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Báo cáo y học: "Clinical Strategy for the Management of Solid Pseudopapillary Tumor of the Pancreas: Aggressive or Less"

Báo cáo y học:

Báo cáo y học: "Clinical Strategy for the Management of Solid Pseudopapillary Tumor of the Pancreas: Aggressive or Less"

... located in the portion of body or tail of the pancreas. For tumors of SPT located in the neck and body of the pancreas, resection of the mid-portion of the pancreas and the mass with preserving the ... Strategy for the Management of Solid Pseudopapillary Tumor of the Pancreas: Aggressive or Less? Hong Chang1, Yi Gong2, Jian Xu1, Zhongxue Su1, Chengkun Qin1, Zhenhai Zhang1 1. Department of ... (SPN), the experience with the management of disseminated disease is very limited in the literature6, therefore, attention to the therapy strategy of this neoplasm in the future may...
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Báo cáo Y học: Guanosine diphosphate-4-keto-6-deoxy-D-mannose reductase in the pathway for the synthesis of GDP-6-deoxy-D-talose in Actinobacillus actinomycetemcomitans potx

Báo cáo Y học: Guanosine diphosphate-4-keto-6-deoxy-D-mannose reductase in the pathway for the synthesis of GDP-6-deoxy-D-talose in Actinobacillus actinomycetemcomitans potx

... respectively) to the proteins enco-ded by ORFs in the clusters responsible for synthesizing the SPAs in other serotypes of A. actinomycetemcomitans. The biosynthetic pathway for GDP-6-deoxy-D-talose,Fig. ... and the stereoselectivity of the reduction deter-mines the direction of synthesis of these two 6-deoxyhex-oses. However, neither the gene encoding the biosynthesis of GDP-6-deoxy-D-talose nor ... of the genes essential for SPAbiosynthesis in A. actinomycetemcomitans SUNYaB 75are lower than the average GC content (47.8%) of the genes flanking them. The GC contents of ORF2, ORF7,and ORF9...
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Báo cáo Y học: Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant doc

Báo cáo Y học: Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant doc

... namely that they contain ahydrogen-bond donor in wing2. This property is of generalimportance for the efficacy of the inhibitor. Substitution of the hydrogen-donating amide group for a methylene ... plane of the thioureamoiety and the Ca of G190.Hence, the undefined orientation of the N103 amide Od1and Nd2 atoms may r eflect the repulsive forces exerted on the inhibitors.Other factors of ... to theirinhibitory efficacy. However, these factors may not solelyaccount for t he total reduction in inhibitory efficacy causedby the K103N mutation. An additional factor was presentedby Hsiou...
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Báo cáo khoa học: A strategy for the generation of specific human antibodies by directed evolution and phage display An example of a single-chain antibody fragment that neutralizes a major component of scorpion venom docx

Báo cáo khoa học: A strategy for the generation of specific human antibodies by directed evolution and phage display An example of a single-chain antibody fragment that neutralizes a major component of scorpion venom docx

... specific for Cn2 toxin(Fig. 2), they were not able to neutralize it. Analysis of the affinity constants showed values in the range 10)7m(Table 1), which are typical affinity values for the primary ... j chains andeach HuVkFOR with a mixture of HuJkBACK for kchains. A GeneAmp PCR thermocycler (Perkin-Elmer9600, Norwalk, CT, USA) was used for PCR. The condi-tions for the amplifications were: ... VH3-VK3 were the closest families for VHand VLdomains, respectively. In the case of C1, VH3-Vk1 were the families with highest scores. The specifici-ty of these two scFvs was determined by phage-ELISA(Fig....
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Báo cáo Y học: A model for recognition of polychlorinated dibenzo-p-dioxins by the aryl hydrocarbon receptor docx

Báo cáo Y học: A model for recognition of polychlorinated dibenzo-p-dioxins by the aryl hydrocarbon receptor docx

... [16]. For both FixL and PYP, structures are known for the inactive and active signaling states. In the case of PYP,conformational changes occur in the neighborhood of the p-hydroxycinnamoyl cromophore ... model of the ligand binding domain(LBD) of the mouse aryl hydrocarbon receptor (mAhR). The model allowed us to putatively i dentify the residuesresponsible for the recognition of polychlorinated ... as in our case, t hecorrectness of the alignment plays a crucial role both in the selection of the correct template and in the expected ®nalquality of the model. Other information, such as predictedand...
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 Báo cáo y học:

Báo cáo y học: "Clinical review: Treatment of new-onset atrial fibrillation in medical intensive care patients – a clinical framework"

... the start of AF [44].Conclusion on morbidityIn all patient categories, AF is associated with increasedmorbidity. This is reflected by the number of reportedsymptoms and by the days spent in the ... that the cause of AFis multifactorial. There are more or less permanent changes inmorphology and more or less temporary changes inhaemodynamic balance, electrolyte balance, neural balanceand hormonal ... contraction, by irregularity of ventricularcontraction [43], by inadequate filling time for the leftventricle due to tachycardia, and by tachycardiomyopathy[8,44]. Tachycardiomyopathy can occur...
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Báo cáo y học:

Báo cáo y học: "Clinical review: Medication errors in critical care"

... Spontaneous reporting of medicationerrors may under-report events [11,22]. Review of themedical records is considered by many experts the bench-mark for estimating the extent of errors and adverse ... medicationerrors?Medication errors are an important cause of patient morbidityand mortality [9]. Although only 10% of medication errorsresult in an ADE, these errors have profound implications forpatients, ... areskill-based behavior errors, when a routine behavior ismisdirected or omitted. The person has the right idea butperforms the wrong execution. For example, forgetting torestart an infusion of heparin...
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Báo cáo y học:

Báo cáo y học: "Parvovirus B19 Genotype Specific Amino Acid Substitution in NS1 Reduces the Protein’s Cytotoxicity in Culture"

... apoptosis as the underlying mechanism for the cytotoxicity observed in the setting of transient B19 NS1 expression (34). We therefore examined whether the reduced cell loss ob-served in the PathI ... room temperature in the dark and immediately ana-lyzed by flow cytometry. The percentage of cells ex-pressing the EGFP marker, as well as the distribution of signal intensity for each construct ... per sample for each experiment. For trans-duction efficiency analysis, 5 x 105 HepG2 cells were resuspended in 500 µL of ice-cold PBS and imme-diately analyzed by flow cytometry. For AnnexinV...
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Báo cáo y học:

Báo cáo y học: "Enhanced surveillance for childhood hepatitis B virus infection in Canada, 1999-2003"

... screening for HBsAg in non-Canadian-born children may provide the means for detecting most HBsAg carriers with heretofore undiagnosed HB. Screening in these children for HBV is important for identifying ... jurisdiction, either automatically reported or were contacted regularly for newly identified HB cases, laboratory test results, and other related information. A standardized data collection form was ... in the early years of life [8]. There is a continuing need to examine the effectiveness of the Canadian HBV vaccination strategy. Regarding the possible need for new HBV prevention strategy in...
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Báo cáo y học:

Báo cáo y học: "Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects"

... responsible for the thermolability of MTHFR. Actually, the frequency of the mutated allele was quite high, depending on the ethnic group analyzed [18-21]. Some authors suggested that the homozygosity for ... persons, and the results were concordant for all masked cases. Statistical analysis: The distributions of plasma tHcy concentrations were positively skewed; therefore, they were transformed logarithmically ... explained by the presence of other factors that raise plasma tHcy with age, especially the increased deterioration in other organ functions. The later was reflected in the present study by the higher...
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