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e2 Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Rec ommendations on red blood cell transfusion for critically ill chil[.]

e2 Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Recommendations on red blood cell transfusion for critically ill children with acute brain injury from the Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI) Pediatr Crit Care Med 2018;19(suppl 9):S133-S136 40 Valentine SL, Bateman ST, Bembea MM, et al Consensus recommendations for red blood cell transfusion practice in critically ill children from the Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI) Pediatr Crit Care Med 2018;19:884-898 41 Zantek ND, Parker RI, Van de Watering L, et al Recommendations for selection and processing of red blood cell components for pediatric patients from the Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI) Pediatr Crit Care Med 2018;19(suppl 9):S163-S169 42 Napolitano LM, Kurek S, Luchette FA, et al Clinical practice guideline: red blood cell transfusion in adult trauma and critical care Crit Care Med 2009;37:3124-3157 43 Holcomb JB, Zarzabal LA, Michalek JE, et al Increased platelet:RBC ratios are associated with improved survival after massive transfusion J Trauma 2011;71(suppl 3):S318-S328 44 Lau W Neonatal and pediatric transfusion In: Canadian Blood Services, ed Clinical guide to transfusion Ottawa: Canadian Blood Services; 2017 Available at: https://professionaleducation.blood.ca/ en/transfusion/clinical-guide/neonatal-and-pediatric-transfusion 45 Hwu RS, Spinella PC, Keller MS, Baker D, Wallendorf M, Leonard JC The effect of massive transfusion protocol implementation on pediatric trauma care Transfusion 2016;56:2712-2719 46 Holst LB, Haase N, Wetterslev J, et al Lower versus higher hemoglobin threshold for transfusion in septic shock N Engl J Med 2014;371:1381-1391 47 Holst LB Benefits and harms of red blood cell transfusions in patients with septic shock in the intensive care unit Dan Med J 2016;63:B5209 48 Karam O, Tucci M, Ducruet T, et al Red blood cell transfusion thresholds in pediatric septic patients Pediatr Crit Care Med 2011;12:512-518 49 Rouette J, Trottier H, Ducruet T, et al Red blood cell transfusion threshold in post-surgical pediatric intensive care patients: a randomized clinical trial Ann Surg 2010;251:421-427 50 Palmieri TL, Caruso DM, Foster KN, et al Effect of blood transfusion on outcome after major burn injury: a multicenter study Crit Care Med 2006;34:1602-1607 51 Hassan NE, DeCou JM, Reischman D, et al RBC transfusions in children requiring intensive care admission after traumatic injury Pediatr Crit Care Med 2014;15:e306-e313 52 Holzer BR, Egger M, Teuscher R, Koch S, Mboya DM, Smith GD Childhood anemia in Africa: To transfuse or not transfuse? Acta Trop 1993;55:47-51 53 National Institute for Health and Care Excellence (NICE) Blood Transfusion (NG24) London: NICE; 2015 54 Carson JL, Guyatt G, Heddle NM, et al Clinical practice guidelines from the AABB: red blood cell transfusion thresholds and storage JAMA 2016;316:2025-2035 55 National Blood Authority Australia The National Blood Authority’s Patient Blood Management Guidelines: Module – Neonatal and Paediatrics Canberra: National Blood Authority Australia; 2016 56 Allen M Lactate and acid base as a hemodynamic monitor and markers of cellular perfusion Pediatr Crit Care Med 2011;12(suppl 4):S43-S49 57 Neunhoeffer F, Hofbeck M, Schuhmann MU, et al Cerebral oxygen metabolism before and after RBC transfusion in infants following