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83 Back SA, Han BH, Luo NL, et al Selective vulnerability of late oligodendrocyte progenitors to hypoxia ischemia J Neurosci 2002; 22 455 463 84 Mahle WT, Tavani F, Zimmerman RA, et al An MRI study of[.]

e3 83 Back SA, Han BH, Luo NL, et al Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia J Neurosci 2002; 22:455-463 84 Mahle WT, Tavani F, Zimmerman RA, et al An MRI study of neurological injury before and after congenital heart surgery Circulation 2002;106:I109-I114 85 Galli KK, Zimmerman RA, Jarvik GP, et al Periventricular leukomalacia is common after neonatal cardiac surgery J Thorac Cardiovasc Surg 2004;127:692-704 86 Petit CJ, Rome JJ, Wernovsky G, et al Preoperative brain injury in transposition of the great arteries is associated with oxygenation and time to surgery, not balloon atrial septostomy Circulation 2009;119: 709-716 87 Newburger JW, Jonas RA, Wernovsky G, et al A comparison of the perioperative neurologic effects of hypothermic circulatory arrest versus low-flow cardiopulmonary bypass in infant heart surgery N Engl J Med 1993;329:1057-1064 88 Limperopoulos C, Majnemer A, Shevell MI, et al Predictors of developmental disabilities after open heart surgery in young children with congenital heart defects J Pediatr 2002;141:51-58 89 Anand KJ, Hickey PR Halothane-morphine compared with highdose sufentanil for anesthesia and postoperative analgesia in neonatal cardiac surgery N Engl J Med 1992;326:1-9 90 van Dijk M, de Boer JB, Koot HM, Tibboel D, Passchier J, Duivenvoorden HJ The reliability and validity of the COMFORT scale as a postoperative pain instrument in to 3-year-old infants Pain 2000;84:367-377 91 Johansson M, Kokinsky E The COMFORT behavioural scale and the modified FLACC scale in paediatric intensive care Nurs Crit Care 2009;14:122-130 92 Kerson AG, DeMaria R, Mauer E, et al Validity of the Richmond Agitation-Sedation Scale (RASS) in critically ill children J Intensive Care 2016;4:65 93 Garcia Guerra G, Robertson CM, Alton GY, et al Neurotoxicity of sedative and analgesia drugs in young infants with congenital heart disease: 4-year follow-up Paediatr Anaesth 2014;24:257-265 94 Traube C, Silver G, Gerber LM, et al Delirium and mortality in critically ill children: epidemiology and outcomes of pediatric delirium Crit Care Med 2017;45:891-898 95 Herrup EA, Wieczorek B, Kudchadkar SR Characteristics of postintensive care syndrome in survivors of pediatric critical illness: a systematic review World J Crit Care Med 2017;6:124-134 96 Girard TD, Jackson JC, Pandharipande PP, et al Delirium as a predictor of long-term cognitive impairment in survivors of critical illness Crit Care Med 2010;38:1513-1520 97 Sockalingam S, Parekh N, Bogoch, II, et al Delirium in the postoperative cardiac patient: a review J Card Surg 2005;20:560-567 98 Traube C, Silver G, Reeder RW, et al Delirium in critically ill Children: An International Point Prevalence Study Crit Care Med 2017;45:584-590 99 Patel AK, Biagas KV, Clarke EC, et al Delirium in children after cardiac bypass surgery Pediatr Crit Care Med 2017;18:165-171 100 Lucas SS, Nasr VG, Ng AJ, Joe C, Bond M, DiNardo JA Pediatric cardiac intensive care society 2014 consensus statement: pharmacotherapies in cardiac critical care: sedation, analgesia and muscle relaxant Pediatr Crit Care Med 2016;17:S3-S15 101 Traube C, Silver G, Kearney J, et al Cornell Assessment of Pediatric Delirium: a valid, rapid, observational tool for screening delirium in the PICU* Crit Care Med 2014;42:656-663 102 Carollo DS, Nossaman BD, Ramadhyani U Dexmedetomidine: a review of clinical applications Curr Opin Anaesthesiol 2008; 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discussion 423-424 204 Heck Jr HA, Schieken RM, Lauer RM, Doty DB Conduit repair for complex congenital heart disease Late follow-up J Thorac Cardiovasc Surg 1978;75:806-814 205 Brown JW, Ruzmetov M, Rodefeld MD, Vijay P, Darragh RK Valved bovine jugular vein conduits for right ventricular outflow tract reconstruction in children: an attractive alternative to pulmonary homograft Ann Thorac Surg 2006;82:909-916 206 Fiore AC, Ruzmetov M, Huynh D, et al Comparison of bovine jugular vein with pulmonary homograft conduits in children less