... central obesity and the metabolic syndrome [2,18]. The risk of developing all other components of the metabolic syndrome increases with obesity, supporting the hypothesis that obesity is the central ... for the catabolism of atherogenic lipoproteins [32,35–37]. In this study, we sought to determine the role of ApoE in the development of diet-induced obesity, glu-cose intolerance and insulin ... 120 min postinjection through the tail vein, and glucose levels were measured.Determination of plasma insulin and leptin levelsInsulin and leptin levels in the plasma of mice were deter-mined...