Báo cáo y học: "Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain"

... feasibility of treating neuropathic pain by inhibiting TLR4. Our results demonstrated that in- trathecal siRNA- mediated suppression of TLR4 attenuated CCI-induced mechanical allodynia and thermal ... suppression of TLR4 mediated by intrathecally administered siRNA may be a new strategy for the treatment of neuropathic pain. Key words: Toll-like receptor 4; neuropat...

Ngày tải lên: 25/10/2012, 11:48

... University of Greifswald, Greifswald, Germany.7CentralHospital of Augsburg, MONICA/KORA Myocardial Infarction Registry,Augsburg, Germany.8Ludwig-Maximilians-University, Institute of MedicalData Management, ... 1999 and 2001. A total sample of 6 640 subjectswas drawn from the target population consisting of allGerman residents of the region aged 25 to 74 years .Of all 42 61 pa...

Ngày tải lên: 25/10/2012, 10:45

... chain of arginine residue at 30 of one of the two chains to form a weak salt bridge, thereby causing a slightly increased oxygen affinity. Conflict of interests The authors have declared that ... Meerut, Utlar Pradesh, India [1] and in two brothers from Bangladesh living in Birmingham, England [2]; subsequently the same abnormal hemoglobin, was described in one Japanese fami...

Ngày tải lên: 02/11/2012, 10:09

... The Y 4a and Y 3a ions at m/z 996 and 8 34 obtained by ESI-IT- MS/MS analysis are in agreement with a linear arrangement of hexoses whereas the Y 1a and B 4a ions at m/z 44 6 and 713 Table 3. Fragment ... using similar conditions. Pyridylamination of oligosaccharides Chemically and enzymatically released oligosaccharides were pyridylaminated according to Kuraya et al.[37]...

Ngày tải lên: 31/03/2014, 08:20

... on academic didacticsin medicine, with the faculty members at each medicalschool focusing on a separate area: “examination andstandards in examination,”“e-learning in medicine,”“evaluation of ... medicine,”“evaluation of teaching,”“practical year,” and “prepara-tion for final examination.” The practical year is aFrank and Frank Child and Adolescent Psychiatry and Mental Health 2010,...

Ngày tải lên: 25/10/2012, 10:06

... gradual increase in the size of the uterus with advancing pregnancy can cause a delay in the diagnosis and appropriate treatment. The first laparoscopic surgery during pregnancy was ... uterine wall, the fetal heart rate was 171 beats/min, and uterine contractions were absent. La-boratory analysis showed a hemoglobin level of 10.3 Ivyspring International Publisher Int. ... aborti...

Ngày tải lên: 25/10/2012, 10:56

... the amount of CYP 3A5 protein accurately as it can be affected by other factors, genetic (expression of m-RNA, stability of CYP 3A5 protein, dual metabolic pathway via CYP 3A4 and CYP 3A5 , linkage ... patients. Thus, GLM repeated measures approach seems to be a more accurate me-thodology for the analysis of such data but it is more demanding in the quantity of available data....

Ngày tải lên: 26/10/2012, 09:32

... cerebral cortex. Demyelinating plaques may disrupt reflex pathways in the insular, cingulated and ventromedial prefrontal cortices, central nucleus of the amygdala, paraventricular hypothalamus and ... defined as symptoms of orthostatic intolerance(>6months) accompanied by a heart rate increase of at least 30 beats/min (or a rate that exceeds 120 beats/min) that occurs in the...

Ngày tải lên: 26/10/2012, 09:39

... spontaneous pH-dependent hydrolysis and an en-zymatic hydrolysis by plasma/serum and erythrocyte esterases (6). The circulating aspirin esterase activities are mainly due to butyrylcholinesterase ... pseudocholinesterase) and, in part, to albumin (6). Because of higher aspirin esterase activity lead-ing to faster aspirin hydrolysis, the same dose of as-pirin in people who metabolize a...

Ngày tải lên: 26/10/2012, 09:39

... brain tissue revealed systematically less BRCA1, and surprisingly in many cases with ap-parent phosphorylated tau-positive neurofibrillary tangles, BRCA1 was absent, yet BRCA1 was present in all ... presence of BRCA1, a known regulator of cell cycle, and found intense and specific localization of BRCA1 to neurofibrillary tangles, a hallmark lesion of the disease. Analysis of...

Ngày tải lên: 26/10/2012, 10:04