Báo cáo y học: "Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects"

... rights reserved Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects Research ... as the evaluation of methylenetetrahdrofolate reductase gene mutation in Egyptian patients with coronary heart disease; evaluation of the clinical utility of procalcitonin in tonsilopharingitis ... Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet. 1996;58(1):35-41....

Báo cáo y học: "Weight loss, leukopenia and thrombocytopenia associated with sustained virologic response to Hepatitis C treatmen"

... prevent physicians from continuing their patients on interferon therapy or reducing dosage (28, 29). A comparison of outcome by the approach of re-ducing interferon and/or ribavirin versus use of growth ... combined pegylated interferon alfa-2a or alfa-2b plus ribavirin. Genotypes of HCV were defined using the Bayer TRUGENE HCV Genotyping Test. Serum concentra-tion of HCV RNA was determined shortly ... (57%) with the mean age of 52.5 years (Table 1). Fifty six percent were infected with genotype 1, 16% with genotype 2 and 28% with genotype 3. Clinical char-acteristics, relevant laboratory data...

Tài liệu Báo cáo Y học: Ornithine decarboxylase-antizyme is rapidly degraded through a mechanism that requires functional ubiquitin-dependent proteolytic activity pot

... precursors. In this biosynthesispathway ornithine is decarboxylated to form putrescine by the action of ornithine decarboxylase (ODC, EC 4.1.1.17).Next an aminopropyl group generated by the action of S-adenosylmethionine ... illumination.RESULTSAntizyme is rapidly degraded by the action of the 26S proteasomeWhile it is clear that interaction with antizyme is requiredfor the degradation of ODC, the cellular fate of antizymeduring this ... practically undetec-ted. These results strongly support the alternative possibilitythat the degradation of antizyme is independent from that of ODC. Further in supporting this possibility is the observation...

Báo cáo Y học: DAP kinase activity is critical for C2-ceramide-induced apoptosis in PC12 cells ppt

... (pro line 277 to leucine 323) containing the calmodulin-binding domain. In the K42A-DK mutant, a lysine residue at position 42 in t he kinase domain (asterisk) is replaced by an a lanine. The D ... kinase [20±22], a lso phosphorylates the regulatorylight chain of myosin II the phosphorylation sites beingthreonine 18 and serine 1 9 [22]. In this study, the syntheticpeptide, skeletal myosin ... as the catalytic domain of DAP kinase is highly h omologous to that of MLC kinase.Zipper-interacting protein kinase (ZIP kinase), with asequence 81% identical to that of the kinase domain of DAP...

Báo cáo Y học: Soluble guanylate cyclase is allosterically inhibited by direct interaction with 2-substituted adenine nucleotides doc

... andcatalytic domains of pGCs is mediated by the KHD in the cytoplasm, which serves as a constitutive repressor of the catalytic domain. This domain contains the 11 subdomainscharacteristic of protein ... C1–C2interface of the catalytic domain of adenylate cyclase do notexist in guanylate cyclases. Thus, the site of adeninenucleotide binding and allosteric regulation in guanylatecyclases remains ... working hypothesis suggests that the KHD is intrinsically inhibitory and ligand–receptorinteraction permits association of that domain with ATPresulting in derepression of the catalytic domain [9–11]....

Báo cáo Y học: ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3) pdf

... phase progression is regulated by G1 cyclinand cyclin-dependent kinases (cdks). Cdk4 or cdk6 is associated with D-type cyclins while cdk2 binds to cyclin Eor cyclin A to become an independent and ... phosphorylated by cyclin A/cdk2, cyclin E/cdk2,cyclin A/cdk3 or cyclin E/cdk3 which is produced in the baculoviral systemWe initially tested a hypothesis that p70ik3-1might be aregulatory cyclin for ... wild-type cdk3, notcdk3 dn, were expressed, supporting the theory that cyclin/cdk3 actually phosphorylates ik3-1.P70ik3-1 is phosphorylated by either cyclin A/cdk3 orcyclin E/cdk3 in vivoFurthermore,...

Báo cáo y học: " A Practical Approach to Managing Patients with HCV Infection"

... identify the possible timing of the infection or the duration of the liver disease include: prior history of injection drug use, former history of transfusion of blood products, unexplained history ... thoroughly reviewed by Drs. Chen and Morgan in this issue. Knowing the natural history of HCV infection is important in the management of patients with chronic HCV infection. Unfortunately, the ... categories of patients: those in whom therapy is widely accepted, those in whom therapy should be individualized and, those in whom therapy is contraindicated [32]. Based on these guidelines, therapy is...

Báo cáo y học: "TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders"

... receptors Introduction One of the clinical challenges in chronic mye-loproliferative disorders (MPD) is thrombocythemia, always present in essential thrombocythemia (ET) and often in polycythemia ... thereby reducing megakaryocyte size and ploidy, and disrupting or preventing full megakaryocyte matura-tion. However, little is known of the interaction of anagrelide with cytokines regulating ... Published: 2008.04.13 Anagrelide is often used in the treatment of thrombocythemia in myeloproliferative disease (MPD), but infor-mation concerning effects of treatment on cytokines involved in...

Báo cáo Y học: Matrilysin (matrix metalloprotease-7) cleaves membrane-bound annexin II and enhances binding of tissue-type plasminogen activator to cancer cell surfaces docx

... Serotonin (5-hydroxytryptamine) interacts with N-acetylneuraminic acid, which is often contained in glycolipids and glycoproteins on the cell surface[24]. We examined the synergistic effects of ... Pannekoek H(1986) On the interaction of the ﬁnger and the krin-gle-2 domain of tissue-type plasminogen activator with ﬁbrin. Inhibition of kringle-2 binding to ﬁbrin byepsilon-amino caproic acid. ... activates the proforms of these MMPs by producing plasmin[47]. Thus, the cleavage of annexin II by matrilysinmay trigger the proteinase ampliﬁcation cascade orcycling in the pericellular space of cancer...

Báo cáo Y học: Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N1,N11-diethylnorspermine pdf

... pools of putres-cine, spermidine and spermine by down-regulating the activity of the polyamine biosynthetic enzymes a nd up-regu-lating the activity of the catabolic enzyme spermidine/spermine ... analysis. Th e cells weresonicatedin50mMTris/HCl (pH 7.5) containing 0.25Msucrose. The a ctivity of SSAT in the sonicate was deter-mined by measuring the synthesis of [14C]acetylspermidineafter ... polyamines has been studied by the use of different biosynthesis inhibitors [1,6]. A d isadvantage of using t hese inhibitors alone is that they usually fail todeplete the cells of all three polyamines....

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