e1 References 1 Lynch JK, Hirtz DG, DeVeber G, Nelson KB Report of the Na tional Institute of Neurological Disorders and Stroke workshop on perinatal and childhood stroke Pediatrics 2002;109(1) 116 12[.]
e1 References Lynch JK, Hirtz DG, DeVeber G, Nelson KB Report of the National Institute of Neurological Disorders and Stroke workshop on perinatal and childhood stroke Pediatrics 2002;109(1):116-123 Fullerton HJ, Chetkovich DM, Wu YW, Smith WS, Johnston SC Deaths from stroke in US children, 1979 to 1998 Neurology 2002; 59(1):34-39 Fullerton HJ, Wu YW, Sidney S, Johnston SC Risk of recurrent childhood arterial ischemic stroke in a population-based cohort: the importance of cerebrovascular imaging Pediatrics 2007;119(3): 495-501 Mackay MT, Wiznitzer M, Benedict SL, et al Arterial ischemic stroke risk factors: the International Pediatric Stroke Study Ann Neurol 2011;69(1):130-140 Wintermark M, Hills NK, deVeber GA, et al Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the vascular effects of infection in pediatric stroke study Stroke 2014;45(12):3597-3605 Ganesan V, Prengler M, McShane MA, Wade AM, Kirkham FJ Investigation of risk factors in children with arterial ischemic stroke Ann Neurol 2003;53(2):167-173 Amlie-Lefond C, Bernard TJ, Sebire G, et al Predictors of cerebral arteriopathy in children with arterial ischemic stroke: results of the International Pediatric Stroke Study Circulation 2009;119(10): 1417-1423 Chabrier S, Rodesch G, Lasjaunias P, Tardieu M, Landrieu P, Sebire G Transient cerebral arteriopathy: a disorder recognized by serial angiograms in children with stroke J Child Neurol 1998;13(1):27-32 Askalan R, Laughlin S, Mayank S, et al Chickenpox and stroke in childhood: a study of frequency and causation Stroke 2001;32(6): 1257-1262 10 Duan L, Bao XY, Yang WZ, et al Moyamoya disease in China: its clinical features and outcomes Stroke 2012;43(1):56-60 11 Fukui M Current state of study on moyamoya disease in Japan Surg Neurol 1997;47(2):138-143 12 Rafay MF, Armstrong D, Deveber G, Domi T, Chan A, MacGregor DL Craniocervical arterial dissection in children: clinical and radiographic presentation and outcome J Child Neurol 2006;21(1):8-16 13 Monagle P, Chan AK, Goldenberg NA, et al Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Chest 2012;141(suppl 2): e737S-e801S 14 Kernan WN, Ovbiagele B, Black HR, et al Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association Stroke 2014;45(7): 2160-2236 15 Vanakker OM, Hemelsoet D, De Paepe A Hereditary connective tissue diseases in young adult stroke: a comprehensive synthesis Stroke Res Treat 2011;2011:712903 16 Moharir M, Shroff M, Benseler SM Childhood central nervous system vasculitis Neuroimaging Clin N Am 2013;23(2):293-308 17 Benseler S, Pohl D Childhood central nervous system vasculitis Handb Clin Neurol 2013;112:1065-1078 18 Boelman C, Shroff M, Yau I, et al Antithrombotic therapy for secondary stroke prevention in bacterial meningitis in children J Pediatr 2014;165(4):799-806 19 Lanthier S, Armstrong D, Domi T, deVeber G Post-varicella arteriopathy of childhood: natural history of vascular stenosis Neurology 2005;64(4):660-663 20 Nagel MA, Cohrs RJ, Mahalingam R, et al The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features Neurology 2008;70(11):853-860 21 Sebire G, Meyer L, Chabrier S Varicella as a risk factor for cerebral infarction in childhood: a case-control study Ann Neurol 1999;45(5):679-680 22 Gilden DH, Kleinschmidt-DeMasters BK, LaGuardia JJ, Mahalingam R, Cohrs RJ Neurologic complications of the reactivation of varicella-zoster virus N Engl J Med 2000;342(9):635-645 23 Ohene-Frempong K, Weiner SJ, Sleeper LA, et al Cerebrovascular accidents in sickle cell disease: rates and risk factors Blood 1998; 91(1):288-294 24 Adams RJ, McKie VC, Hsu L, et al Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography N Engl J Med 1998; 339(1):5-11 25 Lee MT, Piomelli S, Granger S, et al Stroke Prevention Trial in Sickle Cell Anemia (STOP): extended follow-up and final results Blood 2006;108(3):847-852 26 Bishop S, Matheus MG, Abboud MR, et al Effect of chronic transfusion therapy on progression of neurovascular pathology in pediatric patients with sickle cell anemia Blood Cells Mol Dis 2011; 47(2):125-128 27 Dobson SR, Holden KR, Nietert PJ, et al Moyamoya syndrome in childhood sickle cell disease: a predictive factor for recurrent cerebrovascular events Blood 2002;99(9):3144-3150 28 Hulbert ML, McKinstry RC, Lacey JL, et al Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease Blood 2011;117(3):772-779 29 Prengler M, Pavlakis SG, Prohovnik I, Adams RJ Sickle cell disease: the neurological complications Ann Neurol 2002;51(5):543-552 30 Miller ST, Macklin EA, Pegelow CH, et al Silent infarction as a risk factor for overt stroke in children with sickle cell anemia: a report from the Cooperative Study of Sickle Cell Disease J Pediatr 2001;139(3):385-390 31 Yawn BP, Buchanan GR, Afenyi-Annan AN, et al Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members JAMA 2014;312(10):1033-1048 32 Adams RJ, Cox M, Ozark SD, et al Coexistent sickle cell disease has no impact on the safety or outcome of lytic therapy in acute ischemic stroke: findings from get with the guidelines-stroke Stroke 2017;48(3):686-691 33 Strater R, Vielhaber H, Kassenbohmer R, von Kries R, Gobel U, Nowak-Gottl U Genetic risk factors of thrombophilia in ischaemic childhood stroke of cardiac origin A prospective ESPED survey Eur J Pediatr 1999;158(suppl 3):S122-S125 34 Rodan L, McCrindle BW, Manlhiot C, et al Stroke recurrence in children with congenital heart disease Ann Neurol 2012;72(1): 103-111 35 Kenet G, Sadetzki S, Murad H, et al Factor V Leiden and antiphospholipid antibodies are significant risk factors for ischemic stroke in children Stroke 2000;31(6):1283-1288 36 Rivkin MJ, deVeber G, Ichord RN, et al Thrombolysis in pediatric stroke study Stroke 2015;46(3):880-885 37 Shellhaas RA, Smith SE, O’Tool E, Licht DJ, Ichord RN Mimics of childhood stroke: characteristics of a prospective cohort Pediatrics 2006;118(2):704-709 38 Ichord RN, Bastian R, Abraham L, et al Interrater reliability of the Pediatric National Institutes of Health Stroke Scale (PedNIHSS) in a multicenter study Stroke 2011;42(3):613-617 39 Srinivasan J, Miller SP, Phan TG, Mackay MT Delayed recognition of initial stroke in children: need for increased awareness Pediatrics 2009;124(2):e227-e234 40 Danchaivijitr N, Cox TC, Saunders DE, Ganesan V Evolution of cerebral arteriopathies in childhood arterial ischemic stroke Ann Neurol 2006;59(4):620-626 41 Buerki S, Roellin K, Remonda L, et al Neuroimaging in childhood arterial ischaemic stroke: evaluation of imaging modalities and aetiologies Dev Med Child Neurol 2010;52(11):1033-1037 42 Husson B, Lasjaunias P Radiological approach to disorders of arterial brain vessels associated with childhood arterial stroke-a comparison between MRA and contrast angiography Pediatr Radiol 2004;34(1):10-15 e2 43 Burger IM, Murphy KJ, Jordan LC, Tamargo RJ, Gailloud P Safety of cerebral digital subtraction angiography in children: complication rate analysis in 241 consecutive diagnostic angiograms Stroke 2006;37(10):2535-2539 44 Ferriero DM, Fullerton HJ, Bernard TJ, et al Management of stroke in neonates and children: a scientific statement from the American Heart Association/American Stroke Association Stroke 2019;50(3): e51-e96 45 Amlie-Lefond C, Shaw DWW, Cooper A, et al Risk of intracranial hemorrhage following intravenous tPA (Tissue-Type Plasminogen Activator) for acute stroke is low in children Stroke 2020;51(2): 542-548 46 Powers WJ, Rabinstein AA, Ackerson