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Chronic kidney disease and the risk of cancer: An individual patient data meta-analysis of 32,057 participants from six prospective studies

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Chronic kidney disease (CKD) is an established risk factor for cardiovascular disease but the relevance of reduced kidney function to cancer risk is uncertain. Individual patient data were collected from six studies (32,057 participants); including one population-based cohort and five randomized controlled trials.

Wong et al BMC Cancer (2016) 16:488 DOI 10.1186/s12885-016-2532-6 RESEARCH ARTICLE Open Access Chronic kidney disease and the risk of cancer: an individual patient data meta-analysis of 32,057 participants from six prospective studies Germaine Wong1,2*†, Natalie Staplin3†, Jonathan Emberson3, Colin Baigent3,4, Robin Turner5, John Chalmers6, Sophia Zoungas6,7, Carol Pollock8, Bruce Cooper8, David Harris2, Jie Jin Wang9, Paul Mitchell9, Richard Prince10, Wai Hon Lim10, Joshua Lewis10, Jeremy Chapman2 and Jonathan Craig1 Abstract Background: Chronic kidney disease (CKD) is an established risk factor for cardiovascular disease but the relevance of reduced kidney function to cancer risk is uncertain Methods: Individual patient data were collected from six studies (32,057 participants); including one population-based cohort and five randomized controlled trials Participants were grouped into one of five CKD categories (estimated glomerular filtration rate [eGFR] ≥75 mL/min/1.73 m2; eGFR ≥60 to

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