major surgical procedures Pediatr Crit Care Med 2018;19: 318-327 58 Sohn CH, Kim YJ, Seo DW, et al Blood lactate concentration and shock index associated with massive transfusion in emergency department patients with primary postpartum haemorrhage Br J Anaesth 2018;121:378-383 59 Zeroual N, Samarani G, Gallais J, et al ScvO2 changes after redblood-cell transfusion for anaemia in cardiothoracic and vascular ICU patients: an observational study Vox Sang 2018;113:136-142 60 Zygun DA, Nortje J, Hutchison PJ, Timofeev I, Menon DK, Gupta AK The effect of red blood cell transfusion on cerebral oxygenation and metabolism after severe traumatic brain injury Crit Care Med 2009;37:1074-1078 61 Riddington C, Wang W Blood transfusion for preventing stroke in people with sickle cell disease (Cochrane Review) Paper presented at: The Cochrane Library; 2002; Oxford 62 Lelubre C, Bouzat P, Crippa IA, Taccone FS Anemia management after acute brain injury Crit Care 2016;20:152 63 Bergamin FS, Almeida JP, Landoni G, et al Liberal versus restrictive transfusion strategy in critically ill oncologic patients: The transfusion requirements in critically ill oncologic patients randomized controlled trial Crit Care Med 2017;45:766-773 64 de Almeida JP, Vincent JL, Galas FR, et al Transfusion requirements in surgical oncology patients: a prospective, randomized controlled trial Anesthesiology 2015;122:29-38 65 Robitaille N, Lacroix J, Alexandrov L, et al Excess of veno-occlusive disease in a randomized clinical trial on a higher trigger for red blood cells transfusion after bone marrow transplantation: A Canadian Blood Marrow Transplant Group Trial Biol Blood Marrow Transplant 2013;19:468-473 66 Stiller B, Lemmer J, Merkle F, et al Consumption of blood products during mechanical circulatory support in children: comparison between ECMO and a pulsatile ventricular assist device Intensive Care Med 2004;30:1814-1820 67 Fiser RT, Irby K, Ward RM, et al RBC transfusion in pediatric patients supported with extracorporeal membrane oxygenation: is there an impact on tissue oxygenation? Pediatr Crit Care Med 2014;15:806-813 68 O’Halloran CP, Alexander PMA, Andren KG, et al RBC exposure in pediatric extracorporeal membrane oxygenation: Epidemiology and factors associated with large blood transfusion volume Pediatr Crit Care Med 2018;19:767-774 69 Bolton DT Hyperkalaemia, donor blood and cardiac arrest associated with ECMO priming Anaesthesia 2000;55:825-826 70 Schwartz SM Tattered and torn: the life of a RBC on the extracorporeal membrane oxygenation circuit Crit Care Med 2014;42: 1314-1315 71 Tremblay-Roy JS, Harrington K, Poirier N, Ducruet T, Lacroix J Red blood cell transfusion in the postoperative care of pediatric cardiac surgery: a survey on stated practice Pediatr Cardiol 2016;37:1266-1273 72 Henling CE, Carmichael MJ, Keats AS, Cooley DA Cardiac operation for congenital heart disease in children of Jehovah’s Witnesses J Thorac Cardiovasc Surg 1985;89:914-920 73 Kawaguchi A, Bergsland J, Subramanian S Total bloodless open heart surgery in the pediatric age group Circulation 1984;70:1-30 74 Willems A, Harrington K, Lacroix J, et al Comparison of two redcell transfusion strategies after pediatric cardiac surgery Crit Care Med 2010;38:649-656 75 de Gast-Bakker DH, de Wilde RBP, Hazekamp MG, et al Safety and effects of two red blood cell transfusion strategies in pediatric cardiac surgery patients; a randomized controlled trial Intensive Care Med 2013;39:2011-2019 76 Cholette JM, Swartz MF, Rubenstein J, et al Outcomes using a