Evaluation of CD4 Cell count and its associating factors - In HIV-TB Co-infection

HIV/AIDS is a serious life threatening disease. The interaction of TB & HIV is two-fold, with TB being the leading cause of death among HIV infected patients. A decrease in CD4 count in HIV-TB co-infection, leads to an increase in morbidity and mortality. So this study was done to evaluate the CD4 cell count and its associating factors in HIV-TB co infection to estimate their immune status.

Int.J.Curr.Microbiol.App.Sci (2017) 6(5): 747-752 International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume Number (2017) pp 747-752 Journal homepage: http://www.ijcmas.com Original Research Article https://doi.org/10.20546/ijcmas.2017.605.084 Evaluation of CD4 Cell Count and its Associating Factors - In HIV-TB Co-Infection Jyotsna Chandwani*, Priyanka Soni, Geeta Parihar and Chandrakant Meena Department of Microbiology, JLN Medical College and Hospital, Ajmer, India *Corresponding author: ABSTRACT Keywords CD4 count, extra-pulmonary TB, pulmonary TB, HIV Article Info Accepted: 04 April 2017 Available Online: 10 May 2017 HIV/AIDS is a serious life threatening disease The interaction of TB & HIV is two-fold, with TB being the leading cause of death among HIV infected patients A decrease in CD4 count in HIV-TB co-infection, leads to an increase in morbidity and mortality So this study was done to evaluate the CD4 cell count and its associating factors in HIV-TB co infection to estimate their immune status This was a retrospective study, conducted in Jawahar Lal Nehru Medical College & associated group of Hospitals, Ajmer, Rajasthan, India A total of 289 HIV-TB co- infected patients attending ART centre, from January 2015 to December 2016 were enrolled in this study CD4 count was done by BD FACS count Statistical analysis was performed with the SPSS A total of 289 HIV/AIDS seropositive cases on ART having co-infection of TB were included in the study In our study EPTB patients160 (55.36%) were higher in number as compared to PTB patients106 (44.64%) In majority of cases CD4 count was 40 year 103(35.64%) Our finding were similar to Siddeswari et al., (2016) in which there were 37.50% cases, whereas Mihir Bhattacharya et al., (2011) reported slightly higher number of cases in which there were 45% cases affected in the same age group This may be due to the fact, that, as the age progresses the immunity decreases (Mihir et al., 2011; Siddeswari et al., 2016) In this study males were affected more than females which was 223(77.16%) Ketki Jangid et al., (2015) & Amara Ezeamama et al., (2015) also reported males to be in higher number which were 81.25% & 57% respectively This may be because of the reason that the male has to migrate for occupation and stay away from spouse for a longer period In our result we observed a higher number of patients whose had CD4 cell count