2019-WMRUGS-Program-and-Recruiter-Contact-Information-VAI-November-9

SCHEDULE OF EVENTS SATURDAY, NOVEMBER 9, 2019 8:00 AM ARRIVAL AND POSTER SETUP Vande Woude Sessions Conference Room and Cook-Hauenstein Hall 8:15 AM RECRUITER ARRIVAL AND SETUP 9:00 AM WELCOME Steve Triezenberg, PhD Dean, Van Andel Institute Graduate School and WMRUGS Master of Ceremonies Tomatis Auditorium 9:15 AM KEYNOTE SPEAKER ADDRESS Paloma Vargas, PhD Assistant Professor of Biology and Director, Hispanic-Serving Institute Initiatives California Lutheran University “Learning Through Research: Life Lessons from a Latinx Biologist” Tomatis Auditorium 10:00 AM POSTER SESSION I Presenters at even-numbered posters 11:25 AM GRADUATE STUDENT RESEARCH TALK Zach DeBruine, PhD Candidate – Van Andel Institute Graduate School “Frizzled GPCRs initiate and amplify signaling through independent mechanisms” Tomatis Auditorium 11:40 AM UNDERGRADUATE STUDENT RESEARCH TALKS Svetlana Djirackor, Aquinas College “Subcloning of zebrafish NOD1 alleles into UAS:P2A-nls-EGFP for investigation of NOD1’s role in hematopoietic stem cell development” Tomatis Auditorium DeVos Lobby Vande Woude Sessions Conference Room and Cook-Hauenstein Hall Liam Ferraby, Calvin University “The Science of Providing Services Spatially for Returning Citizens” 12:10 PM LUNCH Lunch seating is available in the café, conference rooms 3104 & 3105, the pre-function area outside of conference rooms 3104 & 3105 and Tomatis Auditorium 12:35 PM RECORDED TED TALKS Please join us in the auditorium to watch recorded TED Talks 1:10 PM POSTER SESSION II Presenters at odd-numbered posters 2:35 PM UNDERGRADUATE STUDENT RESEARCH TALKS Katelyn Brown, Ferris State University – College of Pharmacy “Metabolic Engineering for Production of Novel Tetracenomycins” Cook-Hauenstein Hall Tomatis Auditorium Vande Woude Sessions Conference Room and Cook-Hauenstein Hall Tomatis Auditorium Erin Reasoner, Grand Valley State University “Dopamine D2 receptor activation regulates aversive effects of methamphetamine” Alicia Bostwick, Hope College “Investigating Mechanisms of Regulation of Mitochondrial DNA Transcription” Mya Gough, Kalamazoo College “Design and Synthesis of Maleimide-Tryptamine Hybrids as Potential Antibacterial Agents” 3:35 PM CONCLUSION Graduate School, medical school, professional master’s program and internship/employment recruiters/representatives are located in the DeVos Lobby Start and end times for recruiters/representatives will vary A list of recruiters/representatives, their contact information, and their availability is provided on pages 33-39 Page of 39 WEST MICHIGAN REGIONAL UNDERGRADUATE SCIENCE RESEARCH CONFERENCE ACKNOWLEDGEMENTS Costs for the 2019 West Michigan Regional Undergraduate Science Research Conference are underwritten by our title sponsor Gentex Corporation, memorial sponsor Generous Gifts Honoring Dr Gordon Van Harn, poster session sponsors Ferris State University’s College of Pharmacy and Grand Valley State University, supporting sponsor Western Michigan University’s The Graduate College, as well as by the following organizing institutions: Aquinas College, Calvin University, Ferris State University – College of Pharmacy, Grand Valley State University, Hope College, Kalamazoo College, and Van Andel Institute Graduate School TITLE SPONSOR MEMORIAL SPONSOR POSTER SESSION SPONSOR POSTER SESSION SPONSOR SUPPORTING SPONSORS Page of 39 ADDITIONAL ACKNOWLEDGEMENTS – COMMITTEE AND SUPPORT STAFF WMRUGS ORGANIZING INSTITUTIONS AND ORGANIZING COMMITTEE Elizabeth Jensen, PhD – Aquinas College Keith Grasman, PhD – Calvin University Eric Nybo, PhD – Ferris State University, College of Pharmacy Mark Staves, PhD – Grand Valley State University Kristin Dittenhafer-Reed, PhD – Hope College Dwight Williams, PhD – Kalamazoo College Mary Winn, PhD – Van Andel Institute Graduate School / Van Andel Research Institute WMRUGS HOST Thank you to Van Andel Institute for hosting the West Michigan Regional Undergraduate Science Research Conference for 13 years! WMRUGS SUPPORT STAFF Cover images designed by Frank Brenner, VAI Communications & Marketing Associate Social media administration and support provided by Alex Edema and Zane McMillin, Associates – VAI Communications & Marketing, Caitlin Smith, Senior Administrative Assistant – Communications & Marketing and Kayla Habermehl, Science Communications Specialist – Office of the Chief Scientific Officer Administrative support provided by Michelle Love, Van Andel Institute Graduate School staff, the graduate students of Van Andel Institute Graduate School and the post-doctoral fellows from Van Andel Research Institute Audiovisual services provided by Terry Ballard and Bill Baillod with Van Andel Institute Production Services, and Tim Sundt with Viking Creative, LLC Catering services provided by Eurest Dining Services Page of 39 Page of 39 KEYNOTE SPEAKER 9:15 AM | Tomatis Auditorium Paloma Vargas, PhD Assistant Professor of Biology and Director, Hispanic-Serving Institute Initiatives California Lutheran University “Learning Through Research: Life Lessons from a Latinx Biologist” For more information on Dr Vargas, visit: https://www.callutheran.edu/faculty/profile.html?id=palomav In this Keynote Address, Dr Paloma Vargas, will discuss the roles of mentoring and research on the success of students from underserved backgrounds Dr Vargas will provide anecdotes from her own lived experiences on