conservative versus liberal red blood cell transfusion strategy in infants requiring cardiac operation Ann Thorac Surg 2017;103:206-214 77 Gibson BE, Todd A, Roberts I, et al Transfusion guidelines for neonates and older children Br J Haematol 2004;124:433-453 78 Cholette JM, Rubenstein JS, Alfieris GM, Powers KS, Eaton M, Lerner NB Children with single ventricle physiology not benefit from higher hemoglobin levels following cavopulmonary connection: results of a prospective, randomized controlled trial of a restrictive v liberal red cell transfusion strategy Pediatr Crit Care Med 2011;12:39-45 e3 79 Markowitz MA, Waters JH, Ness PM Patient blood management: a primary theme in transfusion medicine Transfusion 2014;54:2587 80 Whitaker BI, Rajbhandary S, Harris A The 2013 AABB blood collection, utilization, and patient blood management survey report AABB; 2015 81 Waters JH Perioperative Blood Management A Physician’s Handbook Bethesda: AABB; 2006 82 Weldon BC Blood conservation in pediatric anesthesia Anesthesiol Clin North Am 2005;23:347-361 83 Steffen K, Doctor A, Hoerr J, et al Controlling phlebotomy volume diminishes PICU transfusion: Implementation processes and impact Pediatrics 2017;140:e20162480 84 Hobisch-Hagen P, Wiedermann F, Mayr A, et al Blunted erythropoietic response to anemia in multiply traumatized patients Crit Care Med 2001;29:743-747 85 Corwin HL, Gettinger A, Pearl RG, et al Efficacy of recombinant human erythropoietin in critically ill patients JAMA 2002;288: 2827-2835 86 Widness JA, Madan A, Grindeanu LA, Zimmerman MB, Wong DK, Stevenson DK Reduction in red blood cell transfusions among preterm infants: results of a randomized trial with an in-line blood gas and chemistry monitor Pediatrics 2005;115:1299-1306 87 Bierer R, Roohi M, Peceny C, Ohls RK Erythropoietin increases reticulocyte counts and maintains hematocrit in neonates requiring surgery J Pediatr Surg 2009;44:1540-1545 88 Pieracci FM, Stovall RT, Jaouen B, et al A multicenter, randomized clinical trial of IV iron supplementation for anemia of traumatic critical illness Crit Care Med 2014;42:2048-2057 89 Hod EA, Zhang N, Sokol SA, et al Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation Blood 2010;115:4284-4292 90 Jutras C, Sauthier M, Tucci M, et al Incidence of anemia at discharge of 4890 consecutive pediatric intensive care survivors Vox Sang 2018;113(suppl 1):41–42 91 Demaret P, Karam O, Tucci T, et al Anemia at pediatric intensive care unit discharge: prevalence and risk markers Ann Intensive Care 2017;7:107 92 Yakymenko D, Frandsen KB, Christensen IJ, et al Randomised feasibility study of a more liberal haemoglobin trigger for red blood cell transfusion compared to standard practice in anaemic cancer patients treated with chemotherapy Transfus Med 2018;28: 208-215 93 Antonelou MH, Kriebardis AG, Stamoulis KE, EconomouPetersen E, Margaritis LH, Papassideri IS Red blood cell aging markers during storage in citrate-phosphate-dextrose-saline-adenineglucose-mannitol Transfusion 2010;50:376-389 94 McFaul SJ, Corley JB, Mester CW, Nath J Packed blood cells stored in AS-5 become proinflammatory during storage Transfusion 2009;49:1451-1460 95 Paglia G, SigurjÓnsson ÓE, Bordbar A, et al Metabolic fate of adenine in red blood cells during storage in SAGM solution Transfusion 2016;56:2538-2547 96 Baumgartner JM, Silliman CC, Moore EE, Banerjee A, McCarter MD Stored red blood cell transfusion induces regulatory T cells J Am Coll Surg 2009;208:110-119 97 Phelan HA, Sperry JL, Friese RS Leukoreduction before red