1128 SECTION IX Pediatric Critical Care Hematology and Oncology clinical presentation and the ability to perform evaluations 288 For children, use of the Cornell Assessment of Pediatric Delirium (CAPD[.]
1128 S E C T I O N I X Pediatric Critical Care: Hematology and Oncology clinical presentation and the ability to perform evaluations.288 For children, use of the Cornell Assessment of Pediatric Delirium (CAPD) has been used to assess for ICANS.295,296 Tocilizumab and siltuximab have been used as treatment for more severe disease, especially if a patient develops ICANS in the setting of active CRS If the patient does not have active CRS and develops severe ICANS, high-dose steroids are often employed, especially in the case of associated increased ICP ICANS generally resolves with time and supportive care (i.e., antiepileptic drugs for seizures, airway management, hypertonic fluids for ICP), but there have been cases of fatal cerebral edema, making close monitoring critical.286,288,297 Key References Bafaqih H, Chehab M, Almohaimeed S, et al Pilot trial of a novel two step therapy protocol using nebulized tranexamic acid and recombinant factor VIIa in children with intractable DAH Ann Saudi Med 2015;35(3):231-239 Bajwa RPS, Mahadeo KM, Taragin BH, et al Consensus report by pediatric acute lung injury and sepsis investigators and pediatric bone marrow transplantation consortium joint working committees: Supportive care guidelines for management of veno-occlusive disease in children and adolescents, Part 1: Focus on investigations, prophylaxis, and specific treatment Biol Blood Marrow Transplant 2017;23:18171825 Bergeron A, Chevret S, Granata A, et al Effects of azithromycin on air flow decline-free survival after allogeneic hematopoietic stem cell transplant: the ALLOZITHRO randomized control trial JAMA 2017;318(6):557-566 Chellapandian D, Lehrnbecher T, Phillips B, et al Bronchoalveolar lavage and lung biopsy in patients with cancer and hematopoietic stemcell transplantation recipients: a systematic review and meta-analysis J Clin Oncol 2015;33(5):501-509 D’Souza A, Fretham C Current uses and outcomes of hematopoietic cell transplantation (HCT): CIBMTR Summary Slides 2018 Available at: https://www.cibmtr.org Dandoy CE, Jodele S, Paff Z, et al Team-based approach to identify cardiac toxicity in critically ill hematopoietic stem cell transplant recipients Pediatr Blood Cancer 2017;64(10) Di Nardo M, Locatelli F, Palmer K, et al Extracorporeal membrane oxygenation in pediatric recipients of hematopoietic stem cell transplantation: an updated analysis of the Extracorporeal Life Support Organization experience Intensive Care Med 2014;40(5):754-756 Duncan CN, Lehmann LE, Cheifetz IM, et al Clinical outcomes of children receiving intensive cardiopulmonary support during hematopoietic stem cell transplant Pediatr Crit Care Med 2013;14(3):261267 Jagasia MH, Greinix HT, Arora M, et al National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I The 2014 Diagnosis and Staging Working Group report Biol Blood Marrow Transplant 2015;21(3): 389-401 Jodele S, Dandoy CE, Myers KC, et al New approaches in the diagnosis, pathophysiology, and treatment of pediatric hematopoietic stem cell transplantation-associated thrombotic microangiopathy Transfus Apher Sci 2016;54:181-190 Jodele S, Davies SM, Lane A, et al Diagnostic and risk criteria for HSCT-associated thrombotic microangiopathy: a study in children and young adults Blood 2014;124:645-653 Jodele S, Fukuda T, Vinks A, et al Eculizumab therapy in children with severe hematopoietic stem cell transplantation-associated thrombotic microangiopathy Biol Blood Marrow Transplant 2014;20;518-525 Jodele S, Hirsch R, Laskin B, Davies S, Witte D, Chima R Pulmonary arterial hypertension in pediatric patients with hematopoietic stem cell transplant-associated thrombotic microangiopathy Biol Blood Marrow Transplant 2013;19(2):202-207 Mahadeo KM, Khazal SJ, Abdel-Azim H, et al Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy Nat Rev Clin Oncol 2019;16:45-63 Mahadeo KM, McArthur J, Adams RH, et al Consensus report by pediatric acute lung injury and sepsis investigators and pediatric bone marrow transplantation consortium joint working committees: Supportive care guidelines for management of veno-occlusive disease in children and adolescents, Part 2: Focus on ascites, fluid and electrolytes, renal and transfusion issues Biol Blood Marrow Transplant 2017;23:2023-2033 Ovchinsly N, Frazier W, Auletta JJ, et al Consensus report by pediatric acute lung injury and sepsis investigators and pediatric bone marrow transplantation consortium joint working committees: Supportive care guidelines for management of veno-occlusive disease in children and adolescents, Part 3: Focus on cardiorespiratory dysfunction, infections, liver dysfunction and delirium Biol Blood Marrow Transplant 2018;24:207-218 Rowan CM, McArthur J, Hsing DD, et al Acute respiratory failure in pediatric hematopoietic cell transplantation: a multicenter study Crit Care Med 2018;46(10):e967-974 Sukdolak C, Tischer S, Dieks D, et al CMV-, EBV- and ADV-specific T cell immunity: screening and monitoring of potential third-party donors to improve post-transplantation outcome Biol Blood Marrow Transplant 2013;19(10):1480-1492 Thomas NJ, Spear D, Wasserman E, et al CALIPSO: A randomized controlled trial of calfactant for acute lung injury in pediatric stem cell and oncology patients Biol Blood Marrow Transplant 2018;24(12):2479-2486 Traube C, Silver G, Kearney J, et al Cornell Assessment of Pediatric Delirium: a valid, rapid, observational tool for screening delirium in the PICU Crit Care Med 2014;42:656-663 Yanik GA, Grupp SA, Pulsipher MA, et al TNF-receptor inhibitor therapy for the treatment of children with idiopathic pneumonia syndrome A joint Pediatric Blood and Marrow Transplant Consortium and Children’s Oncology Group Study (ASCT0521) Biol Blood Marrow Transplant 2015;21(1):67-73 Yanik GA, Ho VT, Levine JE, et al The impact of soluble tumor necrosis factor receptor etanercept on the 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