Báo cáo khoa học Injectable nanoparticles for drug delivery

... outstanding anti-infective properties [18] Both amphotericin B and miconazole self-assemble and solubilize at hydrophobic sites of DODAB or DHP bilayer fragments in water solution exhibiting in ... fungus viability For final coverage with polylysines (PL) of increasing molecular weight at mg/mL PL, there was an increase in the final zeta-potential modulus and a larger loss...

Ngày tải lên: 11/08/2014, 00:22

... helicase from Plasmodium falciparum is homologous to p68 Mol Biochem Parasitol 140, 55–60 Helicases as an antimalarial drug target 21 Pradhan A, Chauhan VS & Tuteja R (200 5) Plasmodium falciparum ... AD, Rao BG & Jeang KT (200 5) Viral and cellular RNA helicases as antiviral targets Nat Rev Drug Discov 4, 845–853 27 Frick DN (200 3) Helicases as antiviral drug...

Ngày tải lên: 18/02/2014, 16:20

... chain and had closer contacts with the CB atom of Ala82 in PRV8 2A than observed for Val in the ˚ PR The CE atom of P3¢ Arg moved  1.2 A and formed closer interactions with the CB atom of Ala82 All ... and inactive mutant V8 2A D25N with patients [8–10] We have reported crystal structures of PR, single mutants in complex with substrate analogs CA-p2...

Ngày tải lên: 30/03/2014, 20:20

... Biodegradable Nanoparticles are Excellent Vehicle for Site Directed in-vivo Delivery of Drugs and Vaccines Anil Mahapatro1 and Dinesh K Singh2* Bioengineering Program & Department of Industrial ... [22] BIODEGRADABLE NANOPARTICLES Biodegradable nanoparticles have been used for site- specific delivery of drugs, vaccines and various other biomolec...

Ngày tải lên: 11/08/2014, 08:20

... 10.1186/1477-7517-7-16 Cite this article as: Shaw et al., Increased risk for hepatitis C associated with solvent use among Canadian Aboriginal injection drug users Harm Reduction Journal 2010, 7:16 Page of ... future face of coinfection: prevalence and incidence of HIV and Hepatitis C virus coinfection among young injection drug users J Acquir Immune Defi...

Ngày tải lên: 11/08/2014, 18:20

... coordination and statistical analysis MB, LW and AF participated in study planning, coordination and data collection GH participated in study planning and supervision of BJ and MB All authors read ... consent was obtained, participants completed demographic information, baseline measures of physical and psychological health and their first 15minute expressive writing task The followin...

Ngày tải lên: 11/08/2014, 18:20

... on overdose prevention education and naloxone administration Overdose prevention training included teaching and discussing (a) the causes of opiate overdose (i.e loss of tolerance, mixing drugs, ... drugs, and minimize using alone), and (c) signs of an opiate overdose The naloxone training included information on naloxone, education about appropriate responses to...

Ngày tải lên: 11/08/2014, 18:20

... end -of- life issues to patients and their families [11] It is not uncommon for physicians to ask loaded questions in their quest for end -of- life decisions For example, ‘This is your grandmother’s ... futile Under the current rules, the only test of futility is that embodied by the question, ‘Will this treatment result in sustained life?’ If the answer is ‘yes’, then virtu...

Ngày tải lên: 25/10/2012, 10:45

... for interaction proteomics Anal Chem 74, 4725–4733 Kagebayashi C, Yamaguchi I, Akinaga A, Kitano H, Yokoyama K, Satomura M, Kurosawa T, Watanabe M, Kawabata T, Chang W et al (2009) Automated ... Differential glycan profiling between cancer and normal cells enables identification of aberrant glycosylation in cancer [indicated as a red triangle in (B) and (C)] as an alteration in...

Ngày tải lên: 16/02/2014, 08:20

... understanding of how interactions could take place in different regions of the molecule As part of a long-term function-oriented structural effort aimed at understanding the molecular bases of polyQ ... molecular bases of polyQ disease proteins, we report here a study of the structural determinants for the interactions of Anp32a with other partners As a prerequisite...

Ngày tải lên: 18/02/2014, 17:20

... sugar-binding proteins should be defined in terms not of the affinities for sugars but of whether the protein adopts the open form or the closed form TvuCMBP–c-CD complex is seen as the closed form (Fig ... sugar-binding protein family was found to be located upstream of the TVA II gene, and the affinities of this protein for c-CD were higher than that for maltose [7] The results sug...

Ngày tải lên: 19/02/2014, 00:20

... protein, additional information about post-translational modifications, like 2895 Signal peptidase I activity in M pneumoniae Fig SIGNAL P predicted and experimentally verified cleavage site for P40 ... N-terminal part of the peptide, it is evident that the N-terminal amino acid is asparagine (position 26), but increased in mass by 136 Da Because this modification is only p...

Ngày tải lên: 19/02/2014, 18:20

... restriction The Framework The framework within which we are working is presented in schematic form in Fig This framework has evolved after careful consideration of a number of factors Foremost among ... notation adopted for syntactic categories, however, was not elaborate enough to express the relations of natural languages Later, the author 9, 10 proposed a syntactic method for...

Ngày tải lên: 19/02/2014, 19:20

... F-score on gold and auto POS tags for the C&C n-best parser # denotes the inclusion of dependency hashing Training data no hashing hashing Test data no hashing hashing 86.83 86.35 87.21 87.15 Table ... and evaluation CCGbank (Hockenmaier, 2003) is a transformation of the Penn Treebank (PTB) data into CCG derivations, and it is the standard corpus for English CCG parsing Other...

Ngày tải lên: 19/02/2014, 19:20