T, et al Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: A guideline for healthcare professionals from the American Heart Association/American Stroke Association Stroke 2019;50:e344-e418 47 Albers GW, Marks MP, Kemp S, et al Thrombectomy for stroke at to 16 hours with selection by perfusion imaging N Engl J Med 2018;378(8):708-718 48 Nogueira RG, Jadhav AP, Haussen DC, et al Thrombectomy to 24 hours after stroke with a mismatch between deficit and infarct N Engl J Med 2018;378(1):11-21 49 Warkentin TE, Greinacher A, Koster A, Lincoff AM Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest 2008;133(suppl 6):340S-380S 50 Monagle P, Newall F Anticoagulation in children Thromb Res 2012;130(2):142-146 51 Pinsky PF, Hurwitz ES, Schonberger LB, Gunn WJ Reye’s syndrome and aspirin Evidence for a dose-response effect JAMA 1988;260(5):657-661 52 Wasay M, Dai AI, Ansari M, Shaikh Z, Roach ES Cerebral venous sinus thrombosis in children: a multicenter cohort from the United States J Child Neurol 2008;23(1):26-31 53 deVeber G, Andrew M, Adams C, et al Cerebral sinovenous thrombosis in children N Engl J Med 2001;345(6):417-423 54 Sebire G, Tabarki B, Saunders DE, et al Cerebral venous sinus thrombosis in children: risk factors, presentation, diagnosis and outcome Brain 2005;128(Pt 3):477-489 55 Kenet G, Lutkhoff LK, Albisetti M, et al Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies Circulation 2010;121(16):1838-1847 56 Waugh J, Plumb P, Rollins N, Dowling MM Prolonged direct catheter thrombolysis of cerebral venous sinus thrombosis in children: a case series J Child Neurol 2012;27(3):337-345 57 Santoro N, Colombini A, Silvestri D, et al Screening for coagulopathy and identification of children with acute lymphoblastic leukemia at a higher risk of symptomatic venous thrombosis: an AIEOP experience J Pediatr Hematol Oncol 2013;35(5):348-355 58 Heller C, Heinecke A, Junker R, et al Cerebral venous thrombosis in children: a multifactorial origin Circulation 2003;108(11): 1362-1367 59 Bonduel M, Sciuccati G, Hepner M, Torres AF, Pieroni G, Frontroth JP Prethrombotic disorders in children with arterial ischemic stroke and sinovenous thrombosis Arch Neurol 1999;56(8):967-971 60 Carvalho KS, Bodensteiner JB, Connolly PJ, Garg BP Cerebral venous thrombosis in children J Child Neurol 2001;16(8):574-580 61 Mahadeo KM, Dhall G, Panigrahy A, Lastra C, Ettinger LJ Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year-old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury Pediatr Hematol Oncol 2010;27(1):46-52 62 Buoni S, Molinelli M, Mariottini A, et al Homocystinuria with transverse sinus thrombosis J Child Neurol 2001;16(9):688-690 63 Ross CS, Brown TM, Kotagal S, Rodriguez V Cerebral venous sinus thrombosis in pediatric cancer patients: long-term neurological outcomes J Pediatr Hematol Oncol 2013;35(4):299-302 64 Hedlund GL Cerebral sinovenous thrombosis in pediatric practice Pediatr Radiol 2013;43(2):173-188 65 Stauffer C, Josiah AF, Fortes M, Menaker J, Cole JW Lemierre syndrome secondary to community-acquired methicillin-resistant Staphylococcus aureus infection associated with cavernous sinus thromboses J Emerg Med 2013;44(2):e177-e182 66 Siddiqi SA, Nishat S, Kanwar D, Ali F, Azeemuddin M, Wasay M Cerebral venous sinus thrombosis: association with primary varicella zoster virus infection J Stroke Cerebrovasc Dis 2012;21(8):917.e1-e4 67 Johnson MC, Parkerson N, Ward S, de Alarcon PA Pediatric sinovenous thrombosis J Pediatr Hematol Oncol 2003;25(4):312-315 68 Gokce M, Bilginer Y, Besbas N, et al Hematological features of pediatric systemic lupus erythematosus: suggesting management strategies in children Lupus 2012;21(8):878-884 69 Robison NJ, Dawlabani N, Lastra CR, Dhall G Cerebral sinus thrombosis in a child with active ulcerative colitis and factor