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How to Manage Biomedical Imaging Research Gabriel P Krestin MD, PhD Erasmus MC University Medical Center Rotterdam Challenges in Biomedical Imaging Research  Clinical work is prioritized over, and financially better reworded than research  The deficiency in human resources makes it difficult to satisfy clinical service, teaching, and research missions  Imaging used in clinical trials without involvement of radiologists  Fundamental research with imaging claimed by many  Limited funding for specific imaging research  Funded research does not cover true costs; policy of fund-matching limits growth  Few multidisciplinary research groups Moreover… Many clinicians lack:  Adequate research training  Protected time to: - perform feasibility studies - write (and rewrite) grant applications - conduct research  Culture that values research Don’t Forget that… Research:  Is hard work (not a leisure activity)  Needs investment (nothing is for free)  Is business (generates financial incomes & prestige)  Needs focus (has to achieve goals)  Has to generate output (publications, scientific presentations)  Is a process (has to be managed) Researcher´s Annual Appraisal Case Study  Medical Imaging Research @  Erasmus MC Erasmus MC in Perspective  The Netherlands population: 16,730,000  Rotterdam: harbour city population: 616,000  Erasmus MC: employees: 13,000 Dutch Healthcare: Facts & Figures Total number of Hospitals:  general  university medical center 68 60 Erasmus MC = Largest University Medical Center in the Netherlands from bench to bedside - from patient to population Erasmus MC: Facts & Figures Employees 13,000  Medical and Scientific Staff 1,800  Nursing personnel 2,800 Students 2,950  Medicine 2,400  Health Policy and Management 550 Medical specialist educational programs 28 Total budget € 1,192,608,000 Beds 1,320 Outdoor patients annually 525,000 Elsevier Ranking 2010-2014 Radiology, Nuclear Medicine and Imaging 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 Harvard University Johns Hopkins University University of Toronto University of Pennsylvania Stanford University University of Michigan University of Texas M D Anderson Cancer Center University of California at Los Angeles Duke University Mayo Clinic Rochester MN University of Heidelberg University of Washington University of California at San Francisco University College London Washington University St Louis Seoul National University VA Medical Center University of Wisconsin University of Pittsburgh Utrecht University New York University University of British Columbia Emory University University of Munich Memorial Sloan-Kettering Cancer Center Columbia University Erasmus University Rotterdam University of Zurich Yonsei University Shanghai Jiaotong University University of Erlangen-Nuremberg Medical University of Vienna University of Chicago INSERM Technische Universitat Munchen University of Ulsan Capital University of Medical Sciences Cleveland Clinic Foundation Yale University Universidade de Sao Paulo University of Copenhagen General Electric Sungkyunkwan University Siemens Charite - Universitatsmedizin Berlin University of North Carolina Katholieke Universiteit Leuven University of Amsterdam University of California at San Diego Northwestern University United States United States Canada United States United States United States United States United States United States United States Germany United States United States United Kingdom United States South Korea United States United States United States Netherlands United States Canada United States Germany United States United States Netherlands Switzerland South Korea China Germany Austria United States France Germany South Korea China United States United States Brazil Denmark United States South Korea Germany Germany United States Belgium Netherlands United States United States Number of Publications 4680 2087 2058 1783 1582 1528 1510 1483 1413 1364 1359 1323 1296 1214 1207 1175 1148 1129 1003 982 960 958 949 926 916 882 871 865 860 850 846 822 813 808 806 782 777 772 768 756 753 753 747 737 730 724 722 721 717 708 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 Harvard University University of Toronto Johns Hopkins University University of Texas M D Anderson Cancer Center Stanford University Duke University Mayo Clinic Rochester MN University of California at Los Angeles University of Wisconsin University of Pennsylvania University of Michigan University of California at San Francisco Memorial Sloan-Kettering Cancer Center University College London Washington University St Louis Erasmus University Rotterdam Utrecht University VA Medical Center University of Heidelberg New York University University of Pittsburgh Columbia University University of Erlangen-Nuremberg Cleveland Clinic Foundation University of Zurich University of Washington Technische Universitat Munchen University of Copenhagen Medical University of Vienna University of California at San Diego Seoul National University University of Munich Siemens General Electric Emory University Katholieke Universiteit Leuven University of British Columbia Yale University University of North Carolina University of Amsterdam University of Chicago INSERM Charite - Universitatsmedizin Berlin Northwestern University University of Ulsan Yonsei University Sungkyunkwan University Universidade de Sao Paulo Shanghai Jiaotong University Capital University of Medical Sciences United States Canada United States United States United States United States United States United States United States United States United States United States United States United Kingdom United States Netherlands Netherlands United States Germany United States United States United States Germany United States Switzerland United States Germany Denmark Austria United States South Korea Germany Germany United States United States Belgium Canada United States United States Netherlands United States France Germany United States South Korea South Korea South Korea Brazil China China Number of Citations 30826 12274 12210 11554 10942 10090 9986 9528 9521 9466 9176 8677 8124 7998 7622 7470 7253 6959 6878 6667 6168 6091 6048 5946 5842 5825 5808 5776 5696 5694 5682 5660 5440 5428 5298 5204 5175 5092 5028 4947 4780 4513 4336 4280 4153 3630 3511 2679 2078 1608 Elsevier Ranking 2010-2014 Radiology, Nuclear Medicine and Imaging 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 Memorial