MIS in pediatric solid tumor

... and to define the upper limit of pore size within the BTB of the respective solid tumors Using this approach, we found that the physiologic upper limit of pore size in the BTB of brain RG-2 gliomas ... over-estimation of the actual physiologic upper limit of pore size within the BTB of peripheral solid tumors Therefore, if the ac...

Ngày tải lên: 18/06/2014, 15:20

... observed in of patients with RCC in this study confirmed the efficacy of everolimus in Chinese patients with RCC, consistent with experience from the larger phase III study in RCC [11] At the time of ... al.: Two-dose-level confirmatory study of the pharmacokinetics and tolerability of everolimus in Chinese patients with advance...

Ngày tải lên: 10/08/2014, 21:23

... DOX Interestingly, binding to proteins affects DOX delivery differently in the plasma and extracellular tumor space While increasing the fraction of bound DOX in the plasma inhibits delivery to ... [34,35], and larger tumors have greater IFP everywhere [21] Tumor cord geometry parameters Vessel and cord radii Tumors can vary greatly in the level of perfusion and...

Ngày tải lên: 13/08/2014, 16:20

... redistribution of metal speciation during composting by humification of the organic matter Chromium speciation in municipal solid 0 day q 20th waste 21 of cornpasting Cr (w/kg) day of composting Control ... 1) In contrast to the decrease of soluble organic matter during sludge composting, it gradually increased during the composting of MSW although the increme...

Ngày tải lên: 23/09/2012, 14:48

... anti -influenza virus antibodies Serum from subjects with past history of influenza virus vaccination or no infection was incubated with nitrocellulose strips containing influenza virus vaccine ... and elevated in adults and children vaccinated with Influenza virus Children with no history of either Influenza virus infection or vaccination had s...

Ngày tải lên: 25/10/2012, 11:10

... metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury Hum Pathol 2006; 37:422-430 Hammer J, Numa A, Newth CJ Acute respiratory distress syndrome caused by respiratory syncytial virus ... M, Cleroux P, Tremblay P, et al Increased proteolytic activity and matrix metalloproteinase expression in lungs during infection by porcine reproductive and respirato...

Ngày tải lên: 03/11/2012, 11:48

... Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer Cancer Sci 98, ... Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine k...

Ngày tải lên: 16/02/2014, 09:20

... compete with ATP for binding to the tyrosine kinase pocket of the receptor, thereby inhibiting receptor tyrosine kinase activity and EGFR signaling pathways (Fig 1) Early clinical studies showed ... (2006) Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors Genes Dev...

Ngày tải lên: 16/02/2014, 09:20

... (2006) Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors Genes Dev 20, 1496–1510 ... Suppression of epidermal growth factor receptor, mitogen-activated protein kinase, and Pak1 pathways and invasiveness of human cutaneous squamous cancer cells by the...

Ngày tải lên: 16/02/2014, 09:20

... Unlike infliximab, adalimumab is prescribed as a subcutaneous injection every weeks as a maintenance therapy. 28,29 Infliximab use in children Studies evaluating the safety and efficacy of infliximab ... and in inducing and maintaining remission in patients with active CD ACCENT I was a multicenter randomized double-blind international trial studying retreatment and remissio...

Ngày tải lên: 22/03/2014, 10:20

... obtained from human invasive ductal breast carcinoma Immunohistochemical analysis showed specific staining for breast tumors: positive staining was detected mostly in primary breast carcinomas and ... polymeric nanoparticles, potent protease inhibitor cystatin and a specific anti-cytokeratin monoclonal IgG, which can be internalized into cells, contributes specific targeting to inv...

Ngày tải lên: 23/03/2014, 07:20

... -Kei Lutalo PhD, NRCP Email:klutalo@gmail.com Clinical Findings in Pediatric Respiratory Disorders Submitted in 2005 ... compliance causes an increased work of breathing and the following clinical findings Patient identification Primarily occurs in infants of less than 34 weeks gestational age Chief complaint Respiratory ... occur in more severe cases The cli...

Ngày tải lên: 29/03/2014, 11:21

... Alterations in the activity and isozymic profile of human phosphofructokinase during malignant transformation in vivo and in vitro: transformation -and progression-linked discriminants of malignancy Cancer ... N-terminal segment [54] Hexokinase- I is predominantly located in brain, kidney, retina and breast, whereas hexokinase- II is abundant in skeletal muscle and a...

Ngày tải lên: 30/03/2014, 11:20

... protein-protein interactions THD2 consists of one or more PEST signals rich in proline, serine and threonine residues, while THD3 harbors a novel PHD zinc finger- and/ or bromodomain-interacting ... carcinoma TRIP-Br2 is overexpressed in multiple human solid tumors and associated with poor prognosis in hepatocellular carcinoma (HCC) (A) Multiple human tumor tissue arr...

Ngày tải lên: 18/06/2014, 15:20

... feature prominently in both overt carcinomas [37,50] and in the present series (the gains were found in of cases with bilateral borderline tumors and in of informative unilateral tumors showing imbalances) ... calculated in the present series was 18.72 It is interesting to note that for the bilateral borderline ovarian tumors the ANCA index was 24.5 whereas for the unilateral...

Ngày tải lên: 18/06/2014, 16:20