V Leiden Pediatr Blood Cancer 2009;52(7):867-869 70 Dogan M, Peker E, Akbayram S, et al Cerebral venous sinus thrombosis in children with celiac disease Clin Appl Thromb Hemost 2011;17(5):466-469 71 van Eimeren VF, Billinghurst L, Askalan R, et al Cerebral sinus venous thrombosis in a child with hyperthyroidism Pediatr Blood Cancer 2012;58(1):107-108 72 Uluduz D, Kurtuncu M, Yapici Z, et al Clinical characteristics of pediatric-onset neuro-Behcet disease Neurology 2011;77(21): 1900-1905 73 Fluss J, Geary D, deVeber G Cerebral sinovenous thrombosis and idiopathic nephrotic syndrome in childhood: report of four new cases and review of the literature Eur J Pediatr 2006;165(10):709-716 74 Finkel L, Piantino J, Goldstein J, Wainwright MS Venous stroke and status epilepticus due to milk-induced anemia in a child Pediatr Emerg Care 2015;31(2):129-131 75 Kurosawa H, Okuya M, Matsushita T, et al JAK2V617F mutationpositive childhood essential thrombocythemia associated with cerebral venous sinus thrombosis J Pediatr Hematol Oncol 2009;31(9):678-680 76 Jensen AW, Tefferi A, Arndt CA Cerebral venous sinus thrombosis associated with essential thrombocytosis in a pediatric patient J Pediatr Hematol Oncol 2007;29(3):156-159 77 Reddingius RE, Patte C, Couanet D, Kalifa C, Lemerle J Dural sinus thrombosis in children with cancer Med Pediatr Oncol 1997;29(4):296-302 78 Ozcan A, Canpolat M, Doganay S, et al Cerebral sinus venous thrombosis and prothrombotic risk factors in children: a singlecenter experience from Turkey J Pediatr Hematol Oncol 2018;40(6): e369-e372 79 Pearson V, Ruzas C, Krebs NF, Goldenberg NA, Manco-Johnson MJ, Bernard TJ Overweight and obesity are increased in childhoodonset cerebrovascular disease J Child Neurol 2013;28(4):517-519 80 Forbes JA, Reig AS, Tomycz LD, Tulipan N Intracranial hypertension caused by a depressed skull fracture resulting in superior sagittal sinus thrombosis in a pediatric patient: treatment with ventriculoperitoneal shunt insertion J Neurosurg Pediatr 2010;6(1):23-28 81 Matsushige T, Nakaoka M, Kiya K, Takeda T, Kurisu K Cerebral sinovenous thrombosis after closed head injury J Trauma 2009;66(6):1599-1604 82 Sellers AR, Nguyen AT, Betensky M, Mills K, Goldenberg NA, Shimony N Risk factors for pediatric cerebral sinovenous thrombosis: a case-control study with pediatric neuroradiologist case validation Blood 2019;134(suppl 1):2427 83 Saposnik G, Barinagarrementeria F, Brown Jr RD, et al Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/ American Stroke Association Stroke 2011;42(4):1158-1192 84 Kenet G, Kirkham F, Niederstadt T, et al Risk factors for recurrent venous thromboembolism in the European collaborative paediatric e3 database on cerebral venous thrombosis: a multicentre cohort study Lancet Neurol 2007;6(7):595-603 85 deVeber G, Chan A, Monagle P, et al Anticoagulation therapy in pediatric patients with sinovenous thrombosis: a cohort study Arch Neurol 1998;55(12):1533-1537 86 Moharir MD, Shroff M, Stephens D, et al Anticoagulants in pediatric cerebral sinovenous thrombosis: a safety and outcome study Ann Neurol 2010;67(5):590-599 87 Monagle P, Chan AKC, Goldenberg NA, et al Antithrombotic therapy in neonates and children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines Chest 2012;141(suppl 2):e737S-e801S 88 Ichord R Cerebral sinovenous thrombosis Front Pediatr 2017;5:163 89 Mallick AA, Sharples PM, Calvert SE, et al Cerebral venous sinus thrombosis: a case series including thrombolysis Arch Dis Child 2009;94(10):790-794 90 Ichord RN, Benedict SL, Chan AK, Kirkham FJ, Nowak-Gottl U, International Paediatric Stroke Study Group Paediatric cerebral sinovenous thrombosis: findings of the International Paediatric Stroke Study Arch Dis Child 2015;100(2):174-179 91 Broderick J, Talbot GT, Prenger E, Leach A, Brott T