the impact of mentoring, being a mentored, and working in research have had on her own career trajectory & how this has influenced her work in diversity and inclusion in higher education Dr Vargas will also share highimpact practices to promote student success Dr Vargas is an Assistant Professor in Biology and the serves as the Director of Hispanic-Serving Institute Initiatives at California Lutheran University in Thousand Oaks, CA Page of 39 GRADUATE STUDENT RESEARCH TALK 11:25 AM – 11:40 AM | Tomatis Auditorium Zach DeBruine, PhD Candidate – Van Andel Institute Graduate School Molecular and Cellular Biology Research Mentor: Karsten Melcher, PhD – Lead Investigator: Structural Biology and Biochemistry, Van Andel Institute   Scientific Talk Emphasis: Biochemistry Co-Author(s): Karsten Melcher, PhD “Frizzled GPCRs initiate and amplify signaling through independent mechanisms” Membrane receptors are typically thought of as molecular switches which are flipped on and off upon ligand binding However, the interactome around each of these proteins is exceedingly complex, and sometimes the activity of these receptors are carefully tuned by multiple regulatory pathways and activation mechanisms A few years ago, we made the perplexing observation that Frizzled G-protein Coupled Receptors (GPCRs) lacking a ligand-binding domain were still able to signal We investigated how this was possible, and learned that there are two independent mechanisms through which Frizzleds can either initiate, or amplify, signaling This finding changes how we view Wnt pathway regulation and pharmacology It is also yet another example of how perplexing observations should be explored, not ignored Student Profile: https://vaigs.vai.org/students-alumni/students/zach-debruine/ Alumnus: Hope College, Bachelor of Science, Biochemistry and Molecular Biology, 2015 Page of 39 UNDERGRADUATE STUDENT RESEARCH TALKS 11:40 AM – 12:10 PM | Tomatis Auditorium Svetlana Djirackor, Aquinas College Major(s): Biology Class of 2020 Research Mentor(s): L Robert Peters, Jr., PhD – Associate Professor of Biology, Aquinas College  Scientific Talk Emphasis: Immunology  Co-Author(s): Lucas Topie and L Robert Peters, Jr., PhD “Subcloning of zebrafish NOD1 alleles into UAS:P2A-nls-EGFP for investigation of NOD1’s role in hematopoietic stem cell development” Abstract: NOD1 is a dimeric pattern recognition receptor of the innate immune system, encoded by the NOD1 gene This protein recognizes bacterial pathogens and, upon recognition, it is activated and initiates an immune response NOD1 activation has been implicated in the mobilization of hematopoietic stem cells (HSCs) yet the underlying mechanism of this process remains elusive To further explore the role of NOD1 in HSC development, we used the recombinational cloning system, In-Fusion® (Clontech) Cloning to subclone zebrafish dominant-negative NOD1 alleles (L36Q and K202R) formerly designed by our group and the NOD1 wild type allele (NOD1 WT) into the plasmid UAS:P2A-nls-EGFP Our collaborators will use this plasmid, flanked by Tol2 recognition sites, to integrate the sequence of interest into the zebrafish genome and thus monitor the role of NOD1 in HSC development Liam Ferraby, Calvin University Major(s): Environmental Studies Class of 2020 Research Mentor(s): Jason VanHorn, PhD – Assistant Professor and Department Co-Chair, Geology, Geography and Environmental Studies, Calvin University  Scientific Talk Emphasis: Immunology  Co-Author(s): Dr Jason VanHorn, Dr Kevin den Dulk, and Annalane Miller “The Science of Providing Services Spatially for Returning Citizens” Abstract: Resources available to returning citizens (released from prison) for locating service provider assistance are often difficult to use and incapable of providing the necessary support required for a successful reentry back into society This problem generated a need for an improved method of providing returning citizens with the fundamental support vital to the success of the reentry process Over the past three years, our team has developed a GIS based solution to improve the ability of returning citizens to find the service providers that they need The major deliverable has been a web mapping application that functions as a tool allowing returning citizens, their family, and parole officers to locate service providers which are often needed in reentry Following the success of the web mapping application, the development of a native application was initiated, and is currently underway Because of the application’s success, our team is continuing our research and growing the database of service providers Our team has created an application which allows the user to access an ever-improving database of categorized and geolocated service providers in a user friendly and accessible online application (gis.calvin.edu/rc) The application allows the user to search through the counties currently covered, filter through service provider categories, search for nearby providers, as well as easily use several other tools and features Page of 39 UNDERGRADUATE STUDENT RESEARCH TALKS 2:35 PM – 3:35 PM | Tomatis Auditorium Katelyn Brown, Ferris State University – College of Pharmacy Major(s): Biotechnology Class of 2022 Research Mentor(s): Eric Nyob, PhD – Associate Professor of Medicinal Chemistry - Pharmaceutical Science, Ferris State University College of Pharmacy  Scientific Talk Emphasis: Biosynthesis  