... in the n-Src mutant Y535FD1)258, from which the N-terminus and both the SH3 and SH2 domains were deleted(Fig. S1).To confirm the effect of the SH3 and ⁄ or SH2domain dysfunctions, n-Src and ... activity-dependent, and dysfunctions of the SH2 and ⁄ or SH3 domains do not significantlyaffect the binding. These data indicate that the SH2 and SH3 domains mayfunction to promote the catalytic activity ... of the phosphorylatedC-terminus to the SH2 domain and ⁄ or binding of the SH2 kinase linker to the SH3 domain, lock the molecules in a closed conformation, disrupt the kinase active site, and...