Stroke in children within a major metropolitan area: the surprising importance of intracerebral hemorrhage J Child Neurol 1993;8(3):250-255 92 Jordan LC, Hillis AE Hemorrhagic stroke in children Pediatr Neurol 2007;36(2):73-80 93 Perkins E, Stephens J, Xiang H, Lo W The cost of pediatric stroke acute care in the United States Stroke 2009;40(8):2820-2827 94 Al-Jarallah A, Al-Rifai MT, Riela AR, Roach ES Nontraumatic brain hemorrhage in children: etiology and presentation J Child Neurol 2000;15(5):284-289 95 Lynch JK, Han CJ Pediatric stroke: what we know and what we need to know? Semin Neurol 2005;25(4):410-423 96 Beslow LA, Licht DJ, Smith SE, et al Predictors of outcome in childhood intracerebral hemorrhage: a prospective consecutive cohort study Stroke 2010;41(2):313-318 97 Riordan CP, Orbach DB, Smith ER, Scott RM Acute fatal hemorrhage from previously undiagnosed cerebral arteriovenous malformations in children: a single-center experience J Neurosurg Pediatr 2018;22(3):244-250 98 Morgan T, McDonald J, Anderson C, et al Intracranial hemorrhage in infants and children with hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome) Pediatrics 2002;109(1):E12 99 Smith ER, Butler WE, Ogilvy CS Surgical approaches to vascular anomalies of the child’s brain Curr Opin Neurol 2002;15(2):165-171 100 Kondziolka D, Humphreys RP, Hoffman HJ, Hendrick EB, Drake JM Arteriovenous malformations of the brain in children: a forty year experience Can J Neurol Sci 1992;19(1):40-45 101 Fullerton HJ, Achrol AS, Johnston SC, et al Long-term hemorrhage risk in children versus adults with brain arteriovenous malformations Stroke 2005;36(10):2099-2104 102 Lang SS, Beslow LA, Bailey RL, et al Follow-up imaging to detect recurrence of surgically treated pediatric arteriovenous malformations J Neurosurg Pediatr 2012;9(5):497-504 103 Langer DJ, Lasner TM, Hurst RW, Flamm ES, Zager EL, King Jr JT Hypertension, small size, and deep venous drainage are associated with risk of hemorrhagic presentation of cerebral arteriovenous malformations Neurosurgery 1998;42(3):481-486; discussion 487-489 104 Spetzler RF, Hargraves RW, McCormick PW, Zabramski JM, Flom RA, Zimmerman RS Relationship of perfusion pressure and size to risk of hemorrhage from arteriovenous malformations J Neurosurg 1992;76(6):918-923 105 Waltimo O The relationship of size, density and localization of intracranial arteriovenous malformations to the type of initial symptom J Neurol Sci 1973;19(1):13-19 106 Niazi TN, Klimo Jr P, Anderson RC, Raffel C Diagnosis and management of arteriovenous malformations in children Neurosurg Clin N Am 2010;21(3):443-456 107 Spetzler RF, Martin NA A proposed grading system for arteriovenous malformations J Neurosurg 1986;65(4):476-483 108 Yamada S, Takagi Y, Nozaki K, Kikuta K, Hashimoto N Risk factors for subsequent hemorrhage in patients with cerebral arteriovenous malformations J Neurosurg 2007;107(5):965-972 109 Gross BA, Storey A, Orbach DB, Scott RM, Smith ER Microsurgical treatment of arteriovenous malformations in pediatric patients: the Boston Children’s Hospital experience J Neurosurg Pediatr 2015;15(1):71-77 110 Nerva JD, Kim LJ, Barber J, et al Outcomes of multimodality therapy in pediatric patients with ruptured and unruptured brain arteriovenous malformations Neurosurgery 2016;78(5):695-707 111 Klimo Jr P, Rao G, Brockmeyer D Pediatric arteriovenous malformations: a 15-year experience with an emphasis on residual and recurrent lesions Childs Nerv Syst 2007;23(1):31-37 112 da Costa L, Wallace MC, Ter Brugge KG, O’Kelly C, Willinsky RA, Tymianski M The natural history and predictive features of hemorrhage from brain arteriovenous malformations Stroke 2009; 40(1):100-105 113 Dinca EB, de Lacy P, Yianni J, et al Gamma knife surgery for pediatric arteriovenous malformations: a 25-year