Optical imaging of tumor vascularity associated with proliferation and glucose metabolism in early breast cancer: Clinical application of total hemoglobin measurements in the

Near-infrared optical imaging targeting the intrinsic contrast of tissue hemoglobin has emerged as a promising approach for visualization of vascularity in cancer research. We evaluated the usefulness of diffuse optical spectroscopy using time-resolved spectroscopic (TRS) measurements for functional imaging of primary breast cancer.

Ueda et al BMC Cancer 2013, 13:514 http://www.biomedcentral.com/1471-2407/13/514 RESEARCH ARTICLE Open Access Optical imaging of tumor vascularity associated with proliferation and glucose metabolism in early breast cancer: clinical application of total hemoglobin measurements in the breast Shigeto Ueda1, Noriko Nakamiya1, Kazuo Matsuura1, Takashi Shigekawa1, Hiroshi Sano1, Eiko Hirokawa1, Hiroko Shimada1, Hiroaki Suzuki4, Motoki Oda4, Yutaka Yamashita4, Osamu Kishino3, Ichiei Kuji2, Akihiko Osaki1 and Toshiaki Saeki1* Abstract Background: Near-infrared optical imaging targeting the intrinsic contrast of tissue hemoglobin has emerged as a promising approach for visualization of vascularity in cancer research We evaluated the usefulness of diffuse optical spectroscopy using time-resolved spectroscopic (TRS) measurements for functional imaging of primary breast cancer Methods: Fifty-five consecutive TNM stageI/II patients with histologically proven invasive ductal carcinoma and operable breast tumors (