866 lar secretion, ultimately resulting in only 10–20% of the drug being secreted into the tubular lumen [30] Therefore, higher doses (2–5 mg/kg/dose) should be considered in AKI [31] However, the ris[.]
C Mammen and D Askenazi 866 lar secretion, ultimately resulting in only 10–20% of the drug being secreted into the tubular lumen [30] Therefore, higher doses (2–5 mg/kg/dose) should be considered in AKI [31] However, the risk of ototoxicity increases with higher doses due to decreased clearance of the drug If there is a positive response to furosemide, the drug can be continued either as repeat bolus dosing or continuous infusion Even though a term infant can get be dosed every 6 hours, the half-life is prolonged in premature infants Therefore, furosemide should only be administered every 12 hours in those ≥32 weeks gestational age (GA) and every 24 hours in those