retrospective study J Neurosurg Pediatr 2012;10(5):445-450 114 Sheth SA, Potts MB, Sneed PK, et al Angiographic features help predict outcome after stereotactic radiosurgery for the treatment of pediatric arteriovenous malformations Childs Nerv Syst 2014;30(2):241-247 115 Jordan LC, Johnston SC, Wu YW, Sidney S, Fullerton HJ The importance of cerebral aneurysms in childhood hemorrhagic stroke: a population-based study Stroke 2009;40(2):400-405 116 Orozco M, Trigueros F, Quintana F, Dierssen G Intracranial aneurysms in early childhood Surg Neurol 1978;9(4):247-252 117 Mehrotra A, Nair AP, Das KK, Srivastava A, Sahu RN, Kumar R Clinical and radiological profiles and outcomes in pediatric patients with intracranial aneurysms J Neurosurg Pediatr 2012;10(4):340-346 118 Huang J, McGirt MJ, Gailloud P, Tamargo RJ Intracranial aneurysms in the pediatric population: case series and literature review Surg Neurol 2005;63(5):424-432; discussion 432-433 129 Buis DR, van Ouwerkerk WJ, Takahata H, Vandertop WP Intracranial aneurysms in children under year of age: a systematic review of the literature Childs Nerv Syst 2006;22(11):1395-1409 120 Curtis SL, Bradley M, Wilde P, et al Results of screening for intracranial aneurysms in patients with coarctation of the aorta AJNR Am J Neuroradiol 2012;33(6):1182-1186 121 Connolly HM, Huston J III, Brown Jr RD, Warnes CA, Ammash NM, Tajik AJ Intracranial aneurysms in patients with coarctation of the aorta: a prospective magnetic resonance angiographic study of 100 patients Mayo Clin Proc 2003;78(12):1491-1499 122 Park DH, Kang SH, Lim DJ, et al Multiple intracranial aneurysms with intraventricular hemorrhage in a child with unilateral fibromuscular dysplasia of the renal artery Pediatr Neurosurg 2008;44(6):486-489 123 Nomura S, Yamashita K, Kato S, et al Childhood subarachnoid hemorrhage associated with fibromuscular dysplasia Childs Nerv Syst 2001;17(7):419-422 124 Chu LC, Johnson PT, Dietz HC, et al Vascular complications of Ehlers-Danlos syndrome: CT findings AJR Am J Roentgenol 2012;198(2):482-487 125 van den Berg JS, Hennekam RC, Cruysberg JR, et al Prevalence of symptomatic intracranial aneurysm and ischaemic stroke in pseudoxanthoma elasticum Cerebrovasc Dis 2000;10(4):315-319 126 Byers PH, Belmont J, Black J, et al Diagnosis, natural history, and management in vascular Ehlers-Danlos syndrome Am J Med Genet C Semin Med Genet 2017;175(1):40-47 127 Anderson RC, McDowell MM, Kellner CP, et al Arteriovenous malformation-associated aneurysms in the pediatric population J Neurosurg Pediatr 2012;9(1):11-16 128 Hoffman C, Riina HA, Stieg P, et al Associated aneurysms in pediatric arteriovenous malformations and the implications for treatment Neurosurgery 2011;69(2):315-322 e4 129 Liu AC, Segaren N, Cox TS, et al Is there a role for magnetic resonance imaging in the evaluation of non-traumatic intraparenchymal haemorrhage in children? Pediatr Radiol 2006;36(9):940-946 130 Proust F, Toussaint P, Garnieri J, et al Pediatric cerebral aneurysms J Neurosurg 2001;94(5):733-739 131 Connolly Jr ES, Rabinstein AA, Carhuapoma JR, et al Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/ American Stroke Association Stroke 2012;43(6):1711-1737 132 Gathier CS, van den Bergh WM, van der Jagt M, et al Induced hypertension for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a randomized clinical trial Stroke 2018;49(1):76-83 133 Ohkuma H, Tsurutani H, Suzuki S Incidence and significance of early aneurysmal rebleeding before neurosurgical or neurological management Stroke 2001;32(5):1176-1180 134 Koroknay-Pal P, Niemela M, Lehto H, et al De novo and recurrent aneurysms in pediatric patients with cerebral aneurysms Stroke 2013;44(5):1436-1439 135 Teasdale GM, Wardlaw JM, White PM, et al The familial risk of subarachnoid haemorrhage Brain 2005;128(Pt 