blood cell transfusion has no impact on mortality in trauma patients J Surg Res 2007;138:32-36 98 Watkins TR, Rubenfeld GD, Martin TR, et al Effects of leukoreduced blood on acute lung injury after trauma: a randomized controlled trial Crit Care Med 2008;36:1493-1499 99 Friese RS, Sperry JL, Phelan HA, Gentilello LM The use of leukoreduced red blood cell products is associated with fewer infectious complications in trauma patients Am J Surg 2008;196:56-61 100 Bilgin YM, van de Watering LM, Versteegh MI, van Oers MH, Brand A Effects of allogeneic leukocytes in blood transfusions during cardiac surgery on inflammatory mediators and postoperative complications Crit Care Med 2010;38:546-552 101 Hebert PC, Fergusson D, Blajchman MA, et al Clinical outcomes following institution of the Canadian universal leukoreduction program for red blood cell transfusions JAMA 2003;289:19411949 102 Fergusson D, Hebert PC, Lee SK, et al Clinical outcomes following institution of universal leukoreduction of blood transfusions for premature infants JAMA 2003;289:1950-1956 103 Loh YS, Tan S, Kwok M, Stark MJ, Marks DC Reduction of biological response modifiers in the supernatant of washed paediatric red blood cells Vox Sang 2016;111:365-373 104 Cholette JM, Henrichs KF, Alfieris GM, et al Washing red blood cells and platelets transfused in cardiac surgery reduces postoperative inflammation and number of transfusions: results of a prospective, randomized, controlled clinical trial Pediatr Crit Care Med 2012;13:290-299 105 Blumberg N, Heal JM, Rowe JM A randomized trial of washed red blood cell and platelet transfusions in adult acute leukemia [ISRCTN76536440] BMC Blood Disord 2004;4:6 106 O’Leary MF, Szklarski P, Klein TM, Young PP Hemolysis of red blood cells after cell washing with different automated technologies: clinical implications in a neonatal cardiac surgery population Transfusion 2011;51:955-960 107 Silva M Standards for Blood Banks and Transfusion Services Bethesda: AABB; 2004 108 Roseff SD Pediatric transfusion 2nd ed Bethesda: AABB; 2006 109 Tobian AA, Heddle NM, Wiegmann TL, Carson JL Red blood cell transfusion: 2016 clinical practice guidelines from AABB Transfusion 2016;56:2627-2630 110 Robinson S, Harris A, Atkinson S, et al The administration of blood components: a British Society for Haematology Guideline Transfus Med 2018;28:3-21 111 Zimrin AB, Hess JR Current issues relating to the transfusion of stored blood cells Vox Sang 2009;96:93-103 112 Hod EA, Spitalnik SL Stored red blood cell transfusions: iron, inflammation, immunity, and infection Transfus Clin Biol 2012;19:84-89 113 Shih AW, Bhagirath VC, Heddle NM, et al Quantification of cellfree DNA in red blood cell units in different whole blood processing methods J Blood Transfus 2016;55(S3):9A 114 Spinella PC, Perkins JG, Grathwohl KW, et al Risks associated with fresh whole blood and red blood cell transfusions in a combat support hospital Crit Care Med 2007;35:2576-2581 115 Parshuram C, Doyle J, Lau W, Shemie SD Transfusion-associated graft versus host disease Pediatr Crit Care Med 2002;3:57-62 116 Heddle NM, Arnold DM, Acker JP, et al Red blood cell processing methods and in-hospital mortality: a transfusion registry cohort study Lancet Haematol 2016;3:e246-e254 117 Lacroix J, Hébert PC, Fergusson DA, et al Age of transfused blood in critically ill adults N Engl J Med 2015;372:1410-1418 118 Steiner ME, Ness PM, Assmann SF, et al Effects of red-cell storage duration on patients undergoing cardiac surgery N Engl J Med 2015;372:1419-1429 119 