Co-Author(s): Marlon Coe II and S Eric Nybo PhD “Metabolic Engineering for Production of Novel Tetracenomycins” Abstract: Streptomyces olivaceus produces the anthracycline anticancer agent elloramycin, which features an 8-O-glycosidically linked L-rhamnose sugar Previously, the biosynthetic genes for production of elloramycin were cloned onto cosmid cos16F4 and heterologously expressed in Streptomyces lividans TK24 to produce the aglycone 8-demethyl tetracenomycin C (8-DMTC) Interestingly, cos16F4 lacks the biosynthetic genes to synthesize TDP-L-rhamnose, however, expression of a “sugar plasmid” encoding TDP-Lrhamnose biosynthesis in S lividans (cos16F4) results in production of elloramycin ElmGT has been shown to be a TDP-deoxysugar promiscuous glycosyltransferase responsible for the transfer of >20 different deoxysugar substrates to 8-DMTC, resulting in production of novel elloramycins with diversified anticancer activities In this work, we optimized a heterologous polyketide glycosylation pathway via balancing of TDP-deoxysugar donor and polyketide acceptor substrates First, we overexpressed the Streptomyces coelicolor acetylCoA carboxylase (accA2BE) genes to enhance malonyl-CoA production We hypothesized that this would result in greater carbon flux towards synthesis of 8-DMTC Secondly, we engineered S lividans (cos16F4) with “sugar plasmids” for production of TDP-D-olivose, TDP-L-olivose, and TDP-L-rhamnose to determine production of glycosylated analogues For this purpose, we expressed variant genes encoding TDP-D-glucose synthase and TDP-D-glucose- 4,6-dehydratase (desIII-desIV, mtmD-mtmE, and oleS-oleE) to evaluate their differing in vivo kinetic properties Third, we cloned the optimal gene combinations in high-copy number (e.g pWHM3-oriT) and lowcopy number (e.g pENTG1) vectors to determine the effect of gene dosage on polyketide glycosylation This production platform opens the door for glycodiversification of other anthracycline natural products for the synthesis of improved analogs Erin Reasoner, Grand Valley State University Major(s): Cell & Molecular Biology and Behavioral Neuroscience Class of 2020 Research Mentor(s): Shkelzen Shabani, PhD – Assistant Professor of Biomedical Sciences, Grand Valley State University  Scientific Talk Emphasis: Neuroscience  Co-Author(s): Kalyn Peterson, Leo Gallagher, and Shkelzen Shabani, PhD “Dopamine D2 receptor activation regulates aversive effects of methamphetamine” Abstract: Innate avidity for methamphetamine (MA) use is influenced by sensitivity to its rewarding and aversive effects MA induces these effects through mass release of the neurotransmitter dopamine, stimulating receptors throughout the mesocorticolimbic pathway, including dopamine D2 receptor (D2R) Presently, little is known about the extent to which D2R contributes to MA induced motivational effects and how it may be influenced by other genetic risk factors In this study, we sought to investigate motivational effects of D2R activation by using a genetic mouse model in which mice were selectively bred for low MA drinking (MALDR) and high MA drinking (MAHDR) Mice were subjected to a condition place preference (CPP) procedure wherein administration of a D2R agonist, quinpirole, at doses of 0.1 and 0.5 mg/kg was paired with specific contextual cues Subjects were later tested in the presence and absence of the drug for CPP or aversion (CPA) Thermic responses to quinpirole were also measured at the end of the experiment, as MA has shown opposite thermic effects on MALDR and MAHDR mice In MALDR and MAHDR mice, quinpirole induced significant CPA in both drug-free and drug present CPP tests Additionally, locomotor sensitization, regardless of dose, was observed in a drug-free CPP test only in MALDR mice Locomotor suppression was identified in both mouse lines across both doses Thermic responses to quinpirole after chronic exposure were negligible This study suggests a that D2R stimulation is robustly aversive in both lines, though, locomotor sensitization is differently affected in the selected lines This suggests that locomotor activation via D2R is influenced by genetic risk factors for MA intake Page of 39 UNDERGRADUATE STUDENT RESEARCH TALKS – ABSTRACTS 2:35 PM – 3:35 PM | Tomatis Auditorium Alicia Bostwick, Hope College Major(s): Biology Class of 2020 Research Mentor(s): Kristin Dittenhafer-Reed, PhD – Assistant Professor of Chemistry, Hope College  Scientific Talk Emphasis: Biochemistry  Co-Author(s): Mackenna Senti, Gonzalo Moya, Julia Wilson, and Alexandra Wyeth “Investigating Mechanisms of Regulation of Mitochondrial DNA Transcription” Abstract: Mitochondria produce ATP, the energy currency of cells Mitochondria contain DNA molecules (mtDNA) which encode part of the protein machinery for ATP production; the remaining proteins are encoded by nuclear genes Coordinating gene expression between the mtDNA and the nucleus is critical for assembling the ATP production machinery and generating ATP However, there lacks an understanding of how mtDNA transcription, an important step in this process, is regulated One potential regulatory mechanism is reversible post-translational modifications (PTMs) of proteins associated with mtDNA Two of these proteins, POLRMT and TFB2M, comprise part of the core mtDNA transcription machinery We believe PTMs at specific sites may influence these proteins’ interactions with each other and the mtDNA We have