7):1677-1685 136 Giroud M, Lemesle M, Madinier G, Manceau E, Osseby GV, Dumas R Stroke in children under 16 years of age Clinical and etiological difference with adults Acta Neurol Scand 1997;96(6):401-406 137 Al-Holou WN, O’Lynnger TM, Pandey AS, et al Natural history and imaging prevalence of cavernous malformations in children and young adults J Neurosurg Pediatr 2012;9(2):198-205 138 Flemming KD, Link MJ, Christianson TJ, Brown Jr RD Prospective hemorrhage risk of intracerebral cavernous malformations Neurology 2012;78(9):632-636 139 Moriarity JL, Clatterbuck RE, Rigamonti D The natural history of cavernous malformations Neurosurg Clin N Am 1999;10(3):411-417 140 Revencu N, Vikkula M Cerebral cavernous malformation: new molecular and clinical insights J Med Genet 2006;43(9):716-721 141 Xia C, Zhang R, Mao Y, Zhou L Pediatric cavernous malformation in the central nervous system: report of 66 cases Pediatr Neurosurg 2009;45(2):105-113 142 Shurtleff H, Warner M, Poliakov A, et al Functional magnetic resonance imaging for presurgical evaluation of very young pediatric patients with epilepsy J Neurosurg Pediatr 2010;5(5):500-506 143 Abla AA, Lekovic GP, Garrett M, et al Cavernous malformations of the brainstem presenting in childhood: surgical experience in 40 patients Neurosurgery 2010;67(6):1589-1598; discussion 1598-1599 144 Lee CC, Wang WH, Yang HC, et al Gamma Knife radiosurgery for cerebral cavernous malformation Sci Rep 2019;9(1):19743 145 McCracken DJ, Willie JT, Fernald BA, et al Magnetic resonance thermometry-guided stereotactic laser ablation of cavernous malformations in drug-resistant epilepsy: imaging and clinical results Oper Neurosurg (Hagerstown) 2016;12(1):39–48 146 Willie JT, Malcolm JG, Stern MA, et al Safety and effectiveness of stereotactic laser ablation for epileptogenic cerebral cavernous malformations Epilepsia 2019;60(2):220-232 147 Schulte R, Jordan LC, Morad A, Naftel RP, Wellons JC III, Sidonio R Rise in late onset vitamin K deficiency bleeding in young infants because of omission or refusal of prophylaxis at birth Pediatr Neurol 2014;50(6):564-568 148 Shearer MJ Vitamin K deficiency bleeding (VKDB) in early infancy Blood Rev 2009;23(2):49-59 149 Blom I, De Schryver EL, Kappelle LJ, Rinkel GJ, JennekensSchinkel A, Peters AC Prognosis of haemorrhagic stroke in childhood: a long-term follow-up study Dev Med Child Neurol 2003; 45(4):233-239 e5 Abstract: Childhood stroke includes arterial ischemic stroke, cerebral sinus venous thrombosis, and intracranial hemorrhage The diagnosis of acute stroke in childhood is often delayed owing to failure to detect neurologic deficit in a child, low clinical suspicion of stroke, frequency of stroke mimics, and delays in diagnostic imaging Compared with adults, the causes of pediatric stroke are much more heterogeneous and often risk factors, rather than definitive causes, are identified Supportive care in an ICU—with careful attention to optimizing cerebral perfusion and oxygenation, decreasing metabolic demands on the brain, and preventing early stroke recurrence—is critical Key words: Arterial ischemic stroke, recanalization therapies, cerebral sinus venous thrombosis, hemorrhagic stroke, arteriovenous malformations ... C, Josiah AF, Fortes M, Menaker J, Cole JW Lemierre syndrome secondary to community-acquired methicillin-resistant Staphylococcus aureus infection associated with cavernous sinus thromboses J... 2011;77(21): 1900-1905 73 Fluss J, Geary D, deVeber G Cerebral sinovenous thrombosis and idiopathic nephrotic syndrome in childhood: report of four new cases and review of the literature Eur... 2015;100(2):174-179 91 Broderick J, Talbot GT, Prenger E, Leach A, Brott T Stroke in children within a major metropolitan area: the surprising importance of intracerebral hemorrhage J Child Neurol