Fundamental etiologic differences have been suggested to cause earlier onset of breast cancer in less developed countries (LDCs) than in more developed countries (MDCs). We explored this hypothesis using world-wide breast cancer incidence data.
Ghiasvand et al BMC Cancer 2014, 14:343 http://www.biomedcentral.com/1471-2407/14/343 RESEARCH ARTICLE Open Access Higher incidence of premenopausal breast cancer in less developed countries; myth or truth? Reza Ghiasvand1,2, Hans-Olov Adami3,4, Iraj Harirchi1, Rahim Akrami5,1 and Kazem Zendehdel1,4* Abstract Background: Fundamental etiologic differences have been suggested to cause earlier onset of breast cancer in less developed countries (LDCs) than in more developed countries (MDCs) We explored this hypothesis using world-wide breast cancer incidence data Methods: We compared international age-standardized incidence rates (ASR) of pre- (