Cooper DJ, McQuilten ZK, Nichol A, et al Age of red cells for transfusion and outcomes in critically ill adults N Engl J Med 2017;377(19):1858-1867 120 Heddle NM, Cook RJ, Arnold DM, et al Effect of short-term vs long-term blood storage on mortality after transfusion N Engl J Med 2016;375:1937-1945 121 Fergusson DA, Hébert P, Hogan DL, et al Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birthweight infants: the ARIPI randomized trial JAMA 2012;308:14431451 122 Spinella PC, Dressler A, Tucci M, et al Survey of transfusion policies at US and Canadian children’s hospitals in 2008 and 2009 Transfusion 2010;50:2328-2335 123 Goel R, Johnson DJ, Scott AV, et al Red blood cells stored 35 days or more are associated with adverse outcomes in high-risk patients Transfusion 2016;56:1690-1698 e4 124 Cook RJ, Heddle NM, Lee KA, et al Red blood cell storage and in-hospital mortality: a secondary analysis of the INFORM randomised controlled trial Lancet Haematol 2017;4:e544-E552 doi:10.1016/S2352-3026(17)30169-2 125 Keir AK, Hansen AL, Callum J, Jankov RP, Acker JP Coinfusion of dextrose-containing fluids and red blood cells does not adversely affect in vitro red blood cell quality Transfusion 2014;54:20682076 126 Stanworth SJ, Tinmouth A Plasma transfusion and the use of albumin In: Simon TL, Snyder EK, Solheim BG, Stowell CP, Strauss RG, Petrides M, eds Rossi’s Principles of Transfusion Medicine 4th ed Wiley-Blackwell; 2009:1110 127 Stanworth SJ The evidence-based use of FFP and cryoprecipitate for abnormalities of coagulation tests and clinical coagulopathy Hematology Am Soc Hematol Educ Program 2007:179-186 128 Spinella PC, Frazier E, Pidcoke HF, et al All plasma products are not created equal: Characterizing differences between plasma products J Trauma Acute Care Surg 2015;78(suppl 1):S18-S25 129 Pusateri AE, Given MB, Schreiber MA, et al Dried plasma: state of the science and recent developments Transfusion 2016;56(suppl 2):S128-139 130 Pusateri AE, Butler FK, Shackelford SA, et al The need for dried plasma - a national issue Transfusion 2019;59(suppl 2):15871592 131 Pati S, Peng Z, Wataha K, Miyazawa B, Potter DR, Kozar RA Lyophilized plasma attenuates vascular permeability, inflammation and lung injury in hemorrhagic shock PLoS One 2018;13:e0192363 132 Sarani B, Dunkman WJ, Dean L, Sonnad S, Rohrbach JI, Gracias VH Transfusion of fresh frozen plasma in critically ill surgical patients is associated with an increased risk of infection Crit Care Med 2008;36:1114-1118 133 Karam O, Lacroix J, Robitaille N, Rimensberger PC, Tucci M Association between plasma transfusions and clinical outcome in critically ill children: a prospective observational study Vox Sang 2013;104:342-349 134 Middelburg RA, van de Watering LMG, van der Bom JG Blood transfusions: good or bad? Confounding by indication, an underestimated problem in clinical transfusion research Transfusion 2010;50:1881-1883 135 Camazine MN, Karam O, Colvin R, et al Outcomes related to the use of frozen plasma or pooled solvent/detergent-treated plasma in critically ill children Pediatr Crit Care Med 2017;18:e215-e223 136 Liumbruno G, Bennardello F, Lattanzio A, Piccoli P, Rossetti G, Italian Society of Transfusion Medicine and Immunohaematology (SIMTI) Work Group Recommendations for the transfusion of plasma and platelets Blood Transfus 2009;7:132-150 137 Karam O, Demaret P, Shefler A, et al Indications and effect of plasma transfusions in critically ill children Am J Respir Crit Care Med 2015;191:1395-1402 138 Daley BJ, Miller RS, Harbrecht BG, et