Physiology: The immune system

... that the adaptive immune system differentially modulates de novo cancer development in an organ-dependent and aetiology-dependent manner The paradoxical influence of the adaptive immune system during ... to be resolved with these powerful approaches is how therapeutically manipulating one arm of the immune system affects the anticancer or cancer- promoting p...

Ngày tải lên: 15/03/2014, 01:20

... mounting evidence that in ammatory cell in ltrates play a significant role in driving the pathogenesis of asthma and other allergic diseases by damaging tissue and releasing pro -in ammatory agents ... was only diminished by < 50% in the Y6 67F mutant, indicating that SHP-2 may be binding both to the tyrosine at position 667 and to other tyrosines in the cytoplas...

Ngày tải lên: 24/03/2014, 04:21

... well recognized for the regulation of immune responses The effect of parasites, for example, has been to dampen, rather than fully ablate, immune responsiveness, and the degree of immunosuppression ... deeper understanding of the intimate co-evolution of pathogens and the immune system 10 11 12 13 14 Acknowledgements The author’s research is supported by grants...

Ngày tải lên: 06/08/2014, 19:20

... promoting (though not in initiating) the differentiation of TH17 cells, and more importantly, in inducing them to secrete the cytokine interleukin (IL)-22 (a cytokine implicated in the defense of mucosal ... functional subsets, distinguished by the different cytokines they produce (indicated under each CD4 T cell type): the cytokines act on other immune cells, activating the...

Ngày tải lên: 06/08/2014, 19:21

... R The The use of crossreactive monoclonal antibodies to characterize the immune system of the water buffalo (Bubalus bubalis) development and analysis of species specific and cross reactive monoclonal ... antigen Activation antigen (WC10) CD25 CD25 CD25 The use of crossreactive monoclonal antibodies to characterize the immune system...

Ngày tải lên: 07/08/2014, 15:20

... site is not known — whether these cells exist only transiently then die, whether they persist in the body as TR cells, or whether they return to their previous role as nonregulatory resting T cells ... development of CD4+CD25+ TR cells may occur in the periphery in man Induction of CD4+CD25+ TR cells in the periphery The induction of TR cells that re...

Ngày tải lên: 09/08/2014, 01:24

... ‘unhygienic’ areas inhale and ingest a different kind, variety and amount of bacteria compared with children of farmers and anthroposophic families, who have access to natural soil and eat only ... environmental antigens Facultative and professional antigen-presenting cells (dendritic cells) may be the target of a microbial bystander effect, that may dictate the pa...

Ngày tải lên: 12/08/2014, 18:20

... incredibly high number of different inputs and, at the same Figure Degeneracy, pluripotentiality and bow tie The concept of bow tie integrates the concepts of degeneracy and pluripotentiality: figuratively, ... figuratively, a bow tie structure (many-few-many) (1c) appears from the overlapping of degeneracy (many -to- one) (1a) and pluripotentiality (one -to-...

Ngày tải lên: 13/08/2014, 16:20

... hydrogen bond extends from the 1-hydroxyl oxygen to the aminoacetal of ARG274 and the hydroxyl of SER237, and another pair from the ligand's O3 oxygen to SER278 and TYR143 Figure shows that the ... double hydrogen bond between the oxygen of its triol group, the imidazole of HIS397, and the imidazole of HIS305 The 3-hydroxyl-oxygen is hydrogen-bonded to TYR 143 and...

Ngày tải lên: 13/08/2014, 23:20

... the cancerous cells (b) If elimination is unsuccessful, the immune system and the cancer can reach an equilibrium in which immune cells keep the cancer in check but cannot remove it completely ... layer (diamond-shaped cells) into cancerous cells (with irregular shapes), attack by various different cell types of the immune system (indicated by round cells) may lead t...

Ngày tải lên: 14/08/2014, 14:21

... promoting B-cell development by restraining the expression of pro-myeloid factors (such as Gfi1), and acting directly to induce the recombinase (Rag) genes and thereby recombination at the immunoglobulin ... the immunoglobulin heavy-chain locus Interestingly, Ikaros was found to bind at pericentromeric satellite DNA and could therefore play a role in the silencing of genes e...

Ngày tải lên: 14/08/2014, 20:22

... to TAMs in other parts of the tumor [8,30] In summary, inflammation and the immune system play critical roles in both tumor suppression and tumor progression Understanding the complex interactions ... unique Therefore, the study of the cross-talk between cancer cells and the immune system must be analyzed in the context of the organ in which th...

Ngày tải lên: 10/09/2015, 15:50

... is the number of melanoma cells at the end of the experiment, N is the number of melanoma cells at the onset of the experiment, k is the fraction of proliferating cells, t is the duration of the ... is the fraction of proliferating cells in the tumor of control mice and k d is the fraction of proliferating cells in the tumor of PMN-MDSC-de...

Ngày tải lên: 10/09/2015, 15:50

... with the light microscope under high magnification to check for the absence of bacteria swimming among the cells in the medium Infection of T cells with live B pseudomallei in the absence of a ... replication of B pseudomallei in T cell lines The interaction of B pseudomallei with mouse and human T cells provides a means to study how the bacterium c...

Ngày tải lên: 08/11/2015, 16:31