Sloan-Kettering Cancer Center Erasmus University Rotterdam University of Wisconsin University of California at San Diego University of Texas M D Anderson Cancer Center Cleveland Clinic Foundation University of Copenhagen Utrecht University Siemens Mayo Clinic Rochester MN Technische Universitat Munchen General Electric Katholieke Universiteit Leuven Duke University University of Erlangen-Nuremberg Stanford University New York University Columbia University Medical University of Vienna University of North Carolina University of Amsterdam University of Zurich University of California at San Francisco Harvard University University College London Yale University University of California at Los Angeles Washington University St Louis VA Medical Center University of Pittsburgh University of Munich University of Toronto University of Michigan Northwestern University Johns Hopkins University University of Chicago Charite - Universitatsmedizin Berlin Emory University INSERM University of British Columbia University of Pennsylvania University of Ulsan University of Heidelberg Seoul National University Sungkyunkwan University University of Washington Yonsei University Universidade de Sao Paulo Shanghai Jiaotong University Capital University of Medical Sciences United States Netherlands United States United States United States United States Denmark Netherlands Germany United States Germany United States Belgium United States Germany United States United States United States Austria United States Netherlands Switzerland United States United States United Kingdom United States United States United States United States United States Germany Canada United States United States United States United States Germany United States France Canada United States South Korea Germany South Korea South Korea United States South Korea Brazil China China Citations / Publication 8,9 8,6 8,4 7,9 7,7 7,7 7,7 7,4 7,4 7,3 7,2 7,2 7,2 7,1 7,1 6,9 6,9 6,9 6,9 6,9 6,9 6,8 6,7 6,6 6,6 6,6 6,4 6,3 6,1 6,1 6,1 6 5,9 5,9 5,9 5,6 5,6 5,4 5,3 5,3 5,1 4,8 4,7 4,4 4,2 3,5 2,4 2,1 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 University College London Erasmus University Rotterdam Utrecht University Memorial Sloan-Kettering Cancer Center University of Copenhagen Siemens Yale University University of Erlangen-Nuremberg University of California at San Diego University of California at Los Angeles Columbia University Katholieke Universiteit Leuven University of Wisconsin Emory University Technische Universitat Munchen Cleveland Clinic Foundation University of Zurich General Electric Duke University Mayo Clinic Rochester MN University of Amsterdam Charite - Universitatsmedizin Berlin Harvard University Johns Hopkins University University of Pennsylvania Stanford University Northwestern University New York University University of Pittsburgh Medical University of Vienna University of North Carolina University of California at San Francisco University of Munich University of Texas M D Anderson Cancer Center Washington University St Louis University of Michigan VA Medical Center University of Chicago University of Heidelberg University of British Columbia University of Toronto INSERM University of Washington Seoul National University University of Ulsan Sungkyunkwan University Universidade de Sao Paulo Yonsei University Shanghai Jiaotong University Capital University of Medical Sciences UK Netherlands Netherlands United States Denmark Germany United States Germany United States United States United States Belgium United States United States Germany United States Switzerland United States United States United States Netherlands Germany United States United States United States United States United States United States United States Austria United States United States Germany United States United States United States United States United States Germany Canada Canada France United States South Korea South Korea South Korea Brazil South Korea China China 2,26 2,15 1,97 1,96 1,95 1,9 1,85 1,83 1,83 1,79 1,78 1,77 1,76 1,74 1,74 1,73 1,71 1,7 1,69 1,69 1,67 1,63 1,62 1,62 1,61 1,61 1,61 1,6 1,59 1,56 1,56 1,53 1,53 1,51 1,49 1,48 1,47 1,44 1,42 1,42 1,38 1,36 1,18 1,14 1,12 1,12 1,11 0,96 0,63 0,43 Field-Weighted Citation Impact Key Elements to Consider  Strategy  Collaboration (internal, institutional, external)  Diversity and focus  Support/administration  Infrastructure  Monitoring performance Research Needs: PEOPLE MONEY Research Culture IDEAS Start Small Why ?  If you start small, you still have the option to become BIG later  Avoid temptation to conquer all frontiers – it could be too much  Small means manageable and easy  Small means flexible  Can redirect goals and effort as times change  Small grants are often a good start  Small means fewer people to support (fewer mouths to feed) Smaller budget Less scary Sleep better at night  Small means FUN Chaos Strategic Plan Ideas Strategic Plan Goals Vision Strategic Planning VISION G O A L S STRATEGIC PLAN ORGANIZATIONAL STRUCTURE MONITORING RESULTS Monitoring the Research Process INPUTS ACTIVITIES OUTPUTS Organizational Structure of Radiology Research at Erasmus MC MOLECULAR IMAGING FUNDAMENTAL PHYSICS & TECHNOLOGY DEV IMAGE ANALYSIS CLINICAL DIAGNOSTICS THERAPY EPIDEMIOLOGIC POPULATION MODELLING & IMAGING ASSESSMENT INTERVENTIONS MRI Main Programms CT = Technolologies PIs in Rad & Nu.med Research Infrastructure  Equipment  Space  Support personnel - technicians (perform research exams, over standard knowledge) - trial nurses (perform clinical trials, interface with patients) - animal handlers - data manager, biostatistician (study design, data analysis) - “grant-hunter” - grant manager (accountant) - graphic designer - medical writer  A research infrastructure not only facilitates research, but also contributes to the culture  “Culture in which research is valued” Research Management Solutions for Radiology Departments  Create “culture in which research is valued”  Start small  Identify and support collaborations  Provide research infrastructure improve investigator efficiency improve job satisfaction of investigator  Develop a strategic plan clearly define goals create a structure  Define and monitor processes use input, throughput, and output metrics use research MIS And Then….? S.A Tartakower, Russian chess master “The mistakes are all there waiting to be made.” Thank You for Your Attention

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