... METHODSMaterialsAll amino-acid residues, preloaded 4-hydroxymethyl-phenoxymethyl-copolystyrene-1%-divinylbenzene resin[Fmoc-Lys(Boc)-HMP], O-benzotriazol-1-yl-N,N,N0,N0 - tetramethyluronium ... conclusion, we have shown that head-to-tail cyclization of the ODN agonist OP and the weak antagonist [D-Leu5]OPenhances their biological activity on rat astrocytes leading to a super-agonist and to ... TTN,triakontatetraneuropeptide; HMP, 4-hydroxymethyl-phenoxymethyl-copolystyrene-1%-divinylbenzene resin; HBTU, O-benzotriazol-1-yl-N,N,N0,N0-tetramethyluronium hexafluorophosphate; HOBt,1-hydroxybenzotriazole;...