KDIGO 2013 lipids guideline english

Official Journal of the International Society of Nephrology KDIGO Clinical Practice Guideline for Lipid Management in Chronic Kidney Disease volume | issue | november 2013 http://www.kidney-international.org KDIGO Clinical Practice Guideline for Lipid Management in Chronic Kidney Disease KDIGO gratefully acknowledges the founding sponsor, National Kidney Foundation, and the following consortium of sponsors that make our initiatives possible: Abbott, Amgen, Bayer Schering Pharma, Belo Foundation, Bristol-Myers Squibb, Chugai Pharmaceutical, Coca-Cola Company, Dole Food Company, Fresenius Medical Care, Genzyme, Hoffmann-LaRoche, International Society of Nephrology, JC Penney, Kyowa Hakko Kirin, NATCO—The Organization for Transplant Professionals, National Kidney Foundation (NKF)-Board of Directors, Novartis, Pharmacosmos, PUMC Pharmaceutical, Robert and Jane Cizik Foundation, Shire, Takeda Pharmaceutical, Transwestern Commercial Services, Vifor Pharma, and Wyeth Sponsorship Statement: KDIGO is supported by a consortium of sponsors and no funding is accepted for the development of specific guidelines contents http://www.kidney-international.org & 2013 KDIGO VOL | ISSUE | NOVEMBER 2013 KDIGO Clinical Practice Guideline for Lipid Management in Chronic Kidney Disease v Tables and Figures vi KDIGO Board Members vii Reference Keys viiii CKD Nomenclature ix Conversion Factors x Abbreviations and Acronyms 259 Notice 260 Foreword 261 Work Group Membership 262 Abstract 263 Summary of Recommendation Statements 266 Introduction: 268 Chapter 1: Assessment of lipid status in adults with CKD 271 Chapter 2: Pharmacological cholesterol-lowering treatment in adults 280 Chapter 3: Assessment of lipid status in children with CKD 282 Chapter 4: Pharmacological cholesterol-lowering treatment in children 284 Chapter 5: Triglyceride-lowering treatment in adults 286 Chapter 6: Triglyceride-lowering treatment in children 287 Methods for Guideline Development 297 Biographic and Disclosure Information 302 Acknowledgments 303 References The case for updating and context This journal is a member of, and subscribes to the principles of, the Committee on Publication Ethics (COPE) www.publicationethics.org http://www.kidney-international.org contents & 2013 KDIGO TABLES 269 Table Secondary causes of dyslipidemias 270 Table Examples of situations in which measuring cholesterol level might or might not change the management implied by Recommendation 1.2 272 Table Rate of coronary death or non-fatal MI (by age and eGFR) 274 Table Recommended doses of statins in adults with CKD 281 Table Plasma lipid concentrations for children and adolescents 288 Table Systematic review topics and screening criteria 289 Table Hierarchy of outcomes 289 Table Literature yield for RCTs 290 Table Work products for the guideline 290 Table 10 Classification of study quality 291 Table 11 GRADE system for grading quality of evidence 293 Table 12 Final grade for overall quality of evidence 293 Table 13 Balance of benefits and harms 293 Table 14 KDIGO nomenclature and description for grading recommendations 293 Table 15 Determinants of strength of recommendation 294 Table 16 The Conference on Guideline Standardization (COGS) checklist for reporting clinical practice guidelines FIGURES 272 Figure Adjusted relation between LDL-C and HR of myocardial infarction by eGFR as a continuous variable 273 Figure Future 10-year coronary risk based on various patient characteristics 292 Figure Grading the quality of CKD subgroups of non-CKD trials Additional information in the form of supplementary materials can be found online at http://www.kdigo.org/home/guidelines/lipids Kidney International Supplements (2013) 3, v v http://www.kidney-international.org & 2013 KDIGO KDIGO Board Members Garabed Eknoyan, MD Norbert Lameire, MD, PhD Founding KDIGO Co-Chairs Kai-Uwe Eckardt, MD Immediate Past Co-Chair Bertram L Kasiske, MD KDIGO Co-Chair David C Wheeler, MD, FRCP KDIGO Co-Chair Omar I Abboud, MD, FRCP Sharon Adler, MD, FASN Rajiv Agarwal, MD Sharon