... B-chain and A-chainwere linked by an eight-residue linker sequence. Forinsulin and insulin-like growth factor-1, the C-terminus of the B-chain and N-terminus of the A-chain can belinked by an extremely ... protein- coupled receptor, RXFP2. Study of the peptide has relied upon chemicalsynthesis of the separate A- and B-chains and subsequent chain recombi-nation. To establish an alternative approach to ... hormonemember of the insulin superfamily that includes nineother members in humans, including insulin, insulin-like growth factor-1 and -2, relaxin-1, -2 and -3, and INSL4, -5 and -6. INSL3...