Báo cáo khoa học: "Effect of intern’s consecutive work hours on safety, medical education and professionalism"

Ngày tải lên: 25/10/2012, 10:45

... Optimization of a-acylaminoketone ecdysone agonists for control of gene expression. Bioorg Med Chem Lett 13, 1883–1886. 18 Tice CM, Michelotti EL & Hormann RE (2004) Ketone ligands for ecdysterone ... of 20 lL reaction volume containing 1 lL of cDNA, 1 lL of each of forward and reverse sequence specific prim- ers (from 10 lm primer stock), 10 lL of supermix (Bio-Rad Laborat...

Ngày tải lên: 30/03/2014, 03:20

... characterization and identifica- tion of a novel family of enzymes. J Biol Chem 279, 23615–23621. 14 Bellon G, Berg R, Chastang F, Malgras A & Borel JP (1984) Separation and evaluation of the cis and ... with coil conversion of colla- gen-like polytripeptides in aqueous and nonaqueous solvents. Comparison of the thermodynamic parameters and the binding of water to (l-...

Ngày tải lên: 30/03/2014, 02:20

Ngày tải lên: 25/10/2012, 10:41

... impact of silencing TRBP and Dicer on the function of the fully paired and mismatched sequences, we wished to examine Fig. 1. Effect of guide strand 5¢ end mismatch on silencing efficacy of siRNAs. ... mRNA or a non-targeting (NT) siRNA at a final concentration of 10 n M. Fluorescence was measured 24 h after transfection. The mean and standard deviation are shown for each co...

Ngày tải lên: 18/02/2014, 06:20

... absence of ligand, the WPD loop of PTP1B and RPTPa adopts an open (inactive) conformation, and upon ligand bind- ing, it adopts a closed (active) conformation (Fig. 3A). In oxidized PTP1B [12,13] and ... 136.4) and the w torsion angle of Gly255 (18.9 to )157.9) upon oxida- tion. This large rotation of the peptide bond between Ala254 and Gly255 results in a 4.12 A ˚ movement...

Ngày tải lên: 18/02/2014, 18:20

... compilation ª 2006 FEBS occur outside the amphipathic groove, which probably contributes to a stable three-dimensional configuration with an opportunity for conformational modulation of the target ... function is dependent on interactions with 14-3-3 and factor activating ExoS (FAS) protein cofactors [24–26]. As this interaction is necessary for the ADP-ribosyla- tion activity of ExoS,...

Ngày tải lên: 19/02/2014, 08:20

... role of this region in the transcription of the Ig-b gene. Deletion of region III decreased the expres- sion of Ig-b mRNA to 40% of the expression in prede- letion cells (Fig. 4A). Region III ... hybridization. Position of the probes, the size and position of restriction fragments hybridizable with the probe, and exon ⁄ introns are shown as in Fig. 2A. Positions of the DT4...

Ngày tải lên: 19/02/2014, 16:20

... several cytoplasmic ligands. It is activa- ted by millimolar concentrations of ATP and micromo- lar Ca 2+ , and inhibited by higher concentrations (> 100 lm)ofCa 2+ and by millimolar Mg 2+ . ... pore [10]. Results about the effect of the luminal (trans) calcium on the activity of the RyR1 are controversial depending on experimental conditions. Inhibition of the channel wa...

Ngày tải lên: 19/02/2014, 16:20

... determined under pseudo first order conditions using 0.02–0.15 m M concentration range, in which the activity was a linear function of the substrate concentration. The standard error for kinetic values ... in bold. b The type of mutation: natural polymorphism (P), mutation appearing only in drug resistance (R, see Fig. 1). If two mutations occurred and one of them was occurring only in...

Ngày tải lên: 21/02/2014, 03:20