[discussion 751–752] 267 van der Linden J, Ekroth R, Lincoln C, et al Is cerebral blood flow/metabolic mismatch during rewarming a risk factor after profound hypothermic procedures in small children? Eur J Cardiothorac Surg 1989;3(3):209–215 268 Hoffman WE, Charbel FT, Edelman G, Ausman JI Thiopental and desflurane treatment for brain protection Neurosurgery 1998;43(5):1050– 1053 269 Fujibayashi T, Sugiura Y, Yanagimoto M, Harada J, Goto Y Brain energy metabolism and blood flow during sevoflurane and halothane anesthesia: effects of hypocapnia and blood pressure fluctuations Acta Anaesthesiol Scand 1993;37(8):806–810 270 Hansen TD, Warner DS, Todd MM, Vust LJ The role of cerebral metabolism in determining the local cerebral blood flow effects of volatile anesthetics: evidence for persistent flowmetabolism coupling J Cereb Blood Flow Metab 1989;9(3):323–328 271 Kaieda R, Todd MM, Warner DS The effects of anesthetics and PaCO2 on the cerebrovascular, metabolic, and electroencephalographic responses to nitrous oxide in the rabbit Anesth Analg 1989;68(2):135–143 272 Hindman BJ, Dexter F, Cutkomp J, et al Brain blood flow and metabolism do not decrease at stable brain temperature during cardiopulmonary bypass in rabbits Anesthesiology 1992;77(2):342–350 273 Holmstrom A, Rosen I, Akeson J Desflurane results in higher cerebral blood flow than sevoflurane or isoflurane at hypocapnia in pigs Acta Anaesthesiol Scand 2004;48(4):400–404 274 Anand KJ, Hickey PR Halothane-morphine compared with high-dose sufentanil for anesthesia and postoperative analgesia in neonatal cardiac surgery N Engl J Med 1992;326(1):1–9 275 Bickler PE, Fahlman CS The inhaled anesthetic, isoflurane, enhances Ca2+-dependent survival signaling in cortical neurons and modulates MAP kinases, apoptosis proteins and transcription factors during hypoxia Anesth Analg 2006;103(2):419–429 [table of contents] 276 Soriano SG, Anand KJ Anesthetics and brain toxicity Curr Opin Anaesthesiol 2005;18(3):293–297 277 Kurth CD, Priestley M, Watzman HM, McCann J, Golden J Desflurane confers neurologic protection for deep hypothermic circulatory arrest in newborn pigs Anesthesiology 2001;95(4):959–964 278 Bissonnette B Cerebral protection Paediatr Anaesth 2004;14(5):403–406 279 Ferriero DM Neonatal brain injury N Engl J Med 2004;351(19):1985–1995 280 McClaine RJ, Uemura K, de la Fuente SG, et al General anesthesia improves fetal cerebral oxygenation without evidence of subsequent neuronal injury J Cereb Blood Flow Metab 2005;25(8):1060–1069 281 McAuliffe JJ, Joseph B, Vorhees CV Isofluranedelayed preconditioning reduces immediate mortality and improves striatal function in adult mice after neonatal hypoxia-ischemia Anesth Analg 2007;104(5):1066–1077 [tables of contents] 282 Ditsworth D, Priestley MA, Loepke AW, et al Apoptotic neuronal death following deep hypothermic circulatory arrest in piglets Anesthesiology 2003;98(5):1119–1127 283 Istaphanous GK, Ward CG, Nan X, et al Characterization and quantification of isoflurane-induced developmental apoptotic cell death in mouse cerebral cortex Anesth Analg 2013;116(4):845–854 284 Harukuni I, Bhardwaj A Mechanisms of brain injury after global cerebral ischemia Neurol