Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 8B) pdf
Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 8B) pdf
... by the pressure limitationof the HPLC equipment. For more information on gradient separation anddeveloping fast HPLC methods, see Chapter 17 and Practical HPLC MethodDevelopment from Synder ... 0.2- or 0.45-µm-pore-sizefilter is generally recommend for removal of particulates [15]. Filtration as apreventive maintenance tool for HPLC analyses is well-documented in the lit-erature [16–18].Sample ... respective ana-lytical method that is applied to a real in-process sample or a dosage form for subsequent HPLC analysis. The analytical procedure must specify the manu-facturer, type of filter,...
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Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 8C) pdf
... The experiments for wwpH 2–4 were performed on day1, and those for wwpH 5–7 were performed on day 2 (≈36 hr after initial prepa-ration).A further investigation was performed by preparing ... height) for peak B ≤ 1.5•Tailing factor (5% peak height) for peak A ≤ 1.5•Rt for peak A must be 12.0 ± 1.3 min•Rt for peak B must be 21 ± 1.0 min•The S/N of the LOQ solution (0.05%) for both ... down the right path for initial mobile-phase pH selection.In the following case study for this pharmaceutical compound M, themethod development scenario and rationale for each iteration in...
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Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 8D) pdf
... down the right path for initial mobile-phase pH selection.In the following case study for this pharmaceutical compound M, themethod development scenario and rationale for each iteration in ... Figure 8-40A for thesample stored in the acidic diluent for 4 days at room temperature shows somedegradation compared to Figure 8-40B for the sample stored in the acidicdiluent for one day ... departments of most pharmaceutical companies, can be used for thispurpose. Mass spectra should be taken across the peak (−5%, apex, and +5%)as with the PDA. This was performed for Product M, and...
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Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 4B) pdf
... thebasic analyte in its fully neutral form.192 REVERSED-PHASE HPLC Step 1. First, account for the downward pKashift for the basic analyte uponaddition of organic. For every 10 v/v% increase in acetonitrile, ... Similar parameters have been determined for this family of compounds for methanol/water mixtures [80]. Using theseparameters for each family of compounds for a particular type of organic, theasand ... obtain the basic analytein its fully ionized form?Step 1. First account for the downward pKashift for the basic analyte uponaddition of organic. For every 10 v/v% increase in acetonitrile,...
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Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 4C) pdf
... RP HPLC. We hope that it will be useful for practical chro-matographers in their efforts to develop efficient and selective separationmethods, and we also hope that it will be encouraging for ... properties. For acetonitrile/water systems it was found that acetonitrile forms thickadsorbed layer on the surface of hydrophobic bonded phase, while methanoladsorption from water formed a classical ... Horvath [161] and Sokolovski [162, 163] in the form of stochiometricadsorption of ionic species and by Stählberg in the form of adsorption of ionsand formation of an electrical double layer [164].The...
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Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 5) pdf
... decreases, retention in normal-phase chromatography241 HPLC for Pharmaceutical Scientists, Edited by Yuri Kazakevich and Rosario LoBruttoCopyright © 2007 by John Wiley & Sons, Inc.proved to be ... 5NORMAL-PHASE HPLC Yong Liu and Anant Vailaya5.1 INTRODUCTIONHigh-performance liquid chromatography (HPLC) is a separation tool parexcellence for the analysis of compounds ... application that demonstrates the advantages of using NPC for theseparation of analytes prone to hydrolysis is the reaction monitoring for theformation of 9,10-anthraquinone [29]. Anthraquinone is...
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Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 11) pdf
... (i.e., spanning target identification → chemical535 HPLC for Pharmaceutical Scientists, Edited by Yuri Kazakevich and Rosario LoBruttoCopyright © 2007 by John Wiley & Sons, Inc.while maintaining ... chemist to perform high-throughput purification.Although HPLC has long been a method available tothe chemist for product purification, only recently have these systems beendesigned for unattended ... chro-matographic peaks for a given sample will be hard to predict, and thereforethe footprint for fraction collection will be difficult to predict. Experience hasshown that it is not uncommon for 5–10 fractions...
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Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 18) pdf
... in pharmaceutical analysis. The precise and accurate control of temperature can improve repro-ducibility and method transferability (Section 18.2). In recent years, the use of811 HPLC for Pharmaceutical ... eluent for reversed-phase high performance liquid chromatography, Anal. Commun. 33 (1996),327–329.57. R. M. Smith and R. J. Burgess, Superheated water as an eluent for reversed-phasehigh performance ... S. Bowadt, and A. Boenke, The method dependentcertification of an high performance liquid chromatography (HPLC) column for its shape selectivity, hydrophobicity and ion exchange activity,Certification...
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Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 20) pdf
... manufacturing in the pharmaceutical industry. The HPLC (or LC) and MS(LC-MS) or NMR (LC-NMR) interface increases the capability of solving901 HPLC for Pharmaceutical Scientists, Edited by ... operation for LC-NMR (Section20.3.2), with the use of shielded cryomagnets, the location of the MS instru-ment will follow the same rule as for the HPLC. The most common modes ofoperation for LC-MS-NMR ... Reversed-phase HPLC of the sampleswas carried out on a Varian modular HPLC system (a 9012 pump and a 9065photodiode array UV detector).The Varian HPLC software was also equippedwith the capability for...
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Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 7A) pptx
... ions on the basis of mass-to-charge ratios,281 HPLC for Pharmaceutical Scientists, Edited by Yuri Kazakevich and Rosario LoBruttoCopyright © 2007 by John Wiley & Sons, Inc.low-polarity ... the most widely used systems for analysis of large bio-molecules. For a continuous ion source, the ions can be stored for a shortperiod of time and pulsed out for analysis. In the case of ESI, ... structures of analytes. For basic compounds (i.e., amines), apositive ion mode can be used to form a protonated or cationized molecule. For acidic compounds, a deprotonated molecule is formed in the negative...
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