shown that TFB2M phosphorylation affects its ability to bind mtDNA and may influence its binding to POLRMT Continued investigation will provide foundational understanding of mitochondrial biochemistry which can be applied in comprehending human disease Mya Gough, Kalamazoo College Major(s): Chemistry Class of 2020 Research Mentor(s): Dwight Williams, PhD – Roger F and Harriet G Varney Assistant Professor of Chemistry, Kalamazoo College  Scientific Talk Emphasis: Organic Synthesis  Co-Author(s): Dwight Williams, PhD “Design and Synthesis of Maleimide-Tryptamine Hybrids as Potential Antibacterial Agents” Abstract: Antibacterial resistance is developing into a significant health challenge of the 21st century Presently, there is a finite number of molecular scaffolds displaying antibacterial activity that are FDA approved This limited structural diversity restricts the mechanisms available that can be targeted This study used molecular hybridization as a design strategy to develop a novel molecular scaffold with a potentially unique mechanism of action Specifically, maleimides, a class of nitrogen containing heterocycles, were hybridized with tryptamine, the biochemical precursor of tryptophan Each scaffold has shown antimicrobial activity through mechanisms of action previously not exploited The desired N-substituted maleimide hybrids could be obtained in yields ranging from 15-81% over a four-step synthetic route The synthesized compounds were screened against different strains of Proteus vulgaris in Kirby Bauer Disk Assays Results indicate that some of the hybrid compounds maintain antibacterial activity but are selective for one strain over the others Page of 39 SUPPORTING SPONSOR POSTER SESSION SPONSORS Page 10 of 39 86 Laura Dykstra, Calvin University Ecotoxicology Co-Presenter(s): Abigail Triemstra, Gillian Gardner Co-Author(s): Keith Grasman “Monitoring Colonial Waterbirds as Indicators for Reproductive and Immunological Impairments at Contaminated Great Lakes Sites during 2010-19” 87 Chandler Breit, Hope College Engineering Co-Author(s): Dr Courtney Peckens “Power Consumption Considerations for Wireless Acoustic Sensor Networks” 88 Amelia Davis, Kalamazoo College Entomology Co-Author(s): Steven Van Timmeren “Optimizing the Salt Filter Test to Monitor Spotted Wing Drosophila Larvae in Blueberries” 89 Adeline Steele, Muskegon Community College Environmental Science Co-Presenter(s): Jordyn Hallberg Co-Author(s): Darren Mattone “A preliminary study examining the relationship between water quality and the presence of freshwater sponges in the White River Watershed” 90 Savannah Slikkers, Ferris State University Forensic Biology Co-Author(s): Stacy Thurber, Bradley Isler, Doug Workman “Determination of Pig Corpse DNA from Fly Larvae Using Qualitative and Quantitative PCR” 91 Courtney Larson, Grand Valley State University Functional Analysis of TERT Co-Author(s): Dr Agnieszka Szarecka “Structural and Normal Mode Analyses of Function and Inhibition of the Telomerase Catalytic Domain” 92 Morgan Sanders, Michigan State University Genetic Anthropology Co-Author(s): Dr Jeremy Prokop “Population and Database Assessment of Ethnically Diverse CFTR Variants and Cystic Fibrosis potential” 93 Ashley Rice, Indiana Wesleyan University Host Pathogen Interaction Co-Author(s): Jeremy Gross, Hannah Hartzler, Hannah Vandusen, Dr Jolie Leonard “Development of biochemical tools for analysis of HIV-1 Nef-dependant Hck activation and viral packaging” 94 Brianna Bush, Grand Valley State University Immunology Co-Presenter(s): Caitlyn Koseba and Jessica Terrian Co-Author(s): Kristin Renkema “Impact of Microbial Experience on the Immune System Using a Mouse Model” Page 25 of 39 95 Svetlana Djirackor, Aquinas College Immunology Co-Presenter(s): Lucas Topie Co-Author(s): L Robert Peters, Jr., PhD “Subcloning of zebrafish NOD1 alleles into UAS:P2A-nls-EGFP for investigation of NOD1’s role in hematopoietic stem cell development” 96 Brianna Callahan, Michigan State University Immunology Co-Author(s): Ananth Kumar Kammala and Hariharan Subramanian “Lactic Acid inhibits MRGPRX2-mediated mast cell responses” 97 Claudia Stroupe, Kalamazoo College Immunology / Virology “Simian Immunodeficiency Virus (SIV) rebound observed in the rhesus macaque model four days after antiretroviral therapy interruption” 98 Ryan Storteboom, Calvin University Inorganic Chemistry Co-Author(s): Professor Douglas Vander Griend “Determining Binding Constants between Nickel(ll) and Various Amine Ligands in a Competing Solution” 99 Esther Cha, Calvin University Inorganic Chemistry “Enhancing Sivvu.org” 100 Fenton Lawler, Calvin University Inorganic Chemistry Co-Author(s): Douglas A Vander Griend, Ph.D “UV Vis Titration Chemistry: Procedures and Viable Systems” 101 Aaron Batke, Aquinas College Inorganic Chemistry Co-Author(s): Dr Elizabeth Jensen “Synthesis and Characterization of Dimethyl-dioctadecylammonium pentachlorosamarate(III)” 102 Victorialyn Regan, Kalamazoo College Marine Chemistry Co-Author(s): Dr Robert F Chen, Shannon Davis “The Impact of Algal Biofilms on the Microenvironment of Concrete Substrates” 103 Anna Putnam, Aquinas College Mathematics Co-Author(s): Dr Joseph Fox “The Mathematics of Image Recognition” 104 Eric Leu, Hope College Mathematics / Mathematical Biology Co-Author(s): Brian Yurk “The Identification of Cloud Forest Landslides in Monteverde, Costa Rica, Using High-Resolution Satellite