Zoledronic acid inhibits pulmonary metastasis dissemination in a preclinical model of Ewing’s sarcoma via inhibition of cell migration

Ewing’s sarcoma (ES) is the second most frequent primitive malignant bone tumor in adolescents with a very poor prognosis for high risk patients, mainly when lung metastases are detected (overall survival

Odri et al BMC Cancer 2014, 14:169 http://www.biomedcentral.com/1471-2407/14/169 RESEARCH ARTICLE Open Access Zoledronic acid inhibits pulmonary metastasis dissemination in a preclinical model of Ewing’s sarcoma via inhibition of cell migration Guillaume Odri1,2,3, Pui-Pui Kim1,2, Franỗois Lamoureux1,2, Cộline Charrier1,2, Sộverine Battaglia1,2, Jộrụme Amiaud1,2, Dominique Heymann1,2, Franỗois Gouin1,2,3 and Franỗoise Redini1,2,4* Abstract Background: Ewing’s sarcoma (ES) is the second most frequent primitive malignant bone tumor in adolescents with a very poor prognosis for high risk patients, mainly when lung metastases are detected (overall survival