... heterogeneity of RPE cells [31,48] Effects of hypoxia on the expression of HO-1 in human RPE cell lines In contrast to interferon-c, hypoxia induced the expression levels of HO-1 mRNA in D407 cells and ... effects of interferon-c and hypoxia on HO-1 expression in human RPE cells, both of which have been shown to repress HO-1 expression in other types of human cells In addition, interferon-c induces ... ARPE-19 cells, indicating that Bach1 is not a sole determinant for HO-1 mRNA expression in ARPE-19 cells Likewise, hypoxia induced expression of HO-1 and Bach1 mRNAs in D407 cells, indicating that...