Imagery and Machine Learning” Page 26 of 39 105 Austin Cramer, Kalamazoo College Mathematics / Mathematical Virology Co-Author(s): David Wilson “Understanding the Hidden Higher Dimensional Symmetry in Viruses” 106 Paul Steenwyk, Calvin University Mechanical Engineering “The story of worldwide muscle work from 1800-2015” 107 Alexandra Gemmen, Grand Valley State University Medical Co-Author(s): Dr John Capodilupo “Analysis of Insulin-Dependent Diabetes Mellitus” 108 Nicholas Sienkiewicz, Western Michigan University Medicinal Chemistry Co-Presenter(s): John Getson Co-Author(s): Dr Kelly Teske “Synthesis and Identification of miRNA-31 Inhibitors” 109 Yanari Raines, Western Michigan University Medicinal Chemistry Co-Author(s): Dr Kelly A Teske “The Synthesis of 2,4-diphenyl-quinazoline Analogues to Globally Upregulate Tumor Suppressive MicroRNA in Breast Cancer” 110 Marlon Coe II, Ferris State University Metabolic Engineering Co-Author(s): Katelyn Brown, Dr S Eric Nybo “Metabolic engineering for optimization of nogalamycin production” 111 Andrew Lybbert, Michigan State University Metabolomics Co-Author(s): Ruma Raghuvanshi, Robert Quinn “Characterization of Specialized Metabolites in Pseudomonas aeruginosa” 112 Alyssa Nugent, Indiana Wesleyan University Microbiology Co-Presenter(s): Kenzie Hayward, Emma Brown, and Sarah O’Deens Co-Author(s): Alyssa Nugent, Kenzie Hayward, Emma Brown, Sarah O’Deens, Julie Webster, and Dr Tara Renbarger “Antimicrobial Use and Extraction of Essential Oils” 113 Janessa George, Indiana Wesleyan University Microbiology Co-Presenter(s): Brittney Alexander Co-Author(s): Dr Matthew Sattley “Cultivation and characterization of icebound microorganisms from the South Pole” Page 27 of 39 114 Mackenzie Bontrager, Cornerstone University Microbiology Co-Presenter(s): Anna Johnson Co-Author(s): Robert Keys, PhD “Dangerous Waters of Cornerstone University” 115 Tyler Quick, Grand Valley State University Microbiology Co-Author(s): Caiden J Walter, Ian A Cleary “Determining the role of the protein encoded by C albicans orf19.2302 in metal stress” 116 Olivia Harlow, Calvin University Microbiology Co-Presenter(s): Ethan Houskamp Co-Author(s): Dr Shannon Manning, Dr Erica Boldenow “Non-hemolytic and hemolytic Group B Streptococcus: interactions with cells in vitro” 117 Curtis Mack, Grand Valley State University Microbiology Co-Author(s): Derek P Thomas, Ian A Cleary “Testing the ancestral function of divergent Candida albicans virulence-associated proteins via expression in Saccharomyces cerevisiae mutants” 118 Jazmine Vasquez, Grand Valley State University Microbiology / Mycology Co-Author(s): Derek P Thomas, Ian A Cleary “Analyzing the role of a protein downregulated early after induction of filamentous growth in Candida albicans” 119 Sidney Weaver, Grand Valley State University Neuroscience Co-Presenter(s): Rebecca DeBaar, Kiley Hassevoort and Aashay Mandala Co-Author(s): John Capodilupo “Can the Phosphorylated Isoform of GAP-43 be a Novel Biomarker for Alzheimer's Disease?” 120 Sofia Hessler, Grand Valley State University Neuroscience Co-Author(s): Dr Merritt DeLano-Taylor “Impact of Phosphomimetic Nato3 Mutants on Midbrain Dopamine Neuron Related Gene Expression” 121 Anna Lunderberg, Hope College Neuroscience Co-Author(s): Dr Leah Chase “Multi-faceted neurochemical analysis of a novel animal model for bipolar disorder” 122 Alice Sorel, University of Michigan - Ann Arbor Neuroscience Co-Author(s): Daniel J Doyle, Kenneth Y Kwan “Overexpression of Actb in Cortical Development” Page 28 of 39 123 Brooke Van Wyk, Hope College Neuroscience Co-Author(s): G.S Fraley, D Shafer, S.M Fraley, P Rivera “Post-hatch Ontogeny of Melanopsin Gene Expression in the Brain of Breeder Ducks” 124 Kalyn Peterson, Grand Valley State University Neuroscience Co-Presenter(s): Leo Gallagher and Erin Reasoner Co-Author(s): Shkelzen Shabani “The aversive effects of methamphetamine are partly mediated through dopamine D2 receptor” 125 Miranda Regenold, Grand Valley State University Neuroscience Co-Presenter(s): Emily Spencer “The Determination of Phosphorylation of Nato3 by PKA Through Newly Generated Flag Epitopes” 126 Alexander Perez, Grand Valley State University Neuroscience Co-Author(s): Dr Eric Ramsson, Alex Ryan, Erdonit Jahaj, Mallory Steffens, Trevor Borgeld, Kirsten Kasche “The Effect of Cannabidiol on Dopamine Release in the Caudate Putamen and Nucleus Accumbens” 127 Gage Paul, Grand Valley State University Neuroscience Co-Presenter(s): Cory Gemmens Co-Author(s): Diego Flores, Mark Cunningham, Sok Kean Khoo “β-synuclein as treatment for Parkinson’s symptoms in Drosophila” 128 Maxwell Okros, Grand Valley State University Neuroscience / Transcriptional Neuroscience Co-Author(s): AUTHOR BLOCK M OKROS1, M FRANTZESKAKIS2, P CHOWDHARY1, *M K DELANO-TAYLOR3; 1Biomed Sci., 2Cell and Mol Biol., 3Grand Valley State Univ., Allendale, MI “Cyclic AMP Dependant Protein Kinase Regulation of Nato3 Induction of Dopamine Neuron Gene Expression” 129 Hannah Long, Grand Valley State University Optometric Practices Co-Author(s): Dr John Capodilupo- Faculty Advisor “Vision Therapy and Autism Spectrum Disorders” 130 Tran Vo, Kalamazoo College Organic Chemistry “Efforts Towards the Synthesis of Aspernigrin A-Melatonin Hybrids” 131 Wentao Dai, Kalamazoo College Organic Chemistry Co-Author(s): Wentao Dai; Dustin Tibbetts; Dr Blakely W Tresca “Investigation of Non-Metallic Supramolecular