The existence of two distinct groups of tumors with different clinical characteristic is a remarkable feature of transitional cell carcinomas (TCCs) of the bladder. More than 70% are low-grade (LG) non-infiltrating (NI) cancers at diagnosis, but 60-80% of them recur at least one time and 10-20% progress in stage and grade.
Conconi et al BMC Cancer 2014, 14:646 http://www.biomedcentral.com/1471-2407/14/646 RESEARCH ARTICLE Open Access Chromosomal imbalances in human bladder urothelial carcinoma: similarities and differences between biopsy samples and cancer stem-like cells Donatella Conconi1†, Elena Panzeri1†, Serena Redaelli1, Giorgio Bovo2, Paolo Viganò3, Guido Strada3, Leda Dalprà1 and Angela Bentivegna1* Abstract Background: The existence of two distinct groups of tumors with different clinical characteristic is a remarkable feature of transitional cell carcinomas (TCCs) of the bladder More than 70% are low-grade (LG) non-infiltrating (NI) cancers at diagnosis, but 60-80% of them recur at least one time and 10-20% progress in stage and grade On the other hand, about 20% of tumors show muscle invasion (IN) and have a poor prognosis with