The cost effectiveness of first trimester screening and early preventative use of aspirin in women at high risk of early onset pre eclampsia Cost of pre eclampsia A cc ep te d A rti cl e The cost effe.
Accepted Article The cost-effectiveness of first trimester screening and early preventative use of aspirin in women at high risk of early onset pre-eclampsia Short Title: Cost of pre-eclampsia Authors: Dayne Ortved1*, T Lee-Ann Hawkins2, Jo-Ann Johnson2, Jon Hyett3, Amy Metcalfe2 1) (*Corresponding Author) Dayne Ortved Royal Inland Hospital and University of British Columbia, Department of Medicine, Kamloops, BC, Canada 311 Columbia Street Kamloops, BC V2C2T1 Email: Dayne.Ortved@interiorhealth.ca 2) University of Calgary, Department of Medicine and Obstetrics & Gynecology, Calgary, Alberta, Canada 3) Central Clinical School, Faculty of Medicine, University of Sydney, NSW, Australia RPA Women and Babies, Royal Prince Alfred Hospital, Sydney, NSW, Australia Keywords: early onset preeclampsia, aspirin, cost-effectiveness, first trimester screening ABSTRACT Objective: Pre-eclampsia (PE) remains a leading cause of maternal and fetal morbidity and mortality A first trimester screening algorithm predicting the risk of This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record Please cite this article as doi: 10.1002/uog.19076 This article is protected by copyright All rights reserved early onset PE has been developed and validated Early prediction coupled with initiation of aspirin at 11 to 13 weeks in women identified as high risk is effective at Accepted Article reducing the prevalence of early onset PE The aim of this study is to evaluate the cost-effectiveness of this first trimester screening program coupled with early use of low-dose aspirin in women at high risk of developing early onset PE versus current practice Methods: A decision analysis was performed based on a theoretical population of live births in Canada in one year (n=387,516) The clinical and financial impact of early preventative screening using the Fetal Medicine Foundation (FMF) algorithm for prediction of early onset PE coupled with early (