Photoredox Catalysts for 4-Nitrophenol Reduction” 132 Julia Loula, Hope College Organic Chemistry Co-Author(s): Erik J Schoonover, Jeffrey B Johnson* “Mechanistic Survey of Rhodium-CatalyzedDecarbonylation Reactions: A Kinetics Study” Page 29 of 39 133 Tuba Jaherun, Calvin University Organic Chemistry Co-Presenter(s): Luke Burroughs, Yena Jin Co-Author(s): Nathaneal Kazmeirczak and Dr Michael Barbachyn “Progress Toward the Synthesis of Regioisomeric Aminomethyl-Substituted QPT-1 Bacterial Topoisomerase Inhibitors Luke Burroughs,* Tuba Jaherun,* Yena Jin,* Nathanael Kazmierczak and Dr Michael Barbachyn Calvin College, Department of Chemistry and Biochem” 134 Claire Muckian, Hope College Organic Chemistry Co-Author(s): Constance B Anderson, Gregory S Hedrick, Jonathan Vanden Akker, Jeffrey B Johnson* “Rhodium-Catalyzed Carbon-Carbon Bond Activation Utilizing Removable Amide Directing Groups” 135 Colin Hartgerink, Calvin University Organic Chemistry Co-Presenter(s): Jaimie E Van De Burg Co-Author(s): Dr Carolyn E Anderson “Synthesis of Trisubstituted Indolizines from 2-Propargyloxypyridines” 136 Lu Liu, Kalamazoo College Organic Chemistry Synthesis Co-Author(s): Dr Dwight Williams “Towards The Synthesis of N-Cyclopropyl Quinoline-Caffeic Acid Phenethyl Ester Hybrids As Novel Antibacterials” 137 Christopher Vennard, Kalamazoo College Organic Synthesis Co-Author(s): Dr Dwight Williams, Dr Regina Stevens-Truss, Amelia Brave “Design, Synthesis, and Antibacterial Evaluation of Coumarin-Yanglingmycin Hybrids” 138 Mya Gough, Kalamazoo College Organic Synthesis Co-Author(s): Dr Dwight Williams “Design and Synthesis of Maleimide-Tryptamine Hybrids as Novel Antibacterial Agents” 139 Brock Stenfors, Grand Valley State University Organic Synthesis Co-Author(s): Rachel Collins, Erin Bookout, Felix N Ngassa* “Synthesis of aryl sulfonamides via analogous nucleophilic acyl substitution of p-toluenesulfonyl chloride” 140 Justin Conrad, Indiana Wesleyan University Organic Synthesis Co-Author(s): Dr Stephen Leonard “Synthesis of Bivalent inhibitor for Protein Tyrosine Phosphatase SHP2” 141 Alex Lovins, Indiana Wesleyan University Organic Synthesis Co-Author(s): Advisors: Dr Alexander Seed and Dr Paul Sampson Others: Dr Nikola Brasch (Auckland University of Technology), Michelle Lofink, Will Jencius “Synthesis of New Photoactivatable HNO Donors” Page 30 of 39 142 Zach Farrell, Calvin University Organic Synthesis of Isoquinoline Alkaloids Co-Presenter(s): Thao Tran Co-Author(s): Kaitie Cartwight and Dr Carolyn Anderson “Synthesis of Trisubstituted Isoquinoline Alkaloids” 143 Zoe Stroobosscher, Calvin University Peptide Bonding Co-Presenter(s): Seanna Johnson Co-Author(s): Professor Chad Tatko “Noncovalent Bonding Interactions of Peptides” 144 Matthew Swanson, Ferris State University Pharmacokinetics Co-Author(s): Carlye Szarowicz1, Schuyler T Pike1, Thomas C Dowling2, Chad Shultz3, and André S Bachmann3 “LC-MS/MS Assay to Determine DFMO Concentrations in Mouse Plasma” 145 Yukun Tu, Calvin University Physical Chemistry Co-Author(s): Mark Muyskens “Fluorescent Behavior of Esculetin” 146 Jacob Boza, Western Michigan University Physics “Detection of charged particles using position sensitive scintillator detectors in nuclear physics” 147 Evan Voyles, Kalamazoo College Physics / Virology Co-Author(s): Dr Dave Wilson “Decomposition of Virus eigenmodes into Symmetry-Adapted Spherical Functions (SAFs)” 148 Alyssa Powell, Indiana Wesleyan University Physiology Co-Author(s): Adam Schantz, Brock Goeglein, Thomas Leuschner, Michael Gongwer, Lexi Shepherd, Hannah Caringal, Rachel McKuras, Boriana K Tchernookova, Robert P Malchow, and Matthew A Kreitzer “Role of Calmodulin and PKC in ATP-Induced Acidification of Müller Cells Introduction” 149 Ethan Tippett, Ferris State University Plant Diagnostics Co-Author(s): Dr Washington Luis da Silva “Grapevine Leafroll Disease Study in ‘Cabernet Franc’ Vines at a Connecticut Vineyard” 150 Austin VanDenTop, Grand Valley State University Plant Molecular Biology “Exploring an alternative role for the COP9 Signalosome in the ethylene response pathway” 151 Miguel Castelan Hernandez, Hope College Plasma Physics Co-Author(s): Levi R Smith, G.T Lenters, Z.T Kellner, A.R Medema, and S.K Remillard “Behavioral Regimes of Microplasma at High Frequency” 152 Kimberly Paquette, Hope College Psychology Co-Author(s): Alyssa Cheadle, Jared Ortiz “Disability, Religiousness, & Spirituality” Page 31 of 39 153 Nathan LeFebre, Calvin University Psychology Co-Author(s): Peter Meindl “The Effect of Exemplar Likability on Moral Elevation” 154 Trevor Ditmar, Grand Valley State University Public Health Co-Author(s): Babasola Fateye, Adedipupo King “Examining the Effect of a Hypothetical Safe Injection Facility on HIV and HCV Transmission Rates in Kent County, Michigan” 155 Sean Fleisher, Grand Valley State University Regenerative Properties of Planaria Co-Author(s): Dawn Hart “Regenerative Properties of Planaria” 156 Stellamarie Pobi, Calvin University Science Education Co-Presenter(s): Harold Gee III Co-Author(s): Herb Fynewever “S-STEM Scholars at Calvin University” 157 Oscar Schott, Calvin University Space Systems (Phy / CS / Engr) Co-Author(s): James Newman, Chair - Space Systems Academic Group, Naval Postgraduate School, Monterey CA “Automated Navigation of High Altitude Payload” 158 Henos Tadesse, Calvin University Sustainability Co-Author(s): Professor Jeremy