al Prehospital plasma during air medical transport in trauma patients at risk for hemorrhagic shock N Engl J Med 2018;379:315-326 139 Spinella PC, Perkins JG, Grathwohl KW, et al Fresh whole blood transfusions in coalition military, foreign national, and enemy combatant patients during Operation Iraqi Freedom at a U.S combat support hospital World J Surg 2008;32:2-6 140 Afshari A, Wikkelsø A, Brok J, Møller AM, Wetterslev J Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion Cochrane Database Syst Rev 2011;16(3):CD007871 141 Wikkelsø A, Wetterslev J, Møller AM, Afshari A Thromboelastography (TEG) or thromboelastometry (ROTEM) to monitor haemostatic treatment versus usual care in adults or children with bleeding Cochrane Database Syst Rev 2016;22(8):CD007871 142 Karam O, Demaret P, Duhamel A, et al Factors influencing plasma transfusion practices in paediatric intensive care units around the world Vox Sang 2017;112:140-149 143 Gurney JM, Kozar RA, Cancio LC Plasma for burn shock resuscitation: is it time to go back to the future? Transfusion 2019;59:15781586 144 Chang R, Holcomb JB, Johansson PI, Pati S, Schreiber MA, Wade CE Plasma resuscitation improved survival in a cecal ligation and puncture rat model of sepsis Shock 2018;49:53-61 145 Chang R, Holcomb JB Choice of fluid therapy in the initial management of sepsis, severe sepsis, and septic shock Shock 2016;46: 17-26 146 Cardenas JC, Cap AP, Swartz MD, et al Plasma resuscitation promotes coagulation homeostasis following shock-induced hypercoagulability Shock 2016;45:166-173 147 Potter DR, Baimukanova G, Keating SM, et al Fresh frozen plasma and spray-dried plasma mitigate pulmonary vascular permeability and inflammation in hemorrhagic shock J Trauma Acute Care Surg 2015;78(suppl 1):S7-S17 148 Watson JJ, Pati S, Schreiber MA Plasma transfusion: History, current realities, and novel improvements Shock 2016;46:468-479 149 Yazer MH, Seheult J, Kleinman S, Sloan SR, Spinella PC Who’s afraid of incompatible plasma? A balanced approach to the safe transfusion of blood products containing ABO-incompatible plasma Transfusion 2018;58:532-538 150 Dunbar NM, Yazer MH, Biomedical Excellence for Safer Transfusion (BEST) Collaborative, and the STAT Study Investigators Safety of the use of group A plasma in trauma: the STAT study Transfusion 2017;57:1879-1884 151 Nellis ME, Karam O, Mauer E, et al Platelet transfusion practices in critically ill children Crit Care Med 2018;46:1309-1317 152 Pidcoke HF, Spinella PC, Ramasubramanian AK, et al Refrigerated platelets for the treatment of acute bleeding: a review of the literature and reexamination of current standards Shock 2014;41(suppl 1):51-53 153 Cap AP, Spinella PC Just chill-it’s worth it! Transfusion 2017; 57:2817-2820 154 Sweeney JD, Lozano M Platelet Transfusion Therapy 2nd ed Bethesda: AABB Press; 2006 155 Shea SM, Thomas KA, Spinella PC The effect of platelet storage temperature on hemostatic, immune, and endothelial function: potential for personalized medicine Blood Transfus 2019;17 In press 156 Kelly K, Dumont JJ Frozen platelets Transfus Apher Sci 2019; 58:23-29 157 Marks DC, Johnson L, Reade MC A clinical trial of frozen platelets: rationale, protocol and pilot analysis plan ISBT Sci Ser 2018;13(3) 158 Noorman F, van Dongen TT, Plat MJ, Badloe JF, Hess JR, Hoencamp R Transfusion: -80 degrees C frozen blood products are safe and effective in military casualty care PLoS One 2016;11:e0168401 159 Cazenave JP, Isola H, Kientz D Pathogen inactivation of platelets In: Sweeney JD, Lozano M, eds