CEACAM1 is dysregulated in different malignant tumours and associated with tumour progression.
Zhou et al BMC Cancer 2013, 13:359 http://www.biomedcentral.com/1471-2407/13/359 RESEARCH ARTICLE Open Access Clinical and experimental studies regarding the expression and diagnostic value of carcinoembryonic antigen-related cell adhesion molecule in non-small-cell lung cancer Mu-qing Zhou1†, Yan Du1†, Yi-wen Liu2, Ying-zhi Wang1, Yi-qing He2, Cui-xia Yang2, Wen-juan Wang1 and Feng Gao1,2* Abstract Background: Carcinoembryonic antigen-related cell adhesion molecule (CEACAM1) is a multifunctional Ig-like cell adhesion molecule that has a wide range of biological functions According to previous reports, serum CEACAM1 is dysregulated in different malignant tumours and associated with tumour progression However, the serum CEACAM1 expression in non-small-cell lung carcinomas (NSCLC) is unclear The different expression ratio of CEACAM1-S and CEACAM1-L isoform has seldom been investigated in NSCLC This research is intended to study the serum CEACAM1 and the ratio of CEACAM1-S/L isoforms in NSCLC Methods: The expression of the serum CEACAM1 was determined by enzyme-linked immunosorbent assay The protein expression and the location of CEACAM1 in tumours were observed by immunohistochemical staining The CEACAM1 mRNA levels in tumour and normal adjacent tissues were measured using quantitative real-time PCR, and the expression patterns and the rate of CEACAM1-S and CEACAM1-L were analysed by reverse transcription-PCR Results: Serum CEACAM1 levels were significantly higher in NSCLC patients compared with that from normal healthy controls (P 0.05), the CEACAM1-S and the CEACAM1-S/L (S: L) ratios were significantly higher in tumour than normal tissues (P