Van Antwerp “Biofuels, Additives and The Road Ahead” 159 KangJin Lee, Calvin University Synthetic Organic Chemistry Co-Author(s): Dr Michael Barbachyn “Preparation of a Novel Trifluoroborate Reagent and Initial Investigations into its Use in Suzuki-Miyaura Cross-Coupling Reactions” 160 Madison Nabozny, Ferris State University Taphonomy Co-Author(s): Dr Susan Stejskal and Dr Bredley Isler “Dead in the Water” 161 POSTER WITHDRAWN 162 Megan Lopez, Hope College Virology Co-Author(s): Christopher Belica and Benjamin G Kopek “Examining the Microenvironment and Lipid Content of Viral Replication Complexes” 163 Andrew Rademacher, Hillsdale College Virology Co-Author(s): Silas Johnson “Low efficiency of CRISPR-Cas9 mediated hnRNP-A1 knockout in NIH-3T3 Cells” Page 32 of 39 INTERNSHIP AND EMPLOYMENT RECRUITER/REPRESENTATIVE CONTACT INFORMATION Internship and employment recruiters/representatives are available in the DEVOS LOBBY GENTEX CORPORATION WEBSITE: http://www.gentex.com/ Gentex Corporation – Corporate Headquarters 600 North Centennial Street Zeeland, MI 49464 Michael Schipper, Talent Acquisition Specialist Email: hr@gentex.com Telephone: 616-772-1800 Kurtis Geerlings, Research Manager Email: hr@gentex.com Telephone: 616-772-1800 Gentex Corporation internship and employment recruiters will be available from 9:00 AM to 3:30 PM VAN ANDEL INSTITUTE RESEARCH INTERNSHIPS: http://vaigs.vai.org/undergrad-research/internship-opps/ GUEST STUDENT OPPORTUNITIES: http://vaigs.vai.org/undergrad-research/ Van Andel Institute 333 Bostwick Ave.NE Grand Rapids, MI 49503 Undergraduate & Internship Program Committee Email: undergrad@vai.edu Telephone: 616-234-5708 Please see Michelle Love at the WMRUGS information desk between 9:00 AM and 3:30 PM for information on internship programs and guest student opportunities Page 33 of 39 GRADUATE SCHOOL, MEDICAL SCHOOL AND PROFESSIONAL MASTER’S PROGRAM RECRUITER CONTACT INFORMATION Graduate school, medical school and professional master’s program recruiters/representatives are available in the DEVOS LOBBY CASE WESTERN RESERVE UNIVERSITY – DEPARTMENT OF CHEMISTRY WEBSITE: http://chemistry.case.edu Department of Chemistry Case Western Reserve University 2080 Adelbert Road Clapp Hall 212 Cleveland, OH 44106 Dr Genevieve Sauve, Associate Professor Email: gxs244@case.edu Telephone: 216-368-3665 Case Western Reserve University – Department of Chemistry recruiters/representatives will be available from 10:00 AM to 2:30 PM FERRIS STATE UNIVERSITY – COLLEGE OF PHARMACY WEBSITE: http://www.ferris.edu/colleges/pharmacy College of Pharmacy Ferris State University Pharmacy Building 220 Ferris Drive Big Rapids, MI 49307 Dr Stephen Durst, Dean – College of Pharmacy, Dean’s Office Email: dursts@ferris.edu Telephone: 231-591-2254 Dr Thomas Dowling, Assistant Dean and Director of Research and Sponsored Programs Email: thomasdowling@ferris.edu Telephone: 616-643-1137 Ferris State University – College of Pharmacy recruiters/representatives will be available from 9:00 AM to 3:30 PM Page 34 of 39 GRADUATE SCHOOL, MEDICAL SCHOOL AND PROFESSIONAL MASTER’S PROGRAM RECRUITER CONTACT INFORMATION Graduate school, medical school and professional master’s program recruiters/representatives are available in the DEVOS LOBBY GRAND VALLEY STATE UNIVERSITY WEBSITE: http://www.gvsu.edu/ Grand Valley State University – The Graduate School 401 W Fulton Street / 318C DEV Grand Rapids, MI 49504 Office of Graduate Studies Website: http://www.gvsu.edu/gs Jennifer Palm, Assistant to the Graduate School Email: palmj@gvsu.edu Telephone: 616-331-6858 Cori Jaskiewicz, Graduate Assistant Email: jaskicor@gvsu.edu Telephone: 616-331-7105 Mark Luttenton, PhD, Associate Dean of the Graduate School Email: luttentm@gvsu.edu Telephone: 616-331-2675 Grand Valley State University – Professional Science Master’s (PSM) 618C Eberhard Center / 301 W Fulton Street Grand Rapids, MI 49504 Professional Science Master’s (PSM) Website: http://www.gvsu.edu/psm/ Tim Born, PhD, Professional Science Master’s Associate Dean Email: bornti@gvsu.edu Telephone: 616-331-8643 Anirudh Chowdhary, PhD, Professional Science Master’s Coordinator Email: chowdhan@gvsu.edu Telephone: 616-331-6297 Grand Valley State University recruiters/representatives will be available from 9:00 AM to 3:30 PM INDIANA UNIVERSITY SCHOOL OF MEDICINE – GRADUATE DIVISION WEBSITE: https://medicine.iu.edu/education/graduate-degrees/phd/indianapolis/ Indiana University School of Medicine – Graduate Division 635 North Barnhill Drive / Room 207 Indianapolis, IN 46202 Brandy Wood, Assistant Director, IBMG Program for PhD Study Email: biomed@iupui.edu Telephone: 317-274-8719 Indiana University School of Medicine – Graduate Division recruiters/representatives will be available from 9:00 AM to 3:30 PM Page 35 of 39 GRADUATE SCHOOL, MEDICAL SCHOOL AND PROFESSIONAL MASTER’S PROGRAM RECRUITER CONTACT INFORMATION Graduate school, medical school and professional master’s program recruiters/representatives are available in the DEVOS LOBBY MANCHESTER UNIVERSITY – COLLEGE OF PHARMACY, NATURAL & HEALTH SCIENCES WEBSITE: www.manchester.edu College of Pharmacy, Natural & Health Sciences Manchester University 10627 Diebold Road Fort Wayne, IN 46845 Julie Cogley-Pifko, Assistant Director of Admissions and Enrollment Management Email: jacogley@manchester.edu Telephone: 260-470-2678 Manchester University – College of Pharmacy, Natural & Health Sciences