... eitherby presaturation for COSY and TOCSY experiments or using the WATERGATE pulse sequence [21] for NOESYexperiments. A new series of TOCSY and NOESY spectrain D2O was also recorded at ... structure clearlydisplays (a) an hydrophobic face formed by a largeaggregate of hydrophobic residues (Leu5, Tyr7, Val12,and T yr14) w hich are located on the concave surface of t hepeptide; ... of PG-1 isparticularly hydrophobic as it contains only a polar residuesLeu5, Cys6, Tyr7, Cys8, Phe12, Cys13, Val14, Cys15 andVal16 alternatively distributed on each side of the b sheet[9,10]....