Tài liệu Color Atlas of Pharmacology (Part 3): Distribution in the Body docx

... cells. (Vertical bars in the EM micro- graphs represent 1 µm; E: cross-sec- tioned erythrocyte; AM: actomyosin; G: insulin-containing granules.) 24 Distribution in the Body Lüllmann, Color Atlas of Pharmacology ... Modes of Drug Distribution Following its uptake into the body, the drug is distributed in the blood (1) and through it to the various tissues of...

Ngày tải lên: 22/01/2014, 00:20

... by mechlor- ethamine Insertion of daunorubicin, doxorubicin, bleomycin, actinomycin D, etc. Streptomyces bacteria Inhibition of nucleotide synthesis Purines Thymine Nucleotide Tetrahydro- folate Dihydrofolate Reductase Folic ... receptor that inhibits the phosphatase calcineurin. The latter plays a key role in T-cell signal trans- duction. It contributes to the induction of cyto...

Ngày tải lên: 15/12/2013, 13:15

... as- sessment of the relevant drugs, in keep- ing with the patient’s individual needs. In instituting single-drug therapy (monotherapy), the following consider- ations apply: β-blockers (p. 92) are of value ... are prevented. The most common adverse effects of colchicine are abdominal pain, vomiting, and diarrhea, probably due to inhibition of mitoses in the rapidly di-...

Ngày tải lên: 15/12/2013, 13:15

... Hexa-Betalin, Pyroxine Pyrimethamine Daraprim Pyrimethamine + Sulfadoxine Fansidar Q Quazepam Doral Quinacrine Atabrine Quinapril Accupril Quinidine Cardioqin, Cin-Quin, Quinalan, Quinidex, Quinora Quinine ... Imipramine Imuran Azathioprine Imurek Azathioprine Inapsine Droperidol Inderal Propranolol Indocid Indomethacin Indocin Indomethacin Indome Indomethacin Inflamase Prednisolonechnisolove...

Ngày tải lên: 15/12/2013, 13:15

... substances of plant origin) including: morphine, codeine, narcotine = noscapine, papaverine, nar- ceine, and others. Using a natural product or extract to treat a disease thus usually entails the administration ... la- boratories. The aims of isolating active principles are: 1. Identification of the active ingredi- ent(s). 2. Analysis of the biological effects (pharmacodynamic...

Ngày tải lên: 22/01/2014, 00:20

... spontaneously into a bilayer in an aqueous medium, their polar heads directed outwards into the aqueous medium, the fatty acid chains facing each other and projecting into the inside of the membrane (3). The ... device in front of the mouth, the size of aerosol particles, and the coordi- nation between opening of the spray valve and inspiration. The size of a...

Ngày tải lên: 22/01/2014, 00:20

... accelerated biotransformation, not only of the in- ducing agent but also of other drugs (a form of drug interaction). With contin- ued exposure, induction develops in a few days, resulting in an increase in re- action ... are involved in the conjugation of the amino acids glycine or glutamine with carboxylic acids. In these cases, an amide bond is formed between the...

Ngày tải lên: 22/01/2014, 00:20

... clearance, the shorter is the half-life. In the case of drugs renally elimi- nated in unchanged form, the half-life of elimination can be calculated from the cumulative excretion in urine; the final total ... still present in the body, i.e., the drug accumulates. The shorter the dosing interval relative to the elimination half-life, the larger will be the...

Ngày tải lên: 26/01/2014, 19:20

... ligands, the kinetics of inter- action, and the characteristics of the binding site itself. In studying the affinity and number of such binding sites, use is made of membrane suspensions of different ... decreases and the increment in binding is no longer proportional to the increase in concentration (in the ex- ample illustrated, an increase in con- centratio...

Ngày tải lên: 26/01/2014, 19:20

... induces a change in the conformation of the receptor pro- tein, enabling the latter to interact with a G-protein (= guanyl nucleotide-bind- ing protein). G-proteins lie at the inner leaf of the ... acid are found in the cytosol and in the cell nucleus, respec- tively. Binding of hormone exposes a nor- mally hidden domain of the receptor protein, thereby permittin...

Ngày tải lên: 26/01/2014, 19:20