recruiters/representatives will be available from 9:00 AM to 3:30 PM MICHIGAN STATE UNIVERSITY COLLEGE OF OSTEOPATHIC MEDICINE WEBSITE: http://com.msu.edu/admissions Michigan State University College of Osteopathic Medicine Office of Admissions & Student Life 965 Wilson Road East Fee Hall Room A136 E Lansing, MI 48824 Lorie Culham, Admissions Manager Email: com.admissions@hc.msu.edu Telephone: 517-353-7740 Michigan State University’s College of Osteopathic Medicine recruiters/representatives will be available from 9:00 AM to 3:30 PM OHIO STATE UNIVERSITY, THE – BIOCHEMISTRY PROGRAM WEBSITE: http://osbp.osu.edu Biochemistry Program The Ohio State University 109 Biological Sciences Building 484 W 12th Ave Columbus, OH 43210 Frances Brink, OSBP Program Manager Email: osbp@osu.edu Telephone: 614-292-1463 Ohio State University – Biochemistry Program recruiters/representatives will be available from 9:00 AM to 3:30 PM Page 36 of 39 GRADUATE SCHOOL, MEDICAL SCHOOL AND PROFESSIONAL MASTER’S PROGRAM RECRUITER CONTACT INFORMATION Graduate school, medical school and professional master’s program recruiters/representatives are available in the DEVOS LOBBY PURDUE UNIVERSITY – INTERDISCIPLINARY LIFE SCIENCE PROGRAM (PULSE) WEBSITE: http://www.purdue.edu/gradschool/PULSe Purdue University – Interdisciplinary Life Science Program (PULSe) 155 S Grant Street West Lafayette, IN 47907 Lindsey Springer, Graduate Program Specialist Email: lbcampbe@purdue.edu Telephone: 765-496-9667 Purdue University – Interdisciplinary Life Science Program (PULSe) recruiters/representatives will be available from 9:00 AM to 3:30 PM ST JUDE CHILDREN'S RESEARCH HOSPITAL GRADUATE SCHOOL OF BIOMEDICAL SCIENCES WEBSITE: http://stjude.org/graduate-school Graduate School of Biomedical Sciences St Jude Children's Research Hospital 262 Danny Thomas Place Mailstop 1500 Memphis, TN 38105 Brian Walton, Senior Vice President and Associate Dean Email: brian.walton@stjude.org Telephone: 901-595-1502 St Jude Children's Research Hospital Graduate School of Biomedical Sciences recruiters/representatives will be available from 9:00 AM to 3:30 PM UNIVERSITY OF MICHIGAN – DEPARTMENT OF MOLECULAR & INTEGRATIVE PHYSIOLOGY WEBSITE: https://medicine.umich.edu/dept/molecular-integrative-physiology NCRC Building 26 207S University of Michigan – Department of Molecular & Integrative Physiology 2800 Plymouth Road Ann Arbor, MI 48109 Daniel Michele, Professor and Graduate Program Director Email: dmichele@umich.edu Telephone: 734-764-5738 University of Michigan – Department of Molecular & Integrative Physiology recruiters/representatives will be available from 9:00 AM to 3:30 PM Page 37 of 39 GRADUATE SCHOOL, MEDICAL SCHOOL AND PROFESSIONAL MASTER’S PROGRAM RECRUITER CONTACT INFORMATION Graduate school, medical school and professional master’s program recruiters/representatives are available in the DEVOS LOBBY UNIVERSITY OF MICHIGAN – MICHIGAN MEDICINE – OFFICE OF GRADUATE & POSTDOCTORAL STUDIES WEBSITE: https://medicine.umich.edu/medschool/education Michigan Medicine – Office of Graduate & Postdoctoral Studies University of Michigan 1135 Catherine Street 2960 Tubman Health Sciences Library Ann Arbor, MI 48109 Jim Musgrave, Director of Graduate Enrollment Management Email: jdmusg@med.umich.edu Telephone: 734-615-1581 Michigan Medicine’s Office of Graduate & Postdoctoral Studies recruiters/representatives will be available from 9:00 AM to 3: 30 PM UNIVERSITY OF MICHIGAN – SCHOOL OF PUBLIC HEALTH WEBSITE: http://sph.umich.edu/ School of Public Health University of Michigan 1415 Washington Heights Ann Arbor, MI 48109 Mary Carroll, Assistant Director of Student Affairs Email: maryeli@umich.edu Telephone: 734-764-9554 Kristen McCarthy, Admissions Coordinator Email: kmcca@umich.edu Telephone: 734-763-0931 University of Michigan’s School of Public Health recruiters/representatives will be available from 9:00 AM to 3:30 PM VAN ANDEL INSTITUTE GRADUATE SCHOOL WEBSITE: http://vaigs.vai.org/ Van Andel Institute Graduate School 333 Bostwick Avenue, NE Grand Rapids, MI 49503 Christy Mayo, Enrollment and Records Administrator Email: registrar@vai.edu Telephone: 616-234-5708 Van Andel Institute Graduate School recruiters/representatives will be available from 9:00 AM to 3:30 PM Page 38 of 39 GRADUATE SCHOOL, MEDICAL SCHOOL AND PROFESSIONAL MASTER’S PROGRAM RECRUITER CONTACT INFORMATION Graduate school, medical school and professional master’s program recruiters/representatives are available in the DEVOS LOBBY WESTERN MICHIGAN UNIVERSITY – GRADUATE COLLEGE WEBSITE: https://wmich.edu/grad Graduate College Western Michigan University 1903 W Michigan Avenue Kalamazoo, MI 49008 Tony Dennis, Director of Graduate Student Recruitment Email: tony.dennis@wmich.edu Telephone: 269-387-8212 Western Michigan University Graduate College recruiters/representatives will be available from 9:00 AM to 3:30 PM WESTERN MICHIGAN UNIVERSITY – HOMER STRYKER M.D SCHOOL OF MEDICINE WEBSITE: https://med.wmich.edu Homer Stryker M.D School of Medicine Western Michigan University 300 Portage Street Kalamazoo, MI 49007 Steve McDonald, Assistant Director of Admissions Telephone: 269-337-6100 Email: admissions@med.wmich.edu Dale Vandré, Associate Dean – Research Telephone: 269-337-4400 Email: admissions@med.wmich.edu Western Michigan University Homer Stryker M.D School of Medicine recruiters/representatives will be available from 9:00 AM to 3:00 PM Page 39 of 39