than years of age Eur J Cardiothorac Surg 2010;38:318-325 207 Anyanwu E, Klemm C, Achatzy R, et al Surgery of coarctation of the aorta: a nine-year review of 253 patients Thorac Cardiovasc Surg 1984;32:350-357 208 McCrindle BW, Jones TK, Morrow WR, et al Acute results of balloon angioplasty of native coarctation versus recurrent aortic obstruction are equivalent Valvuloplasty and Angioplasty of Congenital Anomalies (VACA) Registry Investigators J Am Coll Cardiol 1996;28:1810-1817 e6 209 Ashburn DA, McCrindle BW, Tchervenkov CI, et al Outcomes after the Norwood operation in neonates with critical aortic stenosis or aortic valve atresia J Thorac Cardiovasc Surg 2003;125: 1070-1082 210 Kumar RK, Newburger JW, Gauvreau K, Kamenir SA, Hornberger LK Comparison of outcome when hypoplastic left heart syndrome and transposition of the great arteries are diagnosed prenatally versus when diagnosis of these two conditions is made only postnatally Am J Cardiol 1999;83:1649-1653 211 Iannettoni MD, Bove EL, Mosca RS, et al Improving results with first-stage palliation for hypoplastic left heart syndrome J Thorac Cardiovasc Surg 1994;107:934-940 212 Donner RM Hypoplastic left heart syndrome Curr Treat Options Cardiovasc Med 2000;2:469-480 213 Mahle WT, Spray TL, Wernovsky G, Gaynor JW, Clark BJ III Survival after reconstructive surgery for hypoplastic left heart syndrome: A 15-year experience from a single institution Circulation 2000;102:III136-III141 214 Mosca RS, Bove EL, Crowley DC, Sandhu SK, Schork MA, Kulik TJ Hemodynamic characteristics of neonates following first stage palliation for hypoplastic left heart syndrome Circulation 1995;92:II267-II271 215 Norwood WI, Lang P, Hansen DD Physiologic repair of aortic atresia-hypoplastic left heart syndrome N Engl J Med 1983;308: 23-26 216 Daebritz SH, Nollert GD, Zurakowski D, et al Results of Norwood stage I operation: comparison of hypoplastic left heart syndrome with other malformations J Thorac Cardiovasc Surg 2000;119:358-367 217 Tabbutt S, Ramamoorthy C, Montenegro LM, et al Impact of inspired gas mixtures on preoperative infants with hypoplastic left heart syndrome during controlled ventilation Circulation 2001;104:I159-I164 218 Bradley SM, Simsic JM, Atz AM Hemodynamic effects of inspired carbon dioxide after the Norwood procedure Ann Thorac Surg 2001;72:2088-2093; discussion 2093-2094 219 Hoffman GM, Tweddell JS, Ghanayem NS, et al Alteration of the critical arteriovenous oxygen saturation relationship by sustained afterload reduction after the Norwood procedure J Thorac Cardiovasc Surg 2004;127:738-745 220 Sano S, Ishino K, Kawada M, et al Right ventricle-pulmonary artery shunt in first-stage palliation of hypoplastic left heart syndrome J Thorac Cardiovasc Surg 2003;126:504-509; discussion 509-510 221 Sano S, Ishino K, Kawada M, Honjo O Right ventricle-pulmonary artery shunt in first-stage palliation of hypoplastic left heart syndrome Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2004;7:22-31 222 Ohye RG, Sleeper LA, Mahony L, et al Comparison of shunt types in the Norwood procedure for single-ventricle lesions N Engl J Med 2010;362:1980-1992 223 Newburger JW, Sleeper LA, Frommelt PC, et al Transplantationfree survival and interventions at years in the single ventricle reconstruction trial Circulation 2014;129:2013-2020 224 Bailey LL, Gundry SR, Razzouk AJ, Wang N, Sciolaro CM, Chiavarelli M Bless the babies: one hundred fifteen late survivors of heart transplantation during the first year of life The Loma Linda University Pediatric Heart Transplant Group J Thorac Cardiovasc Surg 1993;105:805-814; discussion 814-815 225 Armitage JM, Fricker FJ, del Nido P, Starzl TE, Hardesty RL, Griffith BP A decade (1982 to 1992) of pediatric cardiac transplantation and the impact of FK 506 immunosuppression J Thorac Cardiovasc Surg 1993;105:464-472; discussion 472-473 226 Starnes VA, Griffin ML, Pitlick PT, et al Current approach to hypoplastic left heart syndrome Palliation, transplantation, or both? J Thorac Cardiovasc Surg 1992;104:189-194; discussion 194-195 227 Freedom RM Neurodevelopmental outcome after the Fontan procedure in children with the hypoplastic left heart syndrome and other forms of single ventricle pathology: challenges unresolved J Pediatr 