... Hyaluronan modulates accumulation of hypoxia -inducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model Arthritis ... mirrors much of the pathology of RA, including hyperplasia of the synovial tissues, inflammatory infiltration of the joints, and destruction of bone and cartilage in the synovial joint [23] The present ... infiltration in the synovium and accumulation of HIF-1a, iNOS, and MMP3 were suppressed after intra-articular administration of HA at the early phase of adjuvant-induced inflammation The extent of...