... 4641 Therapeutic aspects of VEGF in brain diseases M Shibuya which to rapidly and efficiently suppress vascular leaks during the clinical course of brain diseases or during the treatment of brain ... Shibuya Therapeutic aspects of VEGF in brain diseases [3] The BBB mainly consists of a strong interaction between vascular endothelial cells and astrocytes,...
Ngày tải lên: 18/02/2014, 11:20
... on the 5¢-UTR The single-strand RNA and DNA binding, cold shock domain (CSD) (also known as Y-box) proteins, play diverse roles in both transcriptional and post-transcriptional regulation of growth ... that CSD proteins form a cytoplasmic complex on VEGF mRNA that also contains the multifunctional singlestrand RNA/DNA binding protein, PTB [43–46,52–57], an...
Ngày tải lên: 19/02/2014, 12:20
Tài liệu Báo cáo khoa học: Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms ppt
... investigated the effect of PF -4 on another angiogenic factor of prime importance, VEGF, and compared the mechanisms by which PF -4 inhibits the DNA synthesis induced by VEGF165 and VEGF121 The DNA synthesis ... [26] and (b) PF -4 inhibits the DNA synthesis induced by VEGF165 and VEGF121 PF -4 does not affect VEGF121 -induced KDR phosphorylation We analy...
Ngày tải lên: 19/02/2014, 16:20
Báo cáo khoa học: The C-terminus of viral vascular endothelial growth factor-E partially blocks binding to VEGF receptor-1 docx
... VEGFR specificity of the viral VEGFs It has been hypothesized that the inability of viral VEGF to bind VEGFR-1 may be due to the absence of a functional groove on the receptorbinding face of the ... Deletion of the C-terminus of ORFVNZ 2VEGF increases its affinity for VEGFR-1 and VEGFR-2 To investigate the role of the ORFVNZ 2VEGF C-terminus in re...
Ngày tải lên: 23/03/2014, 07:20
Báo cáo sinh học: " Vascular endothelial growth factor regulates melanoma cell adhesion and growth in the bone marrow" ppt
... BMSCs and cancer cells, which give to the latter a selective advantage for growing in bone [12] and for inducing bone destruction [33], the adhesion and proliferation of melanoma cells in response ... Valcárcel et al.: Vascular endothelial growth factor regulates melanoma cell adhesion and growth in the bone marrow microenvironment via tumor cyc...
Ngày tải lên: 18/06/2014, 22:20
báo cáo hóa học: " Vascular endothelial growth factor-A and chemokine ligand (CCL2) genes are upregulated in peripheral blood mononuclear cells in Indian amyotrophic lateral sclerosis patients" pot
... b-actin ALS, amyotrophic lateral sclerosis; VEGF-A, vascular endothelial growth factor-A; CCL2, chemokine ligand- 2; PBMCs, peripheral blood mononuclear cells levels did not vary between definite, ... represented by x-axis in part “A” ALS, amyotrophic lateral sclerosis; VEGF-A, vascular endothelial growth factor-A; CCL2, chemokine ligand- 2; PBMCs, per...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học: " Neuroprotective response after photodynamic therapy: Role of vascular endothelial growth factor" pot
... Neuroprotective response after photodynamic therapy: Role of vascular endothelial growth factor Misa Suzuki1,2,3, Yoko Ozawa1,2*, Shunsuke ... induction of VEGF after PDT [22] This isolated study prompted concern that VEGF elevation after PDT could activate growth of residual neovascular tissue Therefore, these two types of vascular ... understanding of its...
Ngày tải lên: 19/06/2014, 22:20
báo cáo hóa học:" Vascular endothelial growth factor regulates osteoblast survival – evidence for an autocrine feedback mechanism" pptx
... growth factors (IGF-I and -II), transforming growth factor beta (TGFβ), platelet derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) Cytokines that enhance osteoclast function and ... Materials and Methods mAB VEGF: neutralising monoclonal antibody to vascular endothelial growth factor isotype 165 (0.3 ug/mL), VEGF: vascular endothelial growth f...
Ngày tải lên: 20/06/2014, 01:20
Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
... including hypoxic conditions and stimulation by transforming growth factor, CD40 ligand, interleukin 1, or interleukin [10] Oxidative stress also promotes angiogenesis [13] The link between oxidative ... diffusible proteins from mature, monomeric VEGF), but not human placenta-derived growth factor, platelet-derived growth factor, or transforming growth factor In...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers" doc
... angiostatic factors, another strategy for the treatment of ischemic symptoms in SSc is the inhibition of angiostatic factors rather than a further increase of VEGF Angiostatic factors are often cleaved ... stimulation [30] Hypoxia increases the synthesis of VEGF in a variety of cell types via an accumulation of the transcription factor hypoxia induci...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: "Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis" ppt
... ADAM15 in RA synovial tissues studied by in situ hybridization, immunohistochemistry and immunoblotting Cells expressing ADAM15 mRNA were examined by in situ hybridization Synovial lining cells, endothelial ... the recombinant human disintegrin domain of ADAM15 itself exhibits anti-angiogenic activity, probably by disturbing the interaction between ADAM15 and integ...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo y học: "Reactive oxygen species induce expression of vascular endothelial growth factor in chondrocytes and human articular cartilage explants" pps
... changes in biosynthetic activity [15], in addition to apoptosis [16] In addition, ROS can influence transcription factors in chondrocytes and induce the expression of catabolic cytokines [17] ... necessary to investigate the signal transduction pathways of PMA and SIN-1 in chondrocytes Conclusion By amplifying distinct ROS-dependent destructive pathways in cartila...
Ngày tải lên: 09/08/2014, 08:23
báo cáo khoa học: " Cyclooxygenase-2 up-regulates vascular endothelial growth factor via a protein kinase C pathway in non-small cell lung cancer" pdf
... Luo et al.: Cyclooxygenase-2 up-regulates vascular endothelial growth factor via a protein kinase C pathway in non-small cell lung cancer Journal of Experimental & Clinical Cancer Research 2011 ... Dohadwala M, Dubinett SM: Prostaglandin E2 activates mitogen-activated protein kinase/ Erk pathway signaling and cell proliferation in non-small cell l...
Ngày tải lên: 10/08/2014, 10:20