2000;137:602-604 228 Wernovsky G, Stiles KM, Gauvreau K, et al Cognitive development after the Fontan operation Circulation 2000;102:883-889 229 Barron DJ, Kilby MD, Davies B, Wright JG, Jones TJ, Brawn WJ Hypoplastic left heart syndrome Lancet 2009;374:551-564 230 Galantowicz M, Cheatham JP Lessons learned from the development of a new hybrid strategy for the management of hypoplastic left heart syndrome Pediatr Cardiol 2005;26:190-199 231 Akinturk H, Michel-Behnke I, Valeske K, et al Hybrid transcatheter-surgical palliation: basis for univentricular or biventricular repair: the Giessen experience Pediatr Cardiol 2007;28:79-87 232 Pizarro C, Derby CD, Baffa JM, Murdison KA, Radtke WA Improving the outcome of high-risk neonates with hypoplastic left heart syndrome: hybrid procedure or conventional surgical palliation? Eur J Cardiothorac Surg 2008;33:613-618 233 Galantowicz M, Cheatham JP, Phillips A, et al Hybrid approach for hypoplastic left heart syndrome: intermediate results after the learning curve Ann Thorac Surg 2008;85:2063-2070; discussion 2070-2071 234 Pizarro C, Murdison KA, Derby CD, Radtke W Stage II reconstruction after hybrid palliation for high-risk patients with a single ventricle Ann Thorac Surg 2008;85:1382-1388 235 Bacha EA, Daves S, Hardin J, et al Single-ventricle palliation for high-risk neonates: the emergence of an alternative hybrid stage I strategy J Thorac Cardiovasc Surg 2006;131:163-171.e2 e7 Abstract: The neonatal myocardium is less compliant than that of the older child, less tolerant of increases in afterload, and less responsive to increases in preload A predictable decrease in cardiac index typically occurs to 12 hours after separation from cardiopulmonary bypass, but milrinone administration during the early postoperative period may attenuate this phenomenon Patients with postoperative low cardiac output require careful evaluation for unanticipated residual lesions Patients with restrictive physiology from hypertrophy and diastolic dysfunction of the right ventricle may require high right-sided filling pressures to achieve adequate cardiac output, making them prone to hepatic congestion, anasarca, pleural effusions, and ascites Inhaled nitric oxide plays an important role in the management of postoperative pulmonary hypertension in the cardiac intensive care unit Hypoxemia after bidirectional cavopulmonary anastomosis generally is a sign of decreased pulmonary blood flow related to reduced cardiac output Liberation from positive-pressure mechanical ventilation should be accomplished as soon as feasible, particularly in patients after a cavopulmonary anastomosis (bidirectional Glenn) or Fontan operation because spontaneous breathing improves pulmonary blood flow, arterial oxygen saturation, and ventricular preload Ventricular ectopy and elevated atrial pressures after the arterial switch operation should raise suspicion of myocardial ischemia from insufficient coronary blood flow Postoperative care of the patient with hypoplastic left heart syndrome after stage I palliation (Norwood procedure) may require delicate balancing of the pulmonary and systemic blood flows A high arterial oxygen saturation denotes excessive pulmonary blood flow and in patients with impaired ventricular output is generally accompanied by inadequate systemic blood flow, acidosis, and end-organ dysfunction Key words: cavopulmonary shunt, hybrid procedure, Fontan procedure, Norwood procedure, interrupted aortic arch, coarctation of the aorta, hypoplastic left heart syndrome, transposition of the great arteries, single ventricle ... cavopulmonary connection Ann Thorac Surg 2012;93:1254-1260; discussion 1261 140 Booth KL, Roth SJ, Thiagarajan RR, Almodovar MC, del Nido PJ, Laussen PC Extracorporeal membrane oxygenation support... cardiopulmonary bypass, but milrinone administration during the early postoperative period may attenuate this phenomenon Patients with postoperative low cardiac output require careful evaluation for unanticipated... after a cavopulmonary anastomosis (bidirectional Glenn) or Fontan operation because spontaneous breathing improves pulmonary blood flow, arterial oxygen saturation, and ventricular preload Ventricular

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