Platelet Transfusion Therapy 2nd ed Bethesda: AABB Press; 2006:119-176 160 Schulz WL, McPadden J, Gehrie EA, et al Blood utilization and transfusion reactions in pediatric patients transfused with conventional or pathogen reduced platelets J Pediatr 2019 Epub ahead of print 161 Stroncek DF, Rebulla P Transfusion medicine Platelet transfusions Lancet 2007;370:427-438 162 Du Pont-Thibodeau G, Lacroix J, Ducruet T, Tucci M Platelet transfusions in pediatric intensive care Pediatr Crit Care Med 2016;17:e420-e429 163 Krishnan J, Morrison W, Simone S, Ackerman A Implications of thrombocytopenia and platelet course on pediatric intensive care unit outcomes Pediatr Crit Care Med 2008;9:502-505 164 Gauvin F, Toledano B, Champagne J, Lacroix J Reactive hemophagocytic syndrome presenting as a component of multiple organ system failure Crit Care Med 2000;28:3341-3345 165 Josephson CD, Granger S, Assmann SF, et al Bleeding risks are higher in children versus adults given prophylactic platelet transfusions for treatment-induced hypoproliferative thrombocytopenia Blood 2012;120:748-760 e5 166 Strauss R, Wehler M, Mehler K, Kreutzer D, Koebnick C, Hahn EG Thrombocytopenia in patients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome Crit Care Med 2002;30:1765-1771 167 Lieberman L, Bercovitz RS, Sholapur NS, Heddle NM, Stanworth SJ, Arnold DM Platelet transfusions for critically ill patients with thrombocytopenia Blood 2014;123:1146-1151 168 Slichter SJ Relationship between platelet count and bleeding risk in thrombocytopenic patients Transfus Med Rev 2004;18:153-167 169 Stanworth SJ, Estcourt LJ, Powter G, et al A no-prophylaxis platelet-transfusion strategy for hematologic cancers N Engl J Med 2013;368:1771-1780 170 Curley A, Stanworth SJ, Willoughby K, et al Randomized trial of platelet-transfusion thresholds in neonates N Engl J Med 2019;380:242-251 171 Karam O, Tucci M, Lacroix J, Rimensberger PC, on behalf of the Canadian Critical Care Trials Group, and of the Pediatric Acute Lung Injury and Sepsis Investigator Network International survey on plasma transfusion practices in critically ill children Transfusion 2014;54:1125-1132 172 Thompson CB, Jakubowski JA, Quinn PG, Deykin D, Valeri CR Platelet size and age determine platelet function independently Blood 1984;63:1372-1375 173 Gerday E, Baer VL, Lambert DK, et al Testing platelet mass versus platelet count to guide platelet transfusions in the neonatal intensive care unit Transfusion 2009;49:2034-2039 174 Josephson CD, Su LL, Christensen RD, et al Platelet transfusion practices among neonatalogists in the United States and Canada: results of a survey Pediatrics 2009;123:278-285 175 Blajchman MA, Slichter SJ, Heddle NM, Murphy MF New strategies for the optimal use of platelet transfusions Hematology Am Soc Hematol Educ Program 2008:198-204 176 Nellis ME, Goel R, Karam O, et al Effects of ABO matching of platelet transfusions in critically ill children Pediatr Crit Care Med 2019;20:e61-e69 177 Yazer MH, Spinella PC The use of low-titer group O whole blood for the resuscitation of civilian trauma patients in 2018 Transfusion 2018;58:2744-2746 178 Thomas KA, Shea SM, Yazer MH, Spinella PC Effect of leukoreduction and pathogen reduction on the hemostatic function of whole blood Transfusion 2019;59:1539-1548 179 Allain JP, Owusu-Ofori AK, Assennato SM, Marschner S, Goodrich RP, Owusu-Ofori S Effect of Plasmodium inactivation in whole blood on the incidence of blood transfusion-transmitted malaria in endemic regions: the African Investigation of the Mirasol System (AIMS) randomised controlled trial Lancet 2016;387:1753-1761 180 Spinella P, Holcomb J, Perkins J Warm fresh blood is independently associated with improved survival for patients with combatrelated trauma Crit Care Med 2008;36:A14 181 Spinella PC, Cap AP Whole blood: back to the future Curr Opin Hematol 2016;23:536-542 182 Yazer MH, Cap AP, Spinella PC Raising the standards on whole blood J Trauma Acute Care Surg 2018;84(suppl 1):S14-17 183 Strandenes G, Berséus O, Cap AP, et al Low titer group O whole blood in emergency situations Shock 2014;41(suppl 1):70-75 184 Leeper CM, Yazer MH, Cladis FP, Saladino R, Triulzi DJ, Gaines BA Use of uncrossmatched cold-stored whole blood in injured children with hemorrhagic shock JAMA Pediatr 2018;172:491-492 185 DeSimone RA, Nellis ME, Goel R, Haas T, Vasovic L, Cushing MM Cryoprecipitate indications and patterns of use in the pediatric intensive care unit: inappropriate transfusions and lack of standardization Transfusion 2016;56:1960-1964 186 Kleinman S, Caulfield T, Chan P, et al Toward an understanding of transfusion-related acute lung injury: Statement of a consensus panel Transfusion 2004;44:1774-1789 187 Gauvin F, Lacroix J, Robillard P, Lapointe H, Hume H Acute transfusion reaction in pediatric intensive care unit Transfusion 2006;46:1899-1908 188 Stainsby D, Jones H, Wells AW, Gibson B, Cohen H, on behalf of the SHOT Steering Group Adverse outcomes of blood donation in children: Analysis of UK reports to the serious hazards of transfusion scheme 1996-2005 Br J Haematol 2008;141:73-79 189 Espinosa A, Steinsvag CT, et al Transfusion reactions in children reported to the Norwegian Hemovigilance System (2004-13) Transfusion 2016;56(suppl 4):19A 190 Vossoughi S, Perez G, Whitaker BI, Fung MK, Stotler B Analysis of pediatric adverse reactions to transfusions Transfusion 2018;58: 60-69 191 Cohen H Transfusion-associated circulatory overload (TACO) In: Bolton-Maggs PHB, Poles D, Watt A, Thomas D, on behalf of the Serious Hazards of Transfusion (SHOT) Steering Group, eds The 2013 Annual SHOT Report (2014) London: Serious Hazards of Transfusion; 2014 192 Curtis BR, McFarland JG Mechanisms of transfusion-related acute lung injury (TRALI): Anti-leukocyte antibodies Crit Care Med 2006;34(Suppl 5):S118-S123 193 Silliman CC The two-event model of transfusion-related acute lung injury Crit Care Med 2006;34(suppl 5):S124-131 194 Kopko P, Paglieroni TG, Popovsky MA, Muto KN, MacKenzie MR, Holland PV TRALI: Correlation of antigen-antibody and monocyte activation in donor-recipient pairs Transfusion 2003;43: 177-184 195 Silliman CC, Boshkov LK, Mehdizadehkashi Z, et al Transfusionrelated acute lung injury: Epidemiology and a prospective analysis of etiologic factors Blood 2003;101:454-462 196 Kleinman S, Marshall D, AuBuchon J, Patton M Survival after transfusion as assessed in a large multistate US cohort Transfusion 2004;44:386-390 197 Gauvin F, Robillard P, Hume H, et al Transfusion related acute lung injury in the Canadian paediatric population Paediatr Child Health 2012;17:235-240 198 Moore SB Transfusion-related acute lung injury (TRALI): Clinical presentation, treatment, and prognosis Crit Care Med 2006; 34(suppl 5):S114-S117 199 Marik PE, Corwin HL Acute lung injury following blood transfusion: expanding the definition Crit Care Med 2008;36:30803084 200 Church GD, Matthay MA, Liu K, Milet M, Flori HR Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury Pediatr Crit Care Med 2009; 10:297-302 201 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