Research Team Eric Arnold, Ph.D Principal Investigator Assistant Professor Department of Health Sciences and Human Performance The University of Tampa Gregory L Burns, DHSC, PA-C Co-Principal Investigator Associate Professor and Academic Director Department of Physician Assistant Medicine The University of Tampa Departments of Health Sciences and Human Performance and Physician Assistant Medicine Chrisoula Kiriazis, M.D Co-Principal Investigator Director of Diabetes Prevention Baycare Health System Kimberly Mularoni, M.D., FAAP Co-Principal Investigator Assistant Professor and Medical Director Department of Physician Assistant Medicine The University of Tampa Nauris Tamulevicius, Ph.D., EP-C Co-Principal Investigator Associate Professor Department of Health Sciences and Human Performance The University of Tampa Janice C Zgibor, R.Ph., Ph.D Co-Principal Investigator Professor Director, Doctoral Program in Epidemiology and COPH Doctor of Public Health Program Department of Epidemiology and Biostatistics University of South Florida UT-IRB Approved Study: 18-051 An Exercise Program Comparing 1heUnirersityOf High-Intensity Interval Exercise Training to Moderate-Intensity Continuous Exercise Training To submit your recommendation or for more information contact Eric Arnold, Ph.D Assistant Professor Department of Health Sciences and Human Performance College of Natural and Health Sciences The University of Tampa Cell: (404) 977-7684 Office: (813) 257-3554 Fax: (813) 258-7482 cearnold@ut.edu on the Metabolic Profle in Prediabetes Patients www.ut.edu Purpose To determine if participating in three months of high-intensity interval exercise training (HIIT) results in a greater improvement in the metabolic profle (see assessments) compared to three months of moderate-intensity continuous exercise training (MICT) HIIT/MICT Exercise Program • Location: Tampa Riverwalk • Exercise Training Duration: months • Frequency: days per week • Exercise Intensity: will be determined prior to beginning exercise session I and adjusted throughout the 3-month study period • Exercise Session Duration: HIIT: 20 minutes of exercise (10 x high-intensity exercise followed by light active recovery between each interval) with 3- to 5-minute warm-up and cool-down periods Number of intervals will progress from during Week One to 10 intervals by Week Five MICT: Fifty minutes of moderate-intensity exercise per session with 3- to 5-minute warm-up and cool-down periods Exercise session duration will progress from 10 minutes during Week One to 50 minutes by Week Five Assessments The following assessments will be performed before and after the three-month study period at no cost to the participant • Metabolic Profle: A two-hour oral glucose tolerance test, along with blood collection for HbA1c and lipids (TC, HDL-C, LDL-C, and TG) will be performed at LabCorp (5610 W LaSalle St., Tampa) by a certifed phlebotomist • Maximal Aerobic Capacity: A continuous incremental maximal exercise treadmill test will be performed in the Human Performance Laboratory at The University of Tampa to determine VO2max (Fitness Level) • Dual X-Ray Absorptiometry (DEXA) will be performed in the Human Performance Laboratory at The University of Tampa to assess body composition • International Physical Activity, Physical Activity Enjoyment Scale and other questionnaires along with Nutritional Analysis Intake will be performed in the Human Performance Laboratory at The University of Tampa Assessment Technology Recommendation Form Research participants will be • Male and Female, 18–60 years of age • Sedentary, e.g., participating in less than two 30-minute bouts of moderate intensity (walking for pleasure) per week over the past six months • Body Mass Index ≥25 to ≤35 • No previous type or type diabetes • Diagnosis of prediabetes within the past year (check one or more) ❑ Fasting plasma glucose 100–125 mg/dL ❑ HbA1c 5.7%–6.4% ❑ Two-hour plasma glucose (after a 75-gram glucose load) of 140–199 mg/dL Participants will be randomly assigned to the HIIT, MICT or Control Group All participants will receive pre- and post-assessments and group educational sessions Control group will have the opportunity to participate in the exercise program at the end of the 3-month study period Physician Signature ⇐ • Research Personnel Monitoring: Monitored during Months One–Two and exercise independently during Month Three DEXA Physician Name Physician Office Address Physician Office Phone • Exercise Intensity Monitoring: Polar Heart Rate Monitor and Actigraph Accelerometer Patient Signature • Additional Monitoring: Blood pressure and blood glucose before and after each HIIT and MICT exercise session Patient Name • Group Educational Sessions: Four one-hour sessions over the three-month period in a University of Tampa classroom with a licensed psychologist, Sheriece Sadberry, Ph.D., L.P., CMPC Date Date • VO2max⇒ Patient Phone Number Fax this form to Eric Arnold at (813) 258-7482 or Email to cearnold@ut.edu; questions call (404) 977-7684