P Andreoli, MD Gavin J Becker, MD, FRACP Fred Brown, MBA, FACHE Daniel C Cattran, MD, FRCPC Allan J Collins, MD, FACP Rosanna Coppo, MD Josef Coresh, MD, PhD Ricardo Correa-Rotter, MD Adrian Covic, MD, PhD Jonathan C Craig, MBChB, MM (Clin Epi), DCH, FRACP, PhD Angel LM de Francisco, MD Paul E de Jong, MD, PhD Ana Figueiredo, RN, MSc, PhD Mohammed Benghanem Gharbi, MD Gordon Guyatt, MD, MSc, BSc, FRCPC David Harris, MD Lai Seong Hooi, MD Enyu Imai, MD, PhD Lesley A Inker, MD, MS, FRCP Michel Jadoul, MD Simon Jenkins, MBE, FRCGP Suhnggwon Kim, MD, PhD Martin K Kuhlmann, MD Nathan W Levin, MD, FACP Philip K-T Li, MD, FRCP, FACP Zhi-Hong Liu, MD Pablo Massari, MD Peter A McCullough, MD, MPH, FACC, FACP Rafique Moosa, MD Miguel C Riella, MD Adibul Hasan Rizvi, MBBS, FRCP Bernardo Rodriquez-Iturbe, MD Robert Schrier, MD Justin Silver, MD, PhD Marcello Tonelli, MD, SM, FRCPC Yusuke Tsukamoto, MD Theodor Vogels, MSW Angela Yee-Moon Wang, MD, PhD, FRCP Christoph Wanner, MD Elena Zakharova, MD, PhD NKF-KDIGO GUIDELINE DEVELOPMENT STAFF Kerry Willis, PhD, Senior Vice-President for Scientific Activities Michael Cheung, MA, Guideline Development Director Sean Slifer, BA, Guideline Development Manager vi Kidney International Supplements (2013) 3, vi http://www.kidney-international.org & 2013 KDIGO Reference Keys NOMENCLATURE AND DESCRIPTION FOR RATING GUIDELINE RECOMMENDATIONS Within each recommendation, the strength of recommendation is indicated as Level 1, Level 2, or Not Graded, and the quality of the supporting evidence is shown as A, B, C, or D Implications Grade* Patients Clinicians Policy-makers Level ‘We recommend’ Most people in your situation would want the recommended course of action and only a small proportion would not Most patients should receive the recommended course of action The recommendation can be evaluated as a candidate for developing a policy or a performance measure Level ‘We suggest’ The majority of people in your situation would want the recommended course of action, but many would not Different choices will be appropriate for different patients Each patient needs help to arrive at a management decision consistent with her or his values and preferences The recommendation is likely to require substantial debate and involvement of stakeholders before policy can be determined *The additional category ‘Not Graded’ was used, typically, to provide guidance based on common sense or where the topic does not allow adequate application of evidence The most common examples include recommendations regarding monitoring intervals, counseling, and referral to other clinical specialists The ungraded recommendations are generally written as simple declarative statements, but are not meant to be interpreted as being stronger recommendations than Level or recommendations Grade Quality of evidence Meaning A B C D High Moderate Low Very low We are confident that the true effect lies close to that of the estimate of the effect The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different The true effect may be substantially different from the estimate of the effect The estimate of effect is very uncertain, and often will be far from the truth Kidney International Supplements (2013) 3, vii vii http://www.kidney-international.org & 2013 KDIGO CURRENT CHRONIC KIDNEY DISEASE (CKD) NOMENCLATURE USED BY KDIGO CKD is defined as abnormalities of kidney structure or function, present for 43 months, with implications for health CKD is classified based on Cause, GFR category (G1-G5), and Albuminuria category (A1-A3), abbreviated as CGA Prognosis of CKD by GFR and albuminuria category Persistent albuminuria categories Description and range GFR categories (ml/min/ 1.73 m2) Description and range Prognosis of CKD by GFR and Albuminuria Categories: KDIGO 2012 A1 A2 A3 Normal to mildly increased Moderately increased Severely increased 30 mg/mmol ≥90 G1 Normal or high G2 Mildly decreased 60-89 G3a Mildly to moderately decreased 45-59 G3b Moderately to severely decreased 30-44 G